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Special Issue "Chromatin Dynamics"
Deadline for manuscript submissions: closed (30 April 2015).
Interests: Chromatin assembly, histone modifications, chromatin remodeling, DNA double strand break repair, replicative aging
Special Issues and Collections in MDPI journals
Our understanding of chromatin has increased exponentially since German anatomist Walther Flemming first coined the word in 1879 to describe the readily stainable substance in a cell nucleus. We now know that chromatin is highly dynamic, mediated via histone post-translational modifications, DNA methylation, histone variants, ATP-dependent nucleosome remodeling, higher order chromatin compaction, and inter- and intra-chromosome interactions. The central function of chromatin dynamics is to reveal, or block, access to specific DNA sequences in a manner that is dependent on the particular stage of the cell cycle, development, differentiation, and environment of the cell. In doing so, chromatin dynamics enables the cell to tightly regulate all the fundamental activities of the genome, including DNA replication, transcription, repair, recombination, and mitosis. Not surprisingly, many human diseases are caused when the machinery that mediates chromatin dynamics goes awry. In a single issue of Genes in Spring of 2015, we would like to summarize the current state of our understanding of chromatin dynamics by showcasing the best research from around the world. We welcome reviews and original articles in the area of chromatin dynamics, including causal studies relating disruption of the machinery that modulates chromatin remodeling to human disease.
Prof. Dr. Jessica Tyler
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- chromatin remodeling
- histone variants
- histone modifications
- histone chaperones
- chromosome territories