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Cost-of-Illness and Cost-Effectiveness in Disease Management

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Care Sciences".

Deadline for manuscript submissions: 15 May 2025 | Viewed by 2481

Special Issue Editor


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Guest Editor
Institute of Management, Scuola Superiore Sant’Anna, 56127 Pisa, Italy
Interests: diabetes; pancreatectomy; lupus; coronary artery disease; stress echocardiography Interests: biostatistics; health inequalities; economic impact of disease; rare diseases; cardiovascular diseases; cancer

Special Issue Information

Dear Colleagues,

A better understanding of the broad economic impact of diseases and their management is essential to properly define the strategies guiding rationale and sustainable clinical practice and prioritize interventions that relieve the economic burden of disease for patients, families and society.

In an era of continuous development of innovative treatments and technologies, there is an urgent need to produce evidence about the costs of illness and the cost effectiveness of alternative approaches to manage disease in order to evaluate the relative weight of different costs’ components not only from a third-payer perspective, but also from the perspective of society to reveal the burden of direct non-healthcare costs, and indirect and intangible costs.

This Special Issue welcomes applied studies to enhance knowledge about the cost-of-illness and cost-effectiveness in disease management using alternative approaches, as well studies focusing on the economic impact of health interventions or shocks (i.e., the COVID-19 pandemic) on disease-related costs over different patient groups and within different contexts. The submission of methodological papers proposing and discussing appropriate approaches to enable and reveal the proper evaluation and analysis of costs of illness and cost effectiveness is also encouraged.

Dr. Valentina Lorenzoni
Guest Editor

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Keywords

  • cost of illness
  • cost effectiveness
  • economic impact
  • disease burden
  • costs

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Published Papers (2 papers)

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16 pages, 651 KiB  
Article
The Economic Impact of Post-Traumatic Stress Disorder Among Patients with Systemic Autoimmune Diseases During the COVID-19 Pandemic
by Valentina Lorenzoni, Gianni Andreozzi, Ilaria Palla, Chiara Tani, Claudia Carmassi, Giovanni Fulvio, Francesca Trentin, Sara Fantasia, Lorenzo Conti, Liliana Dell’Osso, Marta Mosca and Giuseppe Turchetti
Int. J. Environ. Res. Public Health 2024, 21(11), 1476; https://doi.org/10.3390/ijerph21111476 - 6 Nov 2024
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Abstract
Background: The present work aimed to estimate the economic impact of PTSD following COVID-19 in a population of patients affected by systemic autoimmune disease (SAD) using a cost-of-illness approach and accounting for the perspective of society. Methods: Considering data collected from SAD patients [...] Read more.
Background: The present work aimed to estimate the economic impact of PTSD following COVID-19 in a population of patients affected by systemic autoimmune disease (SAD) using a cost-of-illness approach and accounting for the perspective of society. Methods: Considering data collected from SAD patients enrolled in a specialized outpatient clinic in the Tuscany region, Italy, generalized linear models and LASSO logistic regression were used to evaluate the impact of PTSD on costs and its relevance as a possible predictor of being a high-cost patient, respectively. Results: Considering 301 SAD patients, 161 (51.2%) of whom were diagnosed with PTSD, the overall costs were EUR 3670 [890; 40,529] per patient/year among patients with PTSD and EUR 2736.7 [283; 21,078] per patient/year among those without PTSD (p-value < 0.001), with differences mainly attributable to significantly greater direct non-healthcare and indirect costs. PTSD was estimated to increase overall costs (β = 0.296 (0.140), p-value = 0.035), direct non-healthcare (β = 1.193 (0.392), p-value = 0.002), and indirect costs (β = 3.741 (1.136), p-value = 0.001). PTSD diagnosis was also significantly associated with the likelihood of being a high-cost patient. Conclusions: Findings from the present study offer a novel perspective on the economic impact of COVID-19 and provide valuable data for policymakers to better understand the demand for healthcare services and associated costs. Full article
(This article belongs to the Special Issue Cost-of-Illness and Cost-Effectiveness in Disease Management)
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13 pages, 1424 KiB  
Review
Cost-Effectiveness Analysis of Photobiomodulation After Third Molar Extraction for Pain Control
by Thalita Molinos Campos, Mayra Costanti Vilela Campos, Raquel Agnelli Mesquita-Ferari, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Cinthya Cosme Gutierrez Duran, Alexandre Padilha, Aldo Brugnera Júnior, Samir Nammour, Ricardo Scarparo Navarro, Kristianne Porta Santos Fernandes and Lara Jansiski Motta
Int. J. Environ. Res. Public Health 2025, 22(2), 159; https://doi.org/10.3390/ijerph22020159 - 25 Jan 2025
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Abstract
This study aims to evaluate the cost-effectiveness of photobiomodulation applied after third molar extraction. Materials and Methods: To evaluate cost-effectiveness, 15 studies were selected for a systematic review and 8 studies for a meta-analysis to determine the effectiveness of photobiomodulation after surgery. In [...] Read more.
This study aims to evaluate the cost-effectiveness of photobiomodulation applied after third molar extraction. Materials and Methods: To evaluate cost-effectiveness, 15 studies were selected for a systematic review and 8 studies for a meta-analysis to determine the effectiveness of photobiomodulation after surgery. In the present study, as a measure of effectiveness, the pain scale (visual analog scale) was used. The laser value was extracted from the Unified Terminology of Supplementary Health (Brazilian Health System) according to the laser application protocol most common among the clinical trials selected for the meta-analysis. As for drugs, they were determined from those most used among the works included in the meta-analysis and within the protocols established by the Brazilian Ministry of Health. Results: The results of the overall analysis show a significant reduction in pain on the second day after surgery for the experimental group compared to the control (MD, −1.15; 95% CI, −1.73, −0.57). The control group has a lower cost and lower effectiveness, while laser treatment has a higher cost and higher effectiveness. Faced with this situation, the professional must clinically assess whether the cost of USD 34.62 for controlled pain intensity using the laser is worth the extra health benefit. Conclusions: Regarding the cost-effectiveness assessment, the control group has a lower cost and lower effectiveness, while laser treatment has a higher cost and higher effectiveness The decision of which treatment to choose must consider whether the cost of the therapeutic alternative outweighs the clinical gain caused by the treatment. Clinical Relevance: One of the most executed procedures in dentistry is the extraction of third molars. To reduce the negative post-surgical effects, anti-inflammatory drugs are prescribed, which can generate unwanted effects. Photobiomodulation is a technique to modulate inflammation, accelerate tissue repair, and reduce pain and discomfort in different clinical situations. Full article
(This article belongs to the Special Issue Cost-of-Illness and Cost-Effectiveness in Disease Management)
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