Special Issue "Transcriptional and Genetic Tumor Heterogeneity through ScRNA-seq"
Deadline for manuscript submissions: 1 December 2021.
Interests: genomics; transcriptomics; cancer genomics; computational biology; bioinformatics; RNA seq; bioinformatic tools
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By enabling cell-level analyses, scRNA-seq brings major advantages over the bulk RNA-seq approach, including the ability to distinguish cell populations and to assess cell-type specific phenotypes. Connecting these phenotypes to cell-level transcriptional and genetic variation is acknowledged as a critical challenge for phenotype interpretation. In cancer, studies on cell-level heterogeneity have been instrumental in tracing cell lineages and resolving subclonal tumor architecture. Genetically distinct tumor cell populations are shown to differ with respect to clinical features, including growth rate, disease aggressiveness, and sensitivity to drugs. Furthermore, linking genetic to transcriptional heterogeneity has demonstrated the advantages of the integrative analyses to characterize cancer programs and to outline drug-resistance cell populations.
With the quick progress of scRNA-seq technologies, including approaches to assess cell-level genetic heterogeneity, the anticipation is that scRNA-seq will soon be incorporated in the clinics. This process will greatly benefit from improved knowledge on tumor heterogeneity, the ability to interpret cell-level genetic and transcriptional variation, and, consequently, to distinguish and characterize sensitive and resistant clones. In the near future, this new knowledge is expected to be translated into better diagnosis and treatment of cancer patients.
We invite submissions of both methodological and original research papers assessing tumor heterogeneity through single-cell RNA sequencing. Special focus will be placed on research integrating genetic and transcriptional heterogeneity and identifying cell-level genetic determinants of phenotype. The overarching aim of this issue is to stimulate emerging and promising single-cell research, pursuing at the same time new exploratory and collaborative venues to address its challenges.
Dr. Anelia D. Horvath
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- genetic variation
- genetic heterogeneity
- transcriptional heterogeneity
- single-cell RNA sequencing