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Infectious Disease Reports
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Epidemiology, Prevention and Research on Dengue Virus
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Epidemiology, Prevention and Research on Dengue Virus

A special issue of Infectious Disease Reports (ISSN 2036-7449). This special issue belongs to the section "Viral Infections".

Deadline for manuscript submissions: closed (31 December 2025) | Viewed by 2444

Special Issue Editor

Prof. Dr. Alessandro Bartoloni

E-Mail Website
Guest Editor
Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy
Interests: infectious diseases; neglected tropical diseases; antibiotic resistance; tropical medicine

Special Issue Information

Dear Colleagues,

Dengue infection is a significant global health threat, affecting tropical and subtropical regions in particular. As stated by the World Health Organization (WHO), it is one of the main causes of illness and mortality in several Latin American and Asian countries. It is estimated that about half of the world’s population is currently at risk of dengue, with 100 to 400 million cases being recorded annually. Climate change, population growth, international travel, and trade have resulted in important changes in the epidemiology and spread of the disease in recent years. Nevertheless, alongside the continuous spread and increase of dengue cases worldwide, new achievements in terms of management, prevention, and surveillance have been reached as well.

This Special Issue, "Epidemiology, Prevention and Research on Dengue Virus", will feature articles focused on current epidemiological scenarios of the dengue virus worldwide, as well as research works and updates on clinical and diagnostic aspects, vaccines, and other prevention strategies. Manuscripts structured as short communications, original research papers, and reviews on this subject will be considered by the Editorial Office and evaluated for their suitability to undergo revision.

The aim of this Special Issue of Infectious Disease Reports is to favor the rapid publication and dissemination of research data, with the objective of promoting the progress of scientific and clinical knowledge in the field of dengue infection. This will allow for the obtention of reliable and updated information to guide clinicians in the management and prevention of dengue, as well as policy makers in the implementation of adequate surveillance and control strategies.

Prof. Dr. Alessandro Bartoloni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Infectious Disease Reports is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dengue
  • vaccines
  • prevention
  • travel
  • arboviruses
  • epidemiology

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Published Papers (2 papers)

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Research

32 pages, 5723 KB  
Article
Comparative Molecular Docking and Pharmacokinetic Profiling of Cinnamic Acid and Oleic Acid from Cinnamomum verum as Potential Inhibitors of Dengue Virus Proteins
by Wafaa Hussien Habeeb, Noor Hameed Hanoush, Meena Thaar Alani, Ali Hazim Abdulkareem, Mohammed Obaid Ibrahim, Mohammed Salih Al-Janaby, Mohammed Mukhles Ahmed, Saja Saadallah Abduljaleel and Zaid Mustafa Khaleel
Infect. Dis. Rep. 2026, 18(2), 26; https://doi.org/10.3390/idr18020026 - 26 Mar 2026
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Abstract
Background: Dengue virus (DENV) does not have any effective antiviral therapy. The Cinnamomum verum has cinnamic acid and oleic acid that could inhibit important viral proteins. Aim: To compare their inhibitory capacity with the key DENV proteins through molecular docking, molecular dynamics and [...] Read more.
Background: Dengue virus (DENV) does not have any effective antiviral therapy. The Cinnamomum verum has cinnamic acid and oleic acid that could inhibit important viral proteins. Aim: To compare their inhibitory capacity with the key DENV proteins through molecular docking, molecular dynamics and in silico ADMET. Methods: Phytochemical profiling of the ethanolic extract of the bark was done by GCMS. AutoDock Vina (version 1.2.0) was used to dock cinnamic acid and oleic acid to key proteins of DENV (NS5, NS3, and envelope) in the presence of ribavirin as the reference. The best complexes were then subjected to 50 ns of molecular dynamics simulation and stability measured by RMSD, RMSF, Rg, SASA, hydrogen bonding and RDF. Validated in silico tools were used to predict the ADMET properties. Results: Analysis of GC–MS revealed cinnamic acid (85.92%) and oleic acid (5.33%). The outcome of docking was that the cinnamic acid had the greatest affinity with NS5 (−5.970 kcal/mol) and the capsid protein (−5.755 kcal/mol), and oleic acid showed the highest affinity with the capsid (−6.150 kcal/mol) and then with NS5 (−5.209 kcal/mol). Both ligands had a relatively weak interaction with NS3. Simulation of the molecular dynamics showed the stability of the top complexes, especially the cinnamic acid–NS5 complex, that retained low RMSD (1.6–1.9 A), stable Rg and SASA profiles, and continued hydrogen bonding during the 50 ns period. The use of cinnamic acid in ADMET projections was more preferable, as it was more soluble, orally bioavailable (0.91), and drug-like (QED 0.65), but oleic acid revealed higher lipophilicity and lower drug-like properties (QED 0.29). Conclusions: Cinnamic acid showed specificity towards the NS5 proteins with the help of stable dynamics and good predicted pharmacokinetics, which are features that make it a promising multi-target anti-DENV scaffold. Oleic acid exhibited poor affinity and poor pharmacokinetic properties. The findings are predictive and must be validated using biochemical, cellular, and toxicological means to prove the antiviral efficacy and safety. Full article
(This article belongs to the Special Issue Epidemiology, Prevention and Research on Dengue Virus)
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11 pages, 636 KB  
Article
Imported Dengue Fever in Milan, Italy: A Seven-Year Retrospective Study
by Margherita Eleonora Pieruzzi, Davide Mileto, Alessandra Helen Behring, Stefania Caronni, Alessandro Mancon, Luigi Vezzosi, Alberto Rizzo, Andrea Poloni, Andrea Gori, Andrea Giacomelli and Spinello Antinori
Infect. Dis. Rep. 2025, 17(5), 113; https://doi.org/10.3390/idr17050113 - 12 Sep 2025
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Abstract
Background: Dengue fever is an arboviral infection transmitted by Aedes mosquitoes that has recently become a public health concern also in Europe, causing many outbreaks of autochthonous cases. Methods: We retrospectively retrieved dengue cases in returning travelers from tropical areas diagnosed at the [...] Read more.
Background: Dengue fever is an arboviral infection transmitted by Aedes mosquitoes that has recently become a public health concern also in Europe, causing many outbreaks of autochthonous cases. Methods: We retrospectively retrieved dengue cases in returning travelers from tropical areas diagnosed at the Luigi Sacco Hospital between January 2018 and December 2024. All patients with positive serology for DENV (IgM alone or IgM and IgG or neutralizing antibodies detection) and/or positive real-time polymerase chain reaction (RT-PCR) for DENV RNA on plasma and urine were considered. Analyses were descriptive. Results: This analysis included 159 travelers with confirmed (n = 138; 86.8%) or probable (n = 21; 13.2%) dengue fever. The median age was 38 years (interquartile range [IQR] 30–50); 87 (54.7%) were females. The median time between symptom onset and seeking medical attention was four days (IQR 3–6); 29.6% required hospitalization, with a median stay of four days (IQR 0–5). The most common symptoms included fever (100%), myalgia (52.2%), and headache (49.1%). Laboratory findings revealed thrombocytopenia (53.8%), leukopenia (64.1%), elevated ALT (51.9%), and LDH (60.2%). Among the confirmed cases, 128 (92.8%) were diagnosed with RT-PCR. Serotypes 1 and 2 were the most prevalent (28.9% and 27.3%, respectively). Most cases were classified as dengue without warning signs (150, 94.3%), eight cases (5.0%) as dengue with warning signs, and one as severe dengue. Conclusions: Dengue fever is an important cause of fever among travelers returning to Italy from endemic areas. Although severe dengue is rare among travelers, further prospective studies need to address this issue. Diagnosis should be pursued by using molecular tools because of cross-reactivity with other arboviruses. Full article
(This article belongs to the Special Issue Epidemiology, Prevention and Research on Dengue Virus)
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