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Advances in Stroke Research: Risk Factors, Prevention and Prognosis
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Advances in Stroke Research: Risk Factors, Prevention and Prognosis

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Disease Prevention".

Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 6470

Special Issue Editors

Dr. Dariusz Kotlȩga

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Guest Editor
1. Department of Pharmacology and Toxicology, University of Zielona Gora, 65-001 Zielona Góra, Poland
2. Elderly and Stroke Medicine, Northampton General Hospital, Cliftonville, Northampton NN1 5BD, UK
Interests: neurology; stroke; care
Special Issues, Collections and Topics in MDPI journals
Dr. Marta Masztalewicz

E-Mail Website
Guest Editor
Department of Neurology, Pomeranian Medical University, 71252 Szczecin, Poland
Interests: stroke; inflammation; immunology; neuropathology; atherosclerosis
Prof. Dr. Małgorzata Szczuko

E-Mail Website
Guest Editor
Department of Human Nutrition and Metabolomics, Pomeranian Medical University, 71-460 Szczecin, Poland
Interests: nutrition; inflammation; metabolism; diabetes; microbiome; short-chain fatty acids; vitamins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ischemic stroke is the main cause of disability in adults and is also a significant cause of death. Public health policies and physicians focus on controlling and modifying the evident risk factors aiming to achieve better prevention strategies. In addition to the commonly considered cardiovascular risk factors, particular attention should be paid to the issues of inflammation, nutrition, physical activity, and lifestyle as important risk factors contributing to stroke. Inflammation is a physiological response of the host to infectious or sterile tissue damage with the primary purpose of restoring tissue homeostasis. However, failure in the regulation of inflammation underlies the pathogenesis of several disorders, including stroke. Various cellular pathways and endogenously generated mediators are involved in the inflammatory process occurring in stroke pathogenesis. We are especially interested in cytokines, lipid mediators, eikozanoids, and the dietary aspects related to this issue. In the current Special Issue, “Advances in Stroke Research: Risk Factors, Prevention and Prognosis”, we invite researches to submit high-quality, original research and review articles addressing the molecular and cellular aspects regarding the risk factors, prevention, and assessing the prognosis. We also encourage authors to submit original articles that analyze the classic cardiovascular factors associated with this topic.

Dr. Dariusz Kotlȩga
Dr. Marta Masztalewicz
Prof. Dr. Małgorzata Szczuko
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • epidemiology
  • physical activity
  • risk assessment
  • eikozanoids
  • lipid mediators
  • inflammation
  • diet

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Published Papers (2 papers)

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Research

11 pages, 657 KiB  
Article
Respiratory Parameters as Predictors of Balance and Gait Ability in Patients with Stroke at Discharge
by Hee-Yong Park, Oh-Yun Kwon, Chung-Hwi Yi, Hye-Seon Jeon, Woochol Joseph Choi, So-Young Ahn and Ui-Jae Hwang
Int. J. Environ. Res. Public Health 2023, 20(23), 7098; https://doi.org/10.3390/ijerph20237098 - 22 Nov 2023
Viewed by 2247
Abstract
Pulmonary complications are frequent in stroke, contributing to both mortality and morbidity rates. Respiratory parameters in such patients encompass both pulmonary function and respiratory muscle strength. Identifying respiratory function variables that influence the balance and gait ability of patients with stroke is crucial [...] Read more.
Pulmonary complications are frequent in stroke, contributing to both mortality and morbidity rates. Respiratory parameters in such patients encompass both pulmonary function and respiratory muscle strength. Identifying respiratory function variables that influence the balance and gait ability of patients with stroke is crucial for enhancing their recovery in these aspects. However, no study has assessed predictions for a comprehensive array of balance and gait abilities in such patients. We aimed to examine whether initial respiratory muscle strength and pulmonary function can predict balance and gait ability at discharge from a rehabilitation program. Thirty-one patients with stroke were included in this prospective observational study. Multiple regression models with a forward selection procedure were employed to identify respiratory parameters (including peak expiratory flow and maximal expiratory pressure) that contributed to the results of balance assessments and gait evaluations at the time of discharge. The peak expiratory flow (PEF) served as a predictor explaining 42.0% of the variance. Similarly, the maximal expiratory pressure (MEP) was a predictor variable explaining 32.0% of the variance. PEF and MEP assessments at the initial stage as predictive factors for both balance and gait ability are important in stroke management. Full article
(This article belongs to the Special Issue Advances in Stroke Research: Risk Factors, Prevention and Prognosis)
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12 pages, 839 KiB  
Article
Neutrophil-to-Lymphocyte Ratio as a Predictor of Short-Term Functional Outcomes in Acute Ischemic Stroke Patients
by Min-Su Kim, Min Young Heo, Hyo Jin Joo, Ga Yang Shim, Jinmann Chon, Sung Joon Chung, Yunsoo Soh and Myung Chul Yoo
Int. J. Environ. Res. Public Health 2023, 20(2), 898; https://doi.org/10.3390/ijerph20020898 - 4 Jan 2023
Cited by 8 | Viewed by 3290
Abstract
Background: Neutrophil-to-lymphocyte ratio (NLR), a systemic inflammatory biomarker, has been associated with poorer outcomes in acute ischemic stroke patients. The present study was designed to expand these findings by investigating the association between NLR and short-term functional outcomes in acute ischemic stroke patients. [...] Read more.
Background: Neutrophil-to-lymphocyte ratio (NLR), a systemic inflammatory biomarker, has been associated with poorer outcomes in acute ischemic stroke patients. The present study was designed to expand these findings by investigating the association between NLR and short-term functional outcomes in acute ischemic stroke patients. Methods: This retrospective study evaluated patients within 7 days after the onset of acute ischemic stroke. Stroke severity on admission was measured using the National Institutes of Health Stroke Scale (NIHSS). The functional outcomes were assessed using the Berg Balance Scale (BBS), Manual Function Test (MFT), the Korean version of the modified Barthel Index (K-MBI), and the Korean Mini-Mental State Examination (K-MMSE) within 2 weeks of stroke onset. The modified Rankin Scale (mRS) was evaluated at discharge. Results: This study included 201 patients, who were grouped into three NLR tertiles (<1.84, 1.84–2.71, and >2.71) on admission. A multivariate analysis showed that the top tertile group (NLR > 2.71) had significantly higher risks of unfavorable outcomes on the K-MBI (p = 0.010) and K-MMSE (p = 0.029) than the bottom tertile group (NLR < 1.84). Based on the optimal cut-off values from a receiver operating characteristic curve analysis, a higher NLR was significantly associated with higher NIHSS scores (p = 0.011) and unfavorable outcomes on the K-MBI (p = 0.002) and K-MMSE (p = 0.001). Conclusions: A higher NLR is associated with poorer short-term functional outcomes in acute ischemic stroke patients. Full article
(This article belongs to the Special Issue Advances in Stroke Research: Risk Factors, Prevention and Prognosis)
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