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Infectious Disease Reports, Volume 17, Issue 6

2025 December - 17 articles

Cover Story: Since its discovery in 2009, Candida auris has emerged as a formidable nosocomial pathogen. One reason for its disease burden is the rapid acquisition of multidrug resistance by the fungus, rendering traditional therapies, such as amphotericin B, ineffective. The long timeline of antifungal development prompted us to explore the potential of repurposing existing clinical agents outside of infectious diseases for the treatment of C. auris infections. Our study found that hypochlorous acid, chlorhexidine, sodium hypochlorite, ethyl pyruvate, and EDTA were all able to disrupt the planktonic and biofilm states of clinical C. auris isolates in vitro. This work highlights a promising, cost-effective strategy to improve outcomes for patients with C. auris infections while underscoring the need for further research into new therapeutic approaches. View this paper
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Articles (17)

  • Article
  • Open Access
1,189 Views
12 Pages

18 December 2025

Background: Respiratory syncytial virus (RSV) pneumonia is an underrecognized cause of critical illness in adults. However, the influence of biological sex on intensive care unit (ICU) outcomes in this population remains unclear. Due to limited case...

(This article belongs to the Section Viral Infections)
  • Article
  • Open Access
1 Citations
1,376 Views
18 Pages

Beyond the Spike Glycoprotein: Mutational Signatures in SARS-CoV-2 Structural Proteins

  • Emil Tonon,
  • Riccardo Cecchetto,
  • Virginia Lotti,
  • Anna Lagni and ,
  • Erica Diani,
  • Asia Palmisano,
  • Marco Mantoan,
  • Livio Montesarchio,
  • Francesca Palladini and
  • Davide Gibellini
  • + 6 authors+ 1 author

18 December 2025

Background: The continuous emergence of SARS-CoV-2 variants represents a major public health concern. Next-generation sequencing (NGS) enables genomic surveillance, facilitating the detection and monitoring of mutations that impact viral evolution. M...

(This article belongs to the Section Viral Infections)
  • Article
  • Open Access
1 Citations
4,705 Views
14 Pages

Factors Associated with Condomless Anal Sex and Absence of Pre-Exposure Prophylaxis (PrEP) Use Among Brazilian Men Who Have Sex with Men: A Cross-Sectional Study

  • Laelson Rochelle Milanês Sousa,
  • Patrícia Thais Cardoso da Silva,
  • Allan Araujo Rodrigues,
  • Márcio José dos Santos Silva and ,
  • José Carlos Vinícius Jansen de Paz,
  • Breno da Silva Oliveira,
  • Daniel de Macêdo Rocha,
  • Maria Wiklander,
  • Elucir Gir and
  • Renata Karina Reis
  • + 5 authors+ 0 author

12 December 2025

Background: Men who have sex with men (MSM) in Brazil remain disproportionately affected by HIV. Combination prevention strategies, including Pre-Exposure Prophylaxis (PrEP), are critical, yet adherence remains a challenge. This study aimed to identi...

(This article belongs to the Special Issue Containment Strategies of Infectious Diseases: Epidemiology, Surveillance and Prophylaxis)
  • Review
  • Open Access
4 Citations
2,194 Views
26 Pages

The Evolution of Artificial Intelligence in Ocular Toxoplasmosis Detection: A Scoping Review on Diagnostic Models, Data Challenges, and Future Directions

  • Dodit Suprianto,
  • Loeki Enggar Fitri,
  • Ovi Sofia,
  • Akhmad Sabarudin and ,
  • Wayan Firdaus Mahmudy,
  • Muhammad Hatta Prabowo and
  • Werasak Surareungchai
  • + 2 authors+ 0 author

8 December 2025

Ocular Toxoplasmosis (OT), a leading cause of infectious posterior uveitis, presents significant diagnostic challenges in atypical cases due to phenotypic overlap with other retinochoroiditides and a reliance on expert interpretation of multimodal im...

  • Case Report
  • Open Access
1 Citations
1,666 Views
8 Pages

When Fever Strikes Twice: A Case Report of Streptococcus pneumoniae Myelitis with Delayed-Onset Reactive Arthritis

  • Rosario Luca Norrito,
  • Sergio Mastrilli,
  • Felice Fiorello,
  • Giuseppe Taormina and ,
  • Lucia Di Giorgi,
  • Grazia Mery Anna Ruggirello,
  • Carlo Domenico Maida,
  • Aurelio Piazza and
  • Fabio Cartabellotta
  • + 4 authors+ 0 author

8 December 2025

Background:Streptococcus pneumoniae is a well-known pathogen responsible for respiratory and invasive diseases; however, central nervous system (CNS) involvement in the form of bacterial myelitis is exceedingly rare, particularly in immunocompetent a...

(This article belongs to the Section Bacterial Diseases)
  • Review
  • Open Access
1 Citations
1,108 Views
18 Pages

Integration Models for Delivering COVID-19 Vaccines Through HIV Services in Low-and Middle-Income Countries: A Scoping Review

  • Nyanyiwe Masingi Mbeye,
  • Roselyn Chipojola,
  • Susan Banda,
  • Prince Kaude and ,
  • Aaron Mdolo,
  • Charles Nwosisi and
  • Sandra Mounier-Jack
  • + 2 authors+ 0 author

5 December 2025

Background: The Coronavirus Disease 2019 (COVID-19) remains a major global public health issue. People living with HIV (PLHIV) are among the vulnerable groups facing a higher risk of severe outcomes. Combining COVID-19 vaccination with HIV services c...

  • Article
  • Open Access
1,016 Views
17 Pages

Epidemiological Profile and Diagnostic Outcomes of Blood Donors Following Hepatitis B Screening at the Largest Blood Bank in the State of Pará, Brazil

  • Núbia Caroline Costa de Almeida,
  • Beatriz Monteiro Rodrigues Coelho,
  • Camila Fonseca Barroso,
  • Carlos Eduardo de Melo Amaral and ,
  • Renata Bezerra Hermes de Castro,
  • Letícia Martins Lamarão,
  • Jacqueline Cortinhas Monteiro,
  • Lucimar Di Paula dos Santos Madeira and
  • Igor Brasil-Costa
  • + 4 authors+ 0 author

28 November 2025

Background/Objectives: Serological and molecular screening for Hepatitis B virus (HBV) has been essential in reducing the risk of transfusion-transmitted infection, particularly in regions of high endemicity. This retrospective study aimed to analyze...

  • Article
  • Open Access
1 Citations
1,539 Views
9 Pages

27 November 2025

Background: Candida auris is an emerging nosocomial fungal pathogen whose inherent multidrug resistance and ability to form biofilms make treatment extremely difficult. Given the limited number of therapeutic options available and the poor clinical o...

  • Case Report
  • Open Access
1 Citations
2,735 Views
9 Pages

Atypical Blistering Manifestation of Secondary Syphilis: Case Report and Review of Reported Cases

  • Agnieszka Markiewicz,
  • Aleksandra Skórka and
  • Agnieszka Owczarczyk-Saczonek

18 November 2025

Background/Objectives: Secondary syphilis typically presents with a non-pruritic maculopapular rash. However, vesicular and bullous manifestations are exceedingly rare in adults and may mimic autoimmune blistering diseases. The objective of this repo...

(This article belongs to the Section Sexually Transmitted Diseases)
  • Article
  • Open Access
1 Citations
1,560 Views
11 Pages

13 November 2025

Background: The duration of protection that COVID-19 vaccination provides against severe outcomes remains uncertain. Accurately defining this timeframe is critical for informing effective vaccination policies and booster strategies. This investigatio...

(This article belongs to the Section Immunology and Vaccines)
  • Article
  • Open Access
1 Citations
1,248 Views
14 Pages

A Comparison of the Risk of Viral Load Blips in Human Immunodeficiency Virus Patients on Two-Drug Versus Three-Drug Antiretroviral Regimens

  • Kimihiro Yamaguchi,
  • Masashi Ishihara,
  • Yoshikazu Ikoma,
  • Hitomi Sugiyama and ,
  • Daichi Watanabe,
  • Kei Fujita,
  • Shin Lee,
  • Tetsuji Morishita,
  • Nobuhiro Kanemura and
  • Hisashi Tsurumi
  • + 6 authors+ 1 author

12 November 2025

Background/Objectives: The objective of this retrospective, multicenter cohort study was to compare the incidence of viral load blips between two-drug and three-drug antiretroviral therapy regimens in human immunodeficiency virus (HIV) patients. Meth...

  • Case Report
  • Open Access
1 Citations
1,740 Views
9 Pages

A Rare Case of Disseminated Nocardia transvalensis in an Immunocompetent Host

  • Branavan Ragunanthan,
  • Kevin Wunderly,
  • James Kleshinski and
  • Caitlyn Hollingshead

12 November 2025

Background: Nocardia are a group of bacteria known to cause pulmonary, cutaneous, neurologic, or disseminated diseases, usually in immunocompromised hosts. Within the Nocardia family is Nocardia transvalensis, a rarely encountered and underreported o...

(This article belongs to the Section Bacterial Diseases)
  • Article
  • Open Access
3 Citations
2,563 Views
13 Pages

Epidemiological and Clinical Changes in RSV-Associated Pneumonia in Children in Mexico Before and During the COVID 19 Pandemic

  • Ilen Adriana Diaz-Torres,
  • Isamu Daniel Cabrera-Takane,
  • Fanny Yasmin Ortega-Vargas,
  • Aldo Agustin Herrera-González and ,
  • Miguel Leonardo Garcia-León,
  • Patricia Bautista-Carbajal,
  • Daniel E. Noyola,
  • Maria Susana Juárez-Tobías,
  • Pedro Antonio Martínez-Arce and
  • Rosa María Wong-Chew
  • + 9 authors+ 4 authors

8 November 2025

Background/Objectives: Respiratory syncytial virus (RSV) significantly affects young children. In 2020, at the beginning of the COVID-19 pandemic, widespread public health measures temporarily interrupted RSV transmission. However, by mid-2021, an at...

(This article belongs to the Special Issue Viral Infectious Diseases: Epidemiology and Prevention Through Vaccination)
  • Article
  • Open Access
2 Citations
1,073 Views
12 Pages

4 November 2025

Background/Objectives: Healthcare and social workers were at increased risk of infection during the COVID-19 pandemic, and were therefore also at increased risk of long-term physical and mental health consequences due to infection. This study aimed t...

  • Case Report
  • Open Access
3,828 Views
11 Pages

Difficult-to-Treat Skin and Soft Tissue Infections Caused by Panton-Valentine Leukocidin-Producing Community-Associated Methicillin-Resistant Staphylococcus aureus: A Case Series

  • Luca Pipitò,
  • Chiara Vincenza Mazzola,
  • Giulio D’Agati,
  • Eleonora Bono and ,
  • Raffaella Rubino,
  • Silvia Bonura,
  • Claudia Gioè,
  • Teresa Fasciana and
  • Antonio Cascio
  • + 4 authors+ 0 author

3 November 2025

Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has emerged as a genetically distinct lineage from healthcare-associated MRSA (HA-MRSA), often producing Panton-Valentine leukocidin (PVL) and causing severe skin...

  • Article
  • Open Access
1 Citations
1,693 Views
9 Pages

24 October 2025

Background: Methicillin-resistant Staphylococcus aureus (MRSA) colonization is a risk factor for potential staphylococcal infection and outbreaks. Although it is recommended to obtain a swab culture to detect nasal colonization its necessity in low-p...

(This article belongs to the Special Issue Prevention, Diagnosis and Treatment of Healthcare-Associated Infections)
  • Article
  • Open Access
3,053 Views
12 Pages

Molecular Characterization of Chlamydia trachomatis Infection and Its Impact on Sperm Characteristics of Moroccan Infertile Men

  • Mariame Kabbour,
  • Modou Mamoune Mbaye,
  • Bouchra Ghazi,
  • Achraf Zakaria and ,
  • Rajaa Ait Mhand,
  • Noureddine Louanjli and
  • Moncef Benkhalifa
  • + 2 authors+ 0 author

22 October 2025

Background/Objectives: Infections of the urogenital tract have experienced renewed interest in recent years, due to their frequency and also their impact on sperm parameters and the fertilizing quality of spermatozoa. Chlamydia trachomatis (CT) repre...

(This article belongs to the Section Sexually Transmitted Diseases)
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Infect. Dis. Rep. - ISSN 2036-7449