Current Genetic Insights in Organ Development

Dear Colleagues, 

Organ development involves a synchronized series of morphological and biochemical transformations that are precisely controlled to ensure normal organ growth and function. We now know many genes that drive tissue remodeling during organogenesis, but we still do not fully understand the underlying mechanisms that regulate organogenesis on the genetic, transcriptomic, and epigenetic level. It is still unclear, for example, how organ size is regulated or how an organ becomes functional.

Much of the progress made in unraveling the responsible genetic networks in organ development has come from research in model organisms. Recent developments in gene editing methods, advanced microscopy, and transcriptomics technologies have started to rapidly enhance our understanding in the field. This Special Issue aims at exploring recent and novel insights in the genetics of organ development using a range of model systems and approaches to consolidate frontline research across model organs in one place and stimulate a flow of ideas for future studies. Researchers are invited to contribute original articles or short reports or new methods or reviews or commentaries that address current advances in genetics of organ development on the model organism they study. A particular focus will be on (but not limited to) mutational analysis of previously uncharacterized genes, gene interactions, epigenetic modifications, and gene expression patterns that affect organ development. We further aim at reporting on the cellular and molecular mechanisms through which gene mutations result in developmental aberrations, and how these genes are regulated or dysregulated. 

Dr. Vasilios Tsarouhas
Guest Editor

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