Non-coding RNAs on the Tumorigenesis and Metastatic Processes in Cancer
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "RNA".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2621
Special Issue Editors
Interests: gene regulation; epigenetics; non-coding RNAs; cancer; lung diseases
Special Issues, Collections and Topics in MDPI journals
Interests: non-coding RNAs; bioinformatics algorithms; spatial transcriptomics; data integration; cancer data analysis
Special Issue Information
Dear Colleagues,
Non-coding RNAs (ncRNAs) are protein-free RNAs produced by genome transcription. There are approximately 20,000 genes encoded in the human genome, of which 40–90% are estimated to be regulated by miRNA. A variety of RNAs, including small non-coding RNAs (miRNAs/miRs, piRNAs) and long non-coding RNAs (lncRNAs), regulate gene expression at the transcription, post-transcription and epigenetic levels. During the last decade, the discovery of non-coding RNAs’ deregulation in different cancer cells has been the focus of attention for numerous investigations. The emergence of deep sequencing technologies has generated a high volume of public data to further explore the role of ncRNAs, as well as epigenetic modifications (i.e., chromatin remodeling), in the early diagnosis and stratification of patients. Therefore, there is a large amount of interest in the study of non-coding RNAs and epigenetic regulators in order to personalize clinical practice and be able to apply more specific and effective treatments to cancer patients.
Cancer is one of the most prevalent human diseases, affecting millions of people every year worldwide and having a high mortality rate. In recent years, with the development of molecular biology and new technologies, especially genome sequencing, the mechanism of action of lncRNAs in various types of cancer has been gradually revealed, and the study of ncRNAs has been significantly augmented for various cancer types. For instance, lncRNAs are involved in the biological behavior and signaling pathways of metastatic pancreatic cancer, including the cell cycle, apoptosis, autophagy, epithelial–mesenchymal transition (EMT) and cancer stem cells (CSCs). The present review focuses on the characteristics and biological roles of the most described ncRNAs (miRNAs, lncRNAs, piRNAs and circRNAs), with particular emphasis on their implication in cancer.
This Special Issue aims to shed some light on the use of novel candidates for tumor identification and to describe strategies involving non-coding RNAs and epigenetic modifications in cancer, as well as new advances obtained in clinics. Original research manuscripts and comprehensive reviews are welcome.
Dr. Elena Lopez-Jimenez
Dr. Eduardo Andrés-León
Guest Editors
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Keywords
- ncRNA
- cancer
- miRNAs
- lncRNAs
- gene expression regulation
- epigenetics
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