Mitochondrial Dysfunction and Oxidative Stress in Human Diseases: Molecular Targets and Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 18
Special Issue Editor
Interests: mitochondrial dysfunction; oxidative stress; host–pathogen interactions; molecular antimicrobial resistance; immunometabolism; diabetes and MASLD; translational infectious diseases research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria are central to cellular energy production, metabolic regulation, redox balance, and programmed cell death. Mitochondrial dysfunction and oxidative stress are increasingly recognized as common denominators in a wide spectrum of human diseases, including cardiovascular disorders, neurodegeneration, metabolic syndrome, cancer, and critical illness syndromes such as sepsis and multi-organ failure. These processes are deeply interconnected with immune dysregulation, inflammatory signaling, and altered cellular homeostasis.
Recent advances in molecular biology, bioenergetics, and redox medicine have shed light on the pathophysiological relevance of mitochondrial dynamics, ROS-mediated signaling, and mitophagy. Moreover, emerging therapeutic strategies targeting mitochondrial pathways—such as mitochondria-specific antioxidants, metabolic modulators, and redox-active compounds—are gaining ground in translational research and early-phase clinical trials.
This Special Issue aims to gather original research articles, comprehensive reviews, and translational studies that explore the molecular underpinnings of mitochondrial dysfunction and oxidative stress across human diseases. Topics of interest include but are not limited to mitochondrial bioenergetics and metabolic reprogramming, redox signaling, mitophagy and apoptosis, immunometabolic interactions, and therapeutic interventions aimed at restoring mitochondrial function and redox balance.
Submissions combining basic science with biomolecular investigation in human samples are especially welcome. Please note that purely clinical studies without a molecular component fall outside the scope of this Special Issue.
We look forward to your valuable contributions to this multidisciplinary and evolving field.
Dr. Carlo Acierno
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- mitochondria
- oxidative stress
- redox signaling
- mitophagy
- immunometabolism
- metabolic reprogramming
- ROS
- bioenergetics
- molecular therapeutics
- inflammation
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