Application of Data Science in Cancer

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".

Deadline for manuscript submissions: closed (5 March 2023) | Viewed by 2596

Special Issue Editors

Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW 2145, Australia
Interests: machine learning; bioinformatics; computer vision; multi-omics; cancer

E-Mail Website
Guest Editor
IBM Research Europe, 8803 Rüschlikon, Switzerland
Interests: machine learning; interpretable deep learning; multi-omics data integration; mechanistic models; cancer immunotherapies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer data science fueled by machine learning has facilitated a plethora of biomedical studies, improved cancer diagnosis and prognosis and led to ground-breaking discoveries in precision medicine. Many computational methods have been developed to address important biological and clinical questions, such as molecular classification of cancer types and subtypes, cancer vulnerability prediction, and patient stratification. This Special Issue focuses on the application of data science to cancer research. We welcome the submission of both original papers and reviews including, but not limited to, the following topics:

  1. Algorithmic development of machine learning/deep learning for cancer research;
  2. Integration of multi-omics cancer data through machine learning/deep learning;
  3. Clinical applications of cancer data science;
  4. Benchmark studies and re-analysis of existing datasets;
  5. Review of data science methods for cancer research.

Dr. Qing Zhong
Dr. María Rodríguez Martínez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • data science
  • machine learning
  • cancer
  • precision medicine
  • multi-omics
  • bioinformatics
  • computer vision

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 4940 KiB  
Article
HSP70 Expression Signature in Renal Cell Carcinoma: A Clinical and Bioinformatic Analysis Approach
by Noha M. Abd El-Fadeal, Alia Ellawindy, Mohammed A. Jeraiby, Safaa Y. Qusti, Eida M. Alshammari, Ahmad Khuzaim Alzahrani, Ezzat A. Ismail, Ziad Ehab, Eman A. Toraih, Manal S. Fawzy and Marwa Hussein Mohamed
Genes 2023, 14(2), 355; https://doi.org/10.3390/genes14020355 - 30 Jan 2023
Cited by 3 | Viewed by 2036
Abstract
Heat shock proteins (HSPs) are cytoprotective against stressful conditions, as in the case of cancer cell metabolism. Scientists proposed that HSP70 might be implicated in increased cancer cell survival. This study aimed to investigate the HSP70 (HSPA4) gene expression signature in [...] Read more.
Heat shock proteins (HSPs) are cytoprotective against stressful conditions, as in the case of cancer cell metabolism. Scientists proposed that HSP70 might be implicated in increased cancer cell survival. This study aimed to investigate the HSP70 (HSPA4) gene expression signature in patients with renal cell carcinoma (RCC) in correlation to cancer subtype, stage, grade, and recurrence, combining both clinicopathological and in silico analysis approaches. One hundred and thirty archived formalin-fixed paraffin-embedded samples, including 65 RCC tissue specimens and their paired non-cancerous tissues, were included in the study. Total RNA was extracted from each sample and analyzed using TaqMan quantitative Real-Time Polymerase Chain Reaction. Correlation and validation to the available clinicopathological data and results were executed. Upregulated HSP70 (HSPA4) gene expression was evident in RCC compared to non-cancer tissues in the studied cohort and was validated by in silico analysis. Furthermore, HSP70 expression levels showed significant positive correlations with cancer size, grade, and capsule infiltration, as well as recurrence in RCC patients. The expression levels negatively correlated with the overall survival (r = −0.87, p < 0.001). Kaplan–Meier curves showed lower survival rates in high HSP70 expressor group compared to the low expressors. In conclusion, the HSP70 expression levels are associated with poor RCC prognosis in terms of advanced grade, capsule infiltration, recurrence, and short survival. Full article
(This article belongs to the Special Issue Application of Data Science in Cancer)
Show Figures

Graphical abstract

Back to TopTop