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Super Enhancers in Cancers, Complex Disease, and Developmental Disorders

1
Medical Scientist Training Program, Medical School, University of Michigan, Ann Arbor, MI 48109, USA
2
Department of Human Genetics, Medical School, University of Michigan, Ann Arbor, MI 48109, USA
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Department of Computational Medicine and Bioinformatics, Medical School, University of Michigan, Ann Arbor, MI 48109, USA
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Department of Pediatrics and Communicable Diseases, Medical School, University of Michigan, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Jessica Tyler
Genes 2015, 6(4), 1183-1200; https://doi.org/10.3390/genes6041183
Received: 9 July 2015 / Revised: 24 October 2015 / Accepted: 26 October 2015 / Published: 9 November 2015
(This article belongs to the Special Issue Chromatin Dynamics)
Recently, unique areas of transcriptional regulation termed super-enhancers have been identified and implicated in human disease. Defined by their magnitude of size, transcription factor density, and binding of transcriptional machinery, super-enhancers have been associated with genes driving cell differentiation. While their functions are not completely understood, it is clear that these regions driving high-level transcription are susceptible to perturbation, and trait-associated single nucleotide polymorphisms (SNPs) occur within super-enhancers of disease-relevant cell types. Here we review evidence for super-enhancer involvement in cancers, complex diseases, and developmental disorders and discuss interactions between super-enhancers and cofactors/chromatin regulators. View Full-Text
Keywords: super-enhancer; stretch enhancer; transcription; cancer; complex disease; developmental disorder super-enhancer; stretch enhancer; transcription; cancer; complex disease; developmental disorder
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MDPI and ACS Style

Niederriter, A.R.; Varshney, A.; Parker, S.C.J.; Martin, D.M. Super Enhancers in Cancers, Complex Disease, and Developmental Disorders. Genes 2015, 6, 1183-1200.

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