Next Article in Journal / Special Issue
Epigenetic Heterogeneity of B-Cell Lymphoma: DNA Methylation, Gene Expression and Chromatin States
Previous Article in Journal
Genotype-Epigenotype Interaction at the IGF2 DMR
Previous Article in Special Issue
Chromatin Dynamics in Vivo: A Game of Musical Chairs
Open AccessReview

Chromatin Insulators and Topological Domains: Adding New Dimensions to 3D Genome Architecture

1
Department of Bioengineering and Therapeutic Sciences, Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA
2
Department of Ophthalmology, Lab for Retinal Cell Biology, University of Zurich, Wagistrasse 14, Zurich 8952, Switzerland
*
Authors to whom correspondence should be addressed.
Academic Editor: Jessica Tyler
Genes 2015, 6(3), 790-811; https://doi.org/10.3390/genes6030790
Received: 8 June 2015 / Revised: 10 August 2015 / Accepted: 20 August 2015 / Published: 1 September 2015
(This article belongs to the Special Issue Chromatin Dynamics)
The spatial organization of metazoan genomes has a direct influence on fundamental nuclear processes that include transcription, replication, and DNA repair. It is imperative to understand the mechanisms that shape the 3D organization of the eukaryotic genomes. Chromatin insulators have emerged as one of the central components of the genome organization tool-kit across species. Recent advancements in chromatin conformation capture technologies have provided important insights into the architectural role of insulators in genomic structuring. Insulators are involved in 3D genome organization at multiple spatial scales and are important for dynamic reorganization of chromatin structure during reprogramming and differentiation. In this review, we will discuss the classical view and our renewed understanding of insulators as global genome organizers. We will also discuss the plasticity of chromatin structure and its re-organization during pluripotency and differentiation and in situations of cellular stress. View Full-Text
Keywords: insulators; architectural proteins; TAD boundaries; chromatin architecture insulators; architectural proteins; TAD boundaries; chromatin architecture
Show Figures

Figure 1

MDPI and ACS Style

Matharu, N.K.; Ahanger, S.H. Chromatin Insulators and Topological Domains: Adding New Dimensions to 3D Genome Architecture. Genes 2015, 6, 790-811.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop