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Clinical Neuropsychology: Role in Health Care and Services
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Clinical Neuropsychology: Role in Health Care and Services

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Care Sciences & Services".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 6579

Special Issue Editor

Dr. Valerio Pisani

E-Mail Website
Guest Editor
Neurology and Neurorehabilitation Unit, I.R.C.C.S. “Santa Lucia” Foundation, Via Ardeatina 306, 00179 Rome, Italy
Interests: neuropsychology; neurodegeneration; self-rated disability; clinical assessment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Clinical neuropsychology is a discipline that aims to study the impairment of cognitive abilities and emotional–motivational deficits caused by lesions or dysfunctions of the central nervous system. In-depth knowledge of neural circuitry and cognitive functions may help in the evaluation, diagnosis and rehabilitation of people with cognitive disorders. Currently, the validation of more specific and sensitive cognitive scales with normative data worldwide may help clinicians to compare data related to a group of patients with a specific disease. However, cognitive evaluations are often influenced by mood state (e.g., anxiety, depression and apathy), thus creating significant bias in the final results. Indeed, the expansion of knowledge in research through the use of neuroimaging in large study cohorts is constantly transferred to clinical practice, and the clinical observation of patients often provides insights for new experimental research.

This Special Issue of the International Journal of Environmental Research and Public Health (IJERPH) focuses on the utility of even more specific brief cognitive assessment in daily clinical practice in hospitals and how this can help medical teams to accurately monitor cognitive dysfunction and possibly in starting cognitive rehabilitation. Moreover, it would be useful if authors could highlight the problems encountered during cognitive evaluations and how they faced and then solved them to achieve good and reliable final results.

You are welcome to submit new research papers and reviews to this issue. Other acceptable manuscript types include methodological papers, position papers, brief reports, and commentaries.

I look forward to receiving your contributions.

Dr. Valerio Pisani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cognitive assessment
  • neurodegenerative disease
  • disability
  • mood
  • self-rated questionnaire
  • social status
  • cognitive decline

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Published Papers (2 papers)

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11 pages, 1018 KiB  
Article
Emotional Recognition and Its Relation to Cognition, Mood and Fatigue in Relapsing–Remitting and Secondary Progressive Multiple Sclerosis
by Ornella Argento, Chiara Piacentini, Michela Bossa and Ugo Nocentini
Int. J. Environ. Res. Public Health 2022, 19(24), 16408; https://doi.org/10.3390/ijerph192416408 - 7 Dec 2022
Cited by 2 | Viewed by 2007
Abstract
(1) Background: Emotional recognition (ER), the ability to read into others’ minds and recognize others’ emotional states, is important in social environment adaptation. Recently it has been found that ER difficulties affect patients with multiple sclerosis (pMS) and relate to different gray matter [...] Read more.
(1) Background: Emotional recognition (ER), the ability to read into others’ minds and recognize others’ emotional states, is important in social environment adaptation. Recently it has been found that ER difficulties affect patients with multiple sclerosis (pMS) and relate to different gray matter atrophy patterns from secondary progressive (SP-pMS) and relapsing–remitting (RR-pMS). The aim of this study was to compare the performances of the two MS phenotypes on the Reading the Mind in the Eyes test (RMEt) and other cognitive, mood and fatigue measures. We also examined associations between performance on the RMEt and cognitive, mood and fatigue variables. (2) Methods: A total of 43 pMS (27RR-pMS/16SP-pMS) underwent a clinical assessment, the RMEt, the cognitive battery, and completed mood and fatigue questionnaires. Both groups’ performances on the RMEt were then correlated with all these measures. (3) Results: the RMEt scores of RR-pMS were significantly correlated with the impairment degree in some cognitive scores. SP-pMS scores correlated mainly with fatigue, anxiety, anger and depression. (4) Conclusions: ER performances relate to cognitive aspects in RR-pMS, whereas mainly to mood outcomes in the SP-pMS group. We can hypothesize that deficits in ER are a further sign of disease progression. Our data support the different roles of cognitive and emotional deficits related to different disease courses and lesional correlates. Full article
(This article belongs to the Special Issue Clinical Neuropsychology: Role in Health Care and Services)
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Review

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14 pages, 644 KiB  
Review
Locus Coeruleus Dysfunction and Trigeminal Mesencephalic Nucleus Degeneration: A Cue for Periodontal Infection Mediated Damage in Alzheimer’s Disease?
by Flavio Pisani, Valerio Pisani, Francesca Arcangeli, Alice Harding and Sim K. Singhrao
Int. J. Environ. Res. Public Health 2023, 20(2), 1007; https://doi.org/10.3390/ijerph20021007 - 5 Jan 2023
Cited by 5 | Viewed by 3730
Abstract
Alzheimer’s disease (AD) is a leading neurodegenerative disease with deteriorating cognition as its main clinical sign. In addition to the clinical history, it is characterized by the presence of two neuropathological hallmark lesions; amyloid-beta (Aβ) and neurofibrillary tangles (NFTs), identified in the brain [...] Read more.
Alzheimer’s disease (AD) is a leading neurodegenerative disease with deteriorating cognition as its main clinical sign. In addition to the clinical history, it is characterized by the presence of two neuropathological hallmark lesions; amyloid-beta (Aβ) and neurofibrillary tangles (NFTs), identified in the brain at post-mortem in specific anatomical areas. Recently, it was discovered that NFTs occur initially in the subcortical nuclei, such as the locus coeruleus in the pons, and are said to spread from there to the cerebral cortices and the hippocampus. This contrasts with the prior acceptance of their neuropathology in the enthorinal cortex and the hippocampus. The Braak staging system places the accumulation of phosphorylated tau (p-tau) binding to NFTs in the locus coeruleus and other subcortical nuclei to precede stages I–IV. The locus coeruleus plays diverse psychological and physiological roles within the human body including rapid eye movement sleep disorder, schizophrenia, anxiety, and depression, regulation of sleep-wake cycles, attention, memory, mood, and behavior, which correlates with AD clinical behavior. In addition, the locus coeruleus regulates cardiovascular, respiratory, and gastrointestinal activities, which have only recently been associated with AD by modern day research enabling the wider understanding of AD development via comorbidities and microbial dysbiosis. The focus of this narrative review is to explore the modes of neurodegeneration taking place in the locus coeruleus during the natural aging process of the trigeminal nerve connections from the teeth and microbial dysbiosis, and to postulate a pathogenetic mechanism due to periodontal damage and/or infection focused on Treponema denticola. Full article
(This article belongs to the Special Issue Clinical Neuropsychology: Role in Health Care and Services)
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