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Special Issue "Epigenetics, Environment, and Brain Disorders"
Deadline for manuscript submissions: closed (15 November 2018).
Department of Biological Sciences, Fordham University, Bronx, New York, USA
Interests: epigenetic mechanisms in normal brain function, behavior and psychiatric disorders; environmental effects on the brain; brain sexual dimorphism; neuroendocrinology
In the last 15 years, the brain epigenome has emerged as a biological substrate through which environmental and genetic risk factors can interact to bring about brain disorders. Numerous studies have shown that epigenomes of brain cells are dynamic and responsive to environmental cues throughout life. Epigenetic gene regulation is essential for normal brain development and, therefore, epigenetic disruption early in life can lead to lasting consequences for brain function and behavior. The brain epigenome continues to be plastic in the adolescent period and adulthood, further providing a substrate through which environmental exposures can affect brain gene expression, structure, and function. Although the current evidence strongly supports the epigenetic link between environmental risk factors and brain disorders, the issues of causality and underlying mechanisms have still to be addressed more thoroughly. In addition, many new issues in the neuroepigenetics field have recently been highlighted including: Sex-, brain region- and cell type-specificity; specific windows of exposure; the relevance of peripheral epigenetic markers for brain studies; cross-generational epigenetic effects. We invite investigators to contribute original research articles, review articles, or short commentaries that will further stimulate the development of this field and provide new ideas on how to use this knowledge to improve our understanding of brain disorders, their diagnosis, early interventions, and treatments. Both animal and human studies are encouraged. Potential topics for this Special Issue may include, but are not limited to:
- effects of environmental exposures including stress, toxicants, drugs, nutrition, and viral infections on the brain epigenome and behavior throughout life;
- sex-specific epigenetic (dys)regulation in the brain;
- epigenome editing in the brain;
- inter- and trans-generational epigenetic effects of environmental exposures of relevance to brain and behavior;
- peripheral epigenetic markers of environmental exposures of relevance to neurodevelopment and adult-onset brain disorders;
- new methods and recommendations for future studies in neuroepigenetics and environmental epigenetics;
- epigenetic changes and mechanisms in brain disorders.
Prof. Dr. Marija Kundakovic
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- DNA methylation
- Histone modification
- Toxicological exposures
- Drugs of abuse
- Brain disorders