ijms-logo

Journal Browser

Journal Browser

New Advances in Platelet Biology and Functions: 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 81

Special Issue Editor


E-Mail Website
Guest Editor

Special Issue Information

Dear Colleagues,

Platelets, best known as the primary mediators of hemostasis and thrombosis, are a critical component of blood vessel walls. As secretory cells, platelets can release multiple substances from storage granules, biomediators, and membrane vesicles, influencing both physiological and pathophysiological processes. Conversely, platelets can uptake plasma and cellular components, influencing platelet responsiveness. The analysis of platelet function through the development of powerful imaging techniques, as well as the identification of cells and new molecules that regulate their activation and aggregation within vessels, are instrumental in order to better understand the mechanisms through which platelets protect or damage organisms. These analyses provide useful information for studying the pathogenesis of many disease states.

This Special Issue of the International Journal of Molecular Sciences, titled “New Advances in Platelet Biology and Functions: 3rd Edition”, will focus on recent advances in platelet function research, such as platelet action or the release of substances or microparticles containing platelet miRNA, enzymes, proteins, and small molecules with roles in healthy conditions and as drivers of immunity, inflammation, angiogenesis, and tumor growth. Contributions on these and related topics are welcome, including original research and reviews. We particularly welcome submissions from postdocs, PhD students, and young researchers.

Dr. Isabella Russo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • platelet microparticles
  • thrombosis
  • inflammation
  • oxidative stress
  • antiplatelet drug
  • signal transduction
  • immunity
  • tumor growth

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issues

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 1099 KiB  
Article
Comparative Evaluation of Platelet-Rich Fibrin (PRF) and Concentrated Growth Factor (CGF) as Carriers for Antibiotics—In Vitro Study
by Wojciech Niemczyk, Małgorzata Kępa, Jacek Żurek, Ali Aboud, Dariusz Skaba and Rafał Wiench
Int. J. Mol. Sci. 2025, 26(9), 4303; https://doi.org/10.3390/ijms26094303 - 1 May 2025
Abstract
The rising prevalence of antibiotic resistance underscores the need for localized drug delivery systems that minimize systemic exposure. Autologous platelet concentrates (APCs), including concentrated platelet-rich fibrin (c-PRF) and liquid-phase concentrated growth factors (LPCGFs), have emerged as potential carriers for antimicrobial agents. This study [...] Read more.
The rising prevalence of antibiotic resistance underscores the need for localized drug delivery systems that minimize systemic exposure. Autologous platelet concentrates (APCs), including concentrated platelet-rich fibrin (c-PRF) and liquid-phase concentrated growth factors (LPCGFs), have emerged as potential carriers for antimicrobial agents. This study aimed to evaluate the efficacy of c-PRF and LPCGF as carriers for three antibiotic formulations—amoxicillin with clavulanic acid, clindamycin, and a combination of amoxicillin with metronidazole—against methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), and Enterococcus faecalis (low-level natural resistance). The disk diffusion method was employed to incorporate antibiotics into both APC types, which were then applied to disks placed on bacterial cultures. The size of the inhibition zones was measured at 20-, 40-, 60-, and 80-h intervals. Every 20 h, the disks were transferred to a new Petri dish. Statistical analysis included Welch’s t-test and two-way ANOVA. c-PRF demonstrated superior performance as a carrier for amoxicillin and clindamycin, showing the presence of inhibition zones for up to 60 h. In contrast, LPCGF exhibited greater efficacy when used with the amoxicillin–metronidazole combination, particularly at higher concentrations. Both APCs showed limited effectiveness against E. faecalis when combined with clindamycin. The study confirms the suitability of autologous platelet concentrates as localized antibiotic delivery systems. The choice between c-PRF and LPCGF should be guided by the drug’s physicochemical properties and clinical application. APCs offer a promising alternative for targeted antimicrobial therapy in dental and surgical settings. Full article
(This article belongs to the Special Issue New Advances in Platelet Biology and Functions: 3rd Edition)
Show Figures

Figure 1

Back to TopTop