One, Two, Three: Polycomb Proteins Hit All Dimensions of Gene Regulation
Abstract
:1. Introduction
2. Hierarchy vs. Plasticity for More Flexibility in Repression?
2.1. Canonical Two-Step Mechanism of Repression
2.2. Non-Canonical Mechanisms of Repression
3. Various Ways to Hunt for Targets
4. On the Path from 1D to 3D
4.1. Never Walk Alone—Polycomb and Chromatin Domains
4.2. PcG and Chromatin Fiber Packaging
4.3. It Takes Two to Tango—Chromatin Loops Mediated by PcG Proteins
5. In the Third Dimension: Polycomb Mediates Higher Order Chromatin Organization
5.1. Polycomb and Topologically Associating Domains
5.2. Polycomb Clustering
5.3. Polycomb Regulation and Spatial Distribution
6. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Del Prete, S.; Mikulski, P.; Schubert, D.; Gaudin, V. One, Two, Three: Polycomb Proteins Hit All Dimensions of Gene Regulation. Genes 2015, 6, 520-542. https://doi.org/10.3390/genes6030520
Del Prete S, Mikulski P, Schubert D, Gaudin V. One, Two, Three: Polycomb Proteins Hit All Dimensions of Gene Regulation. Genes. 2015; 6(3):520-542. https://doi.org/10.3390/genes6030520
Chicago/Turabian StyleDel Prete, Stefania, Pawel Mikulski, Daniel Schubert, and Valérie Gaudin. 2015. "One, Two, Three: Polycomb Proteins Hit All Dimensions of Gene Regulation" Genes 6, no. 3: 520-542. https://doi.org/10.3390/genes6030520