Epigenetics and Chromosome Biology
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (1 September 2020) | Viewed by 5364
Special Issue Editors
Interests: transcription; chromatin; DNA topology and conformation; MYC
Interests: transcriptional regulation; RNA pol II pausing; O-GlcNAcylation; MYC
Special Issue Information
Dear Colleagues,
Besides conducting their fundamental in vivo actions, transcription, replication, and DNA repair must contend with the chromatin environment. This environment likely consists of several different scales of regulation and organization and includes the primary packaging of DNA into chromatin and associated histone post-translational modifications. The plethora of histone covalent modifications and the enzymes that place or remove them have deep impacts on the biology and pathology of virtually all eukaryotes. Besides directly governing classical intermolecular recognition, the stereochemical arrangement and chemical state of nucleosomes may contribute to the folding and spatial partitioning of genes and chromosomal segments, subject to the physics of the transmission of force and torque through DNA and chromatin and to the physical chemical constraints of phase separations within the nucleus while also accommodating the biochemical events surrounding transcription, DNA replication, and DNA repair. It is this imposition of multiple, independent layers of regulation and organization on gene regulation, repair, and replication that confers robustness and plasticity to these events.
Prof. David L. Levens
Dr. Brian A. Lewis
Dr. Fedor Kouzine
Guest Editors
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Keywords
- transcription
- chromatin
- DNA topology and conformation
- epigenetics and nuclear architecture
- MYC
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