Special Issue "Mitochondrial Genomes: Genetic and Transcriptomic Studies"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Technologies and Resources for Genetics".

Deadline for manuscript submissions: 15 January 2019

Special Issue Editors

Guest Editor
Prof. Yan Guo

Department of Internal Medicine, University of New Mexico, Albuquerque, NM, 87131, USA.
Website | E-Mail
Interests: genomics; genetics; bioinformatics; mitochondria; data mining; machine learning; high throughput genomic data
Guest Editor
Dr. Sergey Ivanov

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Website | E-Mail
Interests: genome evolution; cancer genetics and metabolism; mitochondria; diabetes

Special Issue Information

Dear Colleagues,

Mitochondria are small double membraned bound organelles found in almost every cell of all organisms. They are primarily responsible for energy production. Typically, there are approximately 100 mitochondria in each mammalian cell, and each mitochondrion harbors 2–10 copies of mitochondrial DNA. The human mitochondria genome is a double-stranded circular DNA molecule, consisting of 16,569 nucleotides. It contains 13 protein-coding genes, 22 transfer RNAs (tRNAs), and two ribosomal RNAs. Mitochondrial DNA (mtDNA) is maternally inherited, thus its genome is haploid. However, many sites in mitochondria DNA are heteroplasmic, containing two alleles. Mitochondrial DNA variants have been linked to various diseases and important biological processes, such as cancer, aging, etc. Mitochondrial research is on the rise across multiple fields in the medical sciences. Especially with the rise of high throughput sequencing, researchers now can examine mitochondria genome in unprecedented detail. In this Special Issue, we would like to invite researchers to share their latest work on the following mitochondria related (without being limited to) topics:

  • Mitochondrial sequence analysis
  • Mitochondrial mutations related to diseases or trait
  • Mitochondrial mechanisms related to diseases or trait
  • Mitochondrial heteroplasmy analysis
  • Biotechnology aspects related to mitochondria research
  • Bioinformatics, statistical aspects of mitochondria research

Prof. Yan Guo
Dr. Sergey Ivanov
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mitochondrial sequence analysis
  • mitochondrial mutations related to diseases or trait
  • mitochondrial mechanisms related to diseases or trait
  • mitochondrial heteroplasmy analysis
  • biotechnology aspects related to mitochondria research
  • bioinformatics, statistical aspects of mitochondria research

Published Papers (1 paper)

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Research

Open AccessArticle Assembly of the Mitochondrial Genome in the Campanulaceae Family Using Illumina Low-Coverage Sequencing
Received: 28 June 2018 / Revised: 24 July 2018 / Accepted: 25 July 2018 / Published: 30 July 2018
Cited by 1 | PDF Full-text (3463 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Platycodon grandiflorus (balloon flower) and Codonopsis lanceolata (bonnet bellflower) are important herbs used in Asian traditional medicine, and both belong to the botanical family Campanulaceae. In this study, we designed and implemented a de novo DNA sequencing and assembly strategy to map the
[...] Read more.
Platycodon grandiflorus (balloon flower) and Codonopsis lanceolata (bonnet bellflower) are important herbs used in Asian traditional medicine, and both belong to the botanical family Campanulaceae. In this study, we designed and implemented a de novo DNA sequencing and assembly strategy to map the complete mitochondrial genomes of the first two members of the Campanulaceae using low-coverage Illumina DNA sequencing data. We produced a total of 28.9 Gb of paired-end sequencing data from the genomic DNA of P. grandiflorus (20.9 Gb) and C. lanceolata (8.0 Gb). The assembled mitochondrial genome of P. grandiflorus was found to consist of two circular chromosomes; the master circle contains 56 genes, and the minor circle contains 42 genes. The C. lanceolata mitochondrial genome consists of a single circle harboring 54 genes. Using a comparative genome structure and a pattern of repeated sequences, we show that the P. grandiflorus minor circle resulted from a recombination event involving the direct repeats of the master circle. Our dataset will be useful for comparative genomics and for evolutionary studies, and will facilitate further biological and phylogenetic characterization of species in the Campanulaceae. Full article
(This article belongs to the Special Issue Mitochondrial Genomes: Genetic and Transcriptomic Studies)
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