Molecular Insights into Centromere Assembly and Dysfunction
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (30 July 2021) | Viewed by 3185
Special Issue Editors
Interests: genetics; chromosomal instability; aneuploidy; cell cycle; cancer genetics;
Special Issue Information
Dear Colleagues,
We would like to invite you to contribute to this Special Issue of Genes titled “Molecular Insights into Centromere Assembly and Dysfunction”.
The aim of this Special Issue is to collect reviews and original research articles that advance our understanding of the mechanisms responsible for centromere assembly and dysfunction. We welcome author contributions highlighting novel findings on the assembly of the centromere, its (epi)genetic regulation, the molecular mechanisms operating at the centromere, and causes of centrosome dysfunction/malfunction associated with chromosome stability and their roles in human diseases. Centromeres are unique chromosome loci characterized by the binding of a special histone H3 variant known as CENP-A in vertebrates, Cse4 in Saccharomyces cerevisiae, Cid in Drosophila melanogaster, and HCP-3 in Caenorhabditis elegans. Here, the kinetochore complex adheres and sister chromatids are held together ensuring the faithful segregation in mitosis and meiosis. Hence, the correct assembly (protein composition, (epi)genetic background, integrity, localization, topology, and regulation) of the centromere is essential for the maintenance of chromosome (genome) stability. Unsurprisingly, therefore, alterations of centromeres, such as increased expression and mislocalization of CENP-A, have been reported in human diseases including cancer. This evidence highlights the importance of centromere studies for human health.
Prof. Aldo Di Leonardo
Dr. Viviana Barra
Guest Editors
Manuscript Submission Information
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Keywords
- Centromere
- Kinetochore
- Centromeric proteins
- Genomic instability
- Epigenetics
- Chromosome
- Repetitive DNA
- Centromere misregulation
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