Advances in Neuroimaging Genetics

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Technologies and Resources for Genetics".

Deadline for manuscript submissions: closed (5 December 2021) | Viewed by 2309

Special Issue Editor


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Guest Editor
Division of Neurogenetics and Neurodevelopmental Pediatrics, Children’s National Hospital and the George Washington University School of Medicine and Health Sciences, Washington, DC 20010, USA
Interests: neuroimaging; inborn errors of metabolism; neurogenetics; neuroscience; neurodevelopmental disorders, genetics

Special Issue Information

Dear Colleagues,

In recent years, a multitude of brain mapping techniques has been used to try to establish a connection between anatomic differences in structure and/or neural circuitry in the brain, phenotypes, and individual variations in the human genome. Several studies have suggested converging evidence that brain imaging can establish relationships between genes and behavior. The use of multimodal imaging has implications to study underlying neurobiological and neuroanatomical mechanisms that influence behavioral phenotypes or disease states. In the process of doing so, intermediate or less severe phenotypes may be uncovered.

This Special Issue on “Advances in Neuroimaging Genetics” will provide a broad overview on how multimodal neuroimaging modalities are being used to understand the role that imaging can play in deciphering the genetic underpinnings of cognition, behavior and brain. The integration of genetic and neuroimaging data is full of possibilities but not without consideration of methodological and conceptual challenges. This Special Issue reviews recent advances in the field and identifies important methodological and conceptual challenges that remain unresolved in the attempt to fully exploit the synergism of imaging and genetics; authors are encouraged to submit papers describing this synergism.

Dr. Andrea L. Gropman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Brain mapping
  • Imaging genetics
  • Neuroimaging
  • Multimodal
  • MRI
  • fMIR
  • Diffusion tensor (DTI)
  • Magnetic resonance spectroscopy (MRS)
  • fNIRs

Published Papers (1 paper)

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Review

10 pages, 681 KiB  
Review
Review of Applications of Near-Infrared Spectroscopy in Two Rare Disorders with Executive and Neurological Dysfunction: UCD and PKU
by Kosar Khaksari, Wei-Liang Chen and Andrea L. Gropman
Genes 2022, 13(10), 1690; https://doi.org/10.3390/genes13101690 - 21 Sep 2022
Cited by 3 | Viewed by 1896
Abstract
Studying rare diseases, particularly those with neurological dysfunction, is a challenge to researchers and healthcare professionals due to their complexity and small population with geographical dispersion. Universal and standardized biomarkers generated by tools such as functional neuroimaging have been forged to collect baseline [...] Read more.
Studying rare diseases, particularly those with neurological dysfunction, is a challenge to researchers and healthcare professionals due to their complexity and small population with geographical dispersion. Universal and standardized biomarkers generated by tools such as functional neuroimaging have been forged to collect baseline data as well as treatment effects. However, the cost and heavily infrastructural requirement of those technologies have substantially limited their availability. Thus, developing non-invasive, portable, and inexpensive modalities has become a major focus for both researchers and clinicians. When considering neurological disorders and diseases with executive dysfunction, EEG is the most convenient tool to obtain biomarkers which can correlate the objective severity and clinical observation of these conditions. However, studies have also shown that EEG biomarkers and clinical observations alone are not sensitive enough since not all the patients present classical phenotypical features or EEG evidence of dysfunction. This article reviews disorders, including two rare disorders with neurological dysfunction and the usefulness of functional near-infrared spectroscopy (fNIRS) as a non-invasive optical modality to obtain hemodynamic biomarkers of diseases and for screening and monitoring the disease. Full article
(This article belongs to the Special Issue Advances in Neuroimaging Genetics)
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