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Special Issue "Endocrine Disruptors Exposure on Human Health"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Health".

Deadline for manuscript submissions: 31 March 2019

Special Issue Editor

Guest Editor
Prof. Dr. Eui-Bae Jeung

Laboratory of Veterinary Biochemistry and Molecular Biology,College of Veterinary Medicine, Chungbuk National University, Republic of Korea
Website | E-Mail
Interests: reproductive toxicology; endocrine disruptors; animal anlternative tests; guidelines of toxicology; calcium metabolism; steroid receptors; stem cells in pharmacological and toxicological test

Special Issue Information

Dear Colleagues,

Endocrine disruptors (EDs) are environmental chemicals that interfere with the endocrine systems and adversely affect hormone balance or disrupt normal function of organs that hormones regulate or modulate, leading to detrimental effects in reproductive and developmental processes. Humans and animals come into contact with EDs through a variety of routes, including consumption of food and water, through the skin, by inhalation, and by transfer from mother to fetus across the placenta or mother to infant via lactation. Over the past few decades, the regulation of EDs has been debated among scientists, physicians, regulators, and the public. Key elements for the regulation of EDs are in process, and important discussions are ongoing, especially with regard to the establishment of criteria for the identification of endocrine disrupting substances. In this Special issue, recent progress in all aspects of EDs will be proposed for research, guiding the understanding of EDs. The research will give specific ways in which science can be employed for human health.

The aim of this Special Issue is to provide a forum to collect most recent progress in all aspects of EDs and their impacts on human health, to discuss possible ways forward, and to increase the level of knowledge and competence.

Prof. Dr. Eui-Bae Jeung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Endocrine disruptors
  • Environmental chemicals
  • Hormones
  • Epigenetics

Published Papers (4 papers)

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Research

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Open AccessArticle Bisphenol A Exposure and Sperm ACHE Hydroxymethylation in Men
Int. J. Environ. Res. Public Health 2019, 16(1), 152; https://doi.org/10.3390/ijerph16010152
Received: 29 November 2018 / Revised: 29 December 2018 / Accepted: 1 January 2019 / Published: 8 January 2019
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Abstract
Exposure to bisphenol A (BPA) has been shown to impact human sperm quality. The epigenetic mechanisms underlying the effect remain unknown. The acetylcholinesterase (ACHE) gene is a sperm-expressed gene encoding the acetylcholine hydrolyzing enzyme acetylcholinesterase and participates in the apoptosis of cells, including [...] Read more.
Exposure to bisphenol A (BPA) has been shown to impact human sperm quality. The epigenetic mechanisms underlying the effect remain unknown. The acetylcholinesterase (ACHE) gene is a sperm-expressed gene encoding the acetylcholine hydrolyzing enzyme acetylcholinesterase and participates in the apoptosis of cells, including sperm. This study aimed to examine whether BPA exposure is associated with the hydroxymethylation level of the sperm ACHE gene. A total of 157 male factory workers were studied, among whom 74 had BPA exposure in the workplace (BPA exposure group) and 83 had no BPA exposure in the workplace (control group). Urine samples were collected for BPA measurement and semen samples were collected to assay for ACHE hydroxymethylation. Sperm ACHE hydroxymethylation level was higher in the BPA exposure group (p = 0.041) compared to the control group. When subjects were categorized according to tertiles of detected BPA level, higher ACHE hydroxymethylation levels were observed for the lowest, middle, and top tertiles compared to those with BPA below the limit of detection (LOD). In a linear regression analysis adjusted for confounders, a positive linear association between urine BPA concentration and 5-hydroxymethylcytosine (5hmC) rate of the sperm ACHE gene was observed, although the association did not reach statistical significance in all categories after being stratified by the BPA tertile. In conclusion, 5hmC of the sperm ACHE gene was positively associated with BPA exposure, which may provide supportive evidence for BPA’s effects on male fertility or other health endpoints. Full article
(This article belongs to the Special Issue Endocrine Disruptors Exposure on Human Health)
Open AccessArticle Dialysis Membranes Influence Perfluorochemical Concentrations and Liver Function in Patients on Hemodialysis
Int. J. Environ. Res. Public Health 2018, 15(11), 2574; https://doi.org/10.3390/ijerph15112574
Received: 21 October 2018 / Revised: 13 November 2018 / Accepted: 15 November 2018 / Published: 17 November 2018
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Abstract
Introduction: Perfluoro-octanesulfonate (PFOS) and perfluoro-octanoic acid (PFOA) are two toxic perfluorochemicals (PFCs) commonly used as surfactants. PFCs are difficult to be eliminated from the body. We investigated the influence of different dialysis membranes on the concentrations of PFCs in patients under hemodialysis. [...] Read more.
Introduction: Perfluoro-octanesulfonate (PFOS) and perfluoro-octanoic acid (PFOA) are two toxic perfluorochemicals (PFCs) commonly used as surfactants. PFCs are difficult to be eliminated from the body. We investigated the influence of different dialysis membranes on the concentrations of PFCs in patients under hemodialysis. Method: We enrolled 98 patients. Of these, 58 patients used hydrophobic polysulfone (PS) dialysis membranes, and the other 40 had hydrophilic membranes made by poly-methyl methacrylate (PMMA) or cellulose triacetate (CTA). Liquid chromatography tandem mass spectrometry coupled was used with isotope dilution to quantify PFOA and PFOS. Results: The predialysis concentrations of PFOA and PFOS in patients with hydrophobic PS dialysis membranes were 0.50 and 15.77 ng/mL, respectively, lower than the concentrations of 0.81 and 22.70 ng/mL, respectively, in those who used hydrophilic membranes (such as CTA or PMMA). Older patients have higher PFOS and poorer body function, with lower Karnofsky Performance Status Scale (KPSS) scores. The demographic data of the two groups were similar. However, patients with hydrophobic PS dialysis membranes had lower predialysis aspartate transaminase (AST) (p = 0.036), lower glucose levels (p = 0.017), and better body function (nonsignificantly higher KPSS scores, p = 0.091) compared with patients who used other membranes. These differences may be associated with the effects of different membranes, because PFOA positively correlated with AST, while PFOS negatively correlated with body function. Conclusions: This is the first study comparing PFC levels in uremic patients with different dialysis membrane. PS membrane may provide better clearance of PFCs and may, therefore, be beneficial for patients. Full article
(This article belongs to the Special Issue Endocrine Disruptors Exposure on Human Health)
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Open AccessArticle Effects of Bisphenol A and 4-tert-Octylphenol on Embryo Implantation Failure in Mouse
Int. J. Environ. Res. Public Health 2018, 15(8), 1614; https://doi.org/10.3390/ijerph15081614
Received: 3 July 2018 / Revised: 26 July 2018 / Accepted: 27 July 2018 / Published: 30 July 2018
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Abstract
Miscarriage due to blastocyst implantation failure occurs in up to two-thirds of all human miscarriage cases. Calcium ion has been shown to be involved in many cellular signal transduction pathways as well as in the regulation of cell adhesion, which is necessary for [...] Read more.
Miscarriage due to blastocyst implantation failure occurs in up to two-thirds of all human miscarriage cases. Calcium ion has been shown to be involved in many cellular signal transduction pathways as well as in the regulation of cell adhesion, which is necessary for the embryo implantation process. Exposure to endocrine-disrupting chemicals (EDs) during early gestation results in disruption of intrauterine implantation and uterine reception, leading to implantation failure. In this study, ovarian estrogen (E2), bisphenol A (BPA), or 4-tert-octylphenol (OP), with or without ICI 182,780 (ICI) were injected subcutaneously from gestation day 1 to gestation day 3 post-coitus. The expression levels of the calcium transport genes were assessed in maternal uteri and implantation sites. The number of implantation sites was significantly low in the OP group, and implantation sites were absent in the E2, ICI and EDs + ICI groups. There were different calcium transient transport channel expression levels in uterus and implantation site samples. The levels of TRPV5 and TRPV6 gene expression were significantly increased by EDs with/without ICI treatment in utero. Meanwhile, TRPV5 and TRPV6 gene expression were significantly lower in implantation sites samples. NCX1 and PMCA1 mRNA levels were significantly decreased by OP and BPA in the implantation site samples. Compared to vehicle treatment in the uterus, both the MUC1 mRNA and protein levels were markedly high in all but the BPA group. Taken together, these results suggest that both BPA and OP can impair embryo implantation through alteration of calcium transport gene expressions and by affecting uterine receptivity. Full article
(This article belongs to the Special Issue Endocrine Disruptors Exposure on Human Health)
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Review

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Open AccessReview Persistent Organic Pollutant-Mediated Insulin Resistance
Int. J. Environ. Res. Public Health 2019, 16(3), 448; https://doi.org/10.3390/ijerph16030448
Received: 21 December 2018 / Revised: 25 January 2019 / Accepted: 31 January 2019 / Published: 3 February 2019
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Abstract
Persistent organic pollutants (POPs) such as organochlorine (OC) pesticides, polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) have become wide-spread environmental contaminants as a consequence of their extensive use, long-range transport, and persistence. Because POPs are highly resistant to metabolic degradation, [...] Read more.
Persistent organic pollutants (POPs) such as organochlorine (OC) pesticides, polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) have become wide-spread environmental contaminants as a consequence of their extensive use, long-range transport, and persistence. Because POPs are highly resistant to metabolic degradation, humans bioaccumulate these lipophilic and hydrophobic pollutants in fatty tissues for many years. Previous studies have demonstrated that POPs including PCBs are involved in the development of diabetes mellitus (DM) type 2 and insulin resistance. Numerous epidemiological studies suggest an association between POP burden and DM type 2/metabolic syndrome. In addition, several experimental studies have provided additional evidence supporting the association between POP exposure and DM type 2 or insulin resistance. Epidemiological and experimental studies have provided compelling evidence indicating that exposure to POPs increases the risk of developing insulin resistance and metabolic disorders. However, the detailed molecular mechanism underlying POP-induced insulin resistance is yet to be elucidated. In this article, we review literature that has reported on the association between POP burden and insulin resistance and the mechanism underlying POP-induced insulin resistance, and discuss implications for public health. Full article
(This article belongs to the Special Issue Endocrine Disruptors Exposure on Human Health)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Effects of exposure to bisphenol A on memory function and neuroimmune biomarkers in allergic asthmatic mice

Author: Tin Tin Win Shwe

Affiliation: Health Effect Assessment Section, Center for Health and Environmental Risk Research, National Institute for Environmental Studies

 

Title: Critically ill patients are considerably exposed to endocrine disrupting plasticizers

Type: review

Author: Philippe Jorens

Abstract: Leaching of plasticizers i.e. phthalates (especially DEHP) from indwelling medical devices used in the neonatal, pediatric and adult intensive care unit (ICU) exposes the critically ill to these chemicals at levels far exceeding tolerable daily dose recommendations. Phthalates have toxic effects on i.e. neuronal and pulmonary cells, and are, based on in vitro and in vivo data, recognized as endocrine disruptors. Despite that, they are still used in many medical devices. Based on these pathophysiological effects, exposure to these plasticizers during the ICU stay might contribute to the short term as well long-term complications observed in critically ill patients.

Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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