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MicroRNA, Insulin Resistance, and Metabolic Disorders, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 1859

Special Issue Editor


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Guest Editor
1. Department of Biochemistry, Dongguk University School of Medicine, Gyeongju 38066, Republic of Korea
2. Channelopathy Research Center (CRC), Dongguk University School of Medicine, Ilsan 10326, Republic of Korea
Interests: mechanotransduction; cytoskeleton remodeling; proliferation; differentiation; myogenesis; sarcopenia; insulin resistance; diabetes; metabolism; glucose metabolism; lipid metabolism; metabolic diseases; energy metabolism
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Special Issue Information

Dear Colleagues, 

Insulin resistance, characterized as inadequate insulin signal transduction within cells, is a major global health issue linked to various diseases, including type 2 diabetes, dyslipidemia, hypertension, and atherosclerosis. Over the last few decades, microRNAs (miRNAs) are becoming a hot topic in molecular and cellular biology as "key modulators" of physiological and pathophysiological processes. They can orchestrate cell-to-cell communication and mediate cellular processes in numerous ways by controlling gene expression at the transcriptional, post-transcriptional, and translational levels. Despite growing evidence that miRNAs play a significant prognostic and therapeutic role in insulin resistance and metabolic diseases, the precise mechanisms by which miRNAs lead to insulin resistance and metabolic disorders are unclear.

This Special Issue will discover the novel function and mechanism of miRNAs in the pathogenesis of insulin resistance and metabolic disorders in various tissues and organs. Additionally, this issue will discuss recent advances in the development and potential application of miRNAs as novel biomarkers and therapeutic targets for metabolic diseases. We encourage contributions of original research and review articles on all aspects of miRNAs associated with insulin resistance and metabolic disorders.

More published papers could be found in the closed Special Issue: MicroRNA, Insulin Resistance, and Metabolic Disorders.

Prof. Dr. Wan Lee
Guest Editor

Manuscript Submission Information

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Keywords

  • microRNA
  • insulin resistance
  • metabolic diseases
  • insulin signaling
  • diabetes
  • obesity

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Published Papers (1 paper)

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Research

20 pages, 4255 KiB  
Article
Characterizing Circulating microRNA Signatures of Type 2 Diabetes Subtypes
by Fatima Sulaiman, Costerwell Khyriem, Stafny Dsouza, Fatima Abdul, Omer Alkhnbashi, Hanan Faraji, Muhammad Farooqi, Fatheya Al Awadi, Mohammed Hassanein, Fayha Ahmed, Mouza Alsharhan, Abdel Rahman Tawfik, Amar Hassan Khamis and Riad Bayoumi
Int. J. Mol. Sci. 2025, 26(2), 637; https://doi.org/10.3390/ijms26020637 - 14 Jan 2025
Viewed by 1227
Abstract
Type 2 diabetes (T2D) is a heterogeneous disease influenced by both genetic and environmental factors. Recent studies suggest that T2D subtypes may exhibit distinct gene expression profiles. In this study, we aimed to identify T2D cluster-specific miRNA expression signatures for the previously reported [...] Read more.
Type 2 diabetes (T2D) is a heterogeneous disease influenced by both genetic and environmental factors. Recent studies suggest that T2D subtypes may exhibit distinct gene expression profiles. In this study, we aimed to identify T2D cluster-specific miRNA expression signatures for the previously reported five clinical subtypes that characterize the underlying pathophysiology of long-standing T2D: severe insulin-resistant diabetes (SIRD), severe insulin-deficient diabetes (SIDD), mild age-related diabetes (MARD), mild obesity-related diabetes (MOD), and mild early-onset diabetes (MEOD). We analyzed the circulating microRNAs (miRNAs) in 45 subjects representing the five T2D clusters and 7 non-T2D healthy controls by single-end small RNA sequencing. Bioinformatic analyses identified a total of 430 known circulating miRNAs and 13 previously unreported novel miRNAs. Of these, 71 were upregulated and 37 were downregulated in either controls or individual clusters. Each T2D subtype was associated with a specific dysregulated miRNA profile, distinct from that of healthy controls. Specifically, 3 upregulated miRNAs were unique to SIRD, 1 to MARD, 9 to MOD, and 18 to MEOD. Among the downregulated miRNAs, 11 were specific to SIRD, 9 to SIDD, 2 to MARD, and 1 to MEOD. Our study confirms the heterogeneity of T2D, represented by distinguishable subtypes both clinically and epigenetically and highlights the potential of miRNAs as markers for distinguishing the pathophysiology of T2D subtypes. Full article
(This article belongs to the Special Issue MicroRNA, Insulin Resistance, and Metabolic Disorders, 2nd Edition)
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