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Special Issue "Environmental Chemical Mixture at Low Concentration and Children’s Health"
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601).
Deadline for manuscript submissions: closed (31 October 2017).
Prof. Dr. Hyunok Choi
Departments of Environmental Health Sciences, Epidemiology, and Biostatistics, University at Albany, School of Public Health, USA
Tel. +1-518-402-0401; Fax: +1-518-474-9899
A typical human exposure scenario to environmental chemicals could be characterized as a setting that lies in their occurrence as a complex mixture at a generally low exposure range. Under an environmentally-relevant mixture exposure scenario, the risk posed by constituent compounds is typically argued to be too low in concentration to pose a significant risk. However, to date, such an argument is based on the toxicity of a single compound. When toxicity data are available, human health risks from exposure to a mixture is presumed to follow either independent effects or a concentration addition model. However, a growing body of data suggests that the joint effect of human exposure to a mixture could be additive, synergistic, or antagonistic.
As of today, protective public health legislation within the US and Europe are largely based on single compound toxicity data. As human exposure to environmental chemicals is diverse, complex, and temporally variable, there is a growing recognition of the urgent need to protect the public through a deeper understanding the health risks of complex mixtures.
Additional sources of uncertainty regarding human health risks due to the exposure to mixtures stem from the lack of data for personal exposure/internal dose, temporal persistence of exposure, and a host’s underlying susceptibility (e.g., age, gender, genetic predisposition). Therefore, the goal of the present Special Issue is to provide a venue for presenting both experimental and human exposure, as well as health outcome data. In particular, quantification of exposure to complex mixtures, based on the use of biomarkers, is particularly encouraged. In addition, joint exposure and the associated effects of exposure concentrations and/or doses are sought.
In order to stimulate data generation, both clinically-meaningful outcomes, as well as intermediate (i.e., pre-clinical) health outcomes, are sought for this Special Issue.
This Special Issue is open to any subject area related to the use of environmental chemical mixture applications within public health. The listed keywords suggest just a few of the many possibilities.
Prof. Dr. Hyunok Choi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Quantitative structure–activity relationships
- Mixture toxicity
- Concentration addition
- Independent action
- Quantitative structure–activity relationship
- Mixture toxicity
- Biological Interactions
- Synergistic effect
- Antagonistic effects
- Multicomponent mixtures,
- Mode of action
- First order approximation for the joint effect