Special Issue "microRNAs and Other Non-Coding RNAs in Human Diseases"
Deadline for manuscript submissions: closed (30 September 2016).
Prof. Dr. Muller Fabbri
Departments of Pediatrics and Molecular Microbiology & Immunology, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Saban Research Institute, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA, USA
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Interests: microRNAs, long non-coding RNAs, exosomes and extracellular vesicles, cancer, inflammation, tumor microenvironment, immunity
One of the most unexpected and fascinating discoveries in oncology over the past few years is the interplay between abnormalities in protein-coding genes and noncoding RNAs (ncRNAs) that is causally involved in cancer initiation, progression, and dissemination. MicroRNAs (miRNAs), small regulatory ncRNAs, are involved in the Pathogenesis of all types of human cancers, as well as in many other human disorders, mainly via dysregulation of expression of cancer genes. Increasing evidence shows that miRNAs can work as oncogenes (activating malignant potential) or tumor suppressors (inhibiting malignant potential). Understanding the roles of miRNAs and other ncRNAs in diseases is not only uncovering a new layer of gene regulation but also providing new markers for improved diagnosis and prognosis, as well as novel therapeutic options for patients. In a single issue of Genes in Spring of 2017, we would like to focus on the roles of microRNAs and long non-coding RNAs in human diseases, highlighting what is already known about their function and describing the challenges for the near future development of biomarkers and new Therapeutics.
Prof. Dr. George A Calin
Dr. Muller Fabbri
Manuscript Submission Information
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