Craniofacial Bone and Dental Genetics, Metabolism, Aging, and Disorders in 2023

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".

Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 1849

Special Issue Editors

Department of Diagnostic & Biomedical Sciences, School of Dentistry,1941 East Road, Houston, TX 77054, USA
Interests: craniofacial tissue development; genetics of craniofacial birth defects; salivary gland development and disorders; computational biology of gene regulation
Special Issues, Collections and Topics in MDPI journals
Department of Basic Sciences at São Paulo State University, Araçatuba School of Dentistry, FOA/UNESP, Araçatuba, São Paulo, Brazil
Interests: bone biology; bone reconstruction; bone metabolism and repair
Special Issues, Collections and Topics in MDPI journals
School of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USA
Interests: oral and maxillofacial surgery; endochondral ossification; bone graft; phenotypic; bone regeneration; musculoskeletal system
Special Issues, Collections and Topics in MDPI journals
1. Department of Periodontics and Dental Hygiene, Board Certified Periodontist-Implant Surgeon, Key Opinion Leader (KOL), MIS Implants Technologies Inc., 18-00 Fair Lawn Ave, Fair Lawn, NJ 07410, USA
2. Ambassador, Academy of Osseointegration, President, Faculty Senate FY2018-2019, School of Dentistry, University of Texas Health Science Center at Houston, 7500 Cambridge Str., Houston, TX 77054, USA
Interests: surgical treatment of periodontal disease and peri-implantitis; implant dentistry; guided bone regeneration; guided tissue regeneration; soft-tissue regeneration

Special Issue Information

Dear Colleagues,

Bone and cartilage are intriguing tissues that constitute most of the vertebrate skeleton in animals. Both tissues consist of multiple specialized cells that respond to intrinsic and extrinsic stimulants and inhibitors to regulate their cell fate and differentiation. Craniofacial bone forms through intramembranous and endochondral ossification processes. In addition, bone remodeling and repair happen throughout our lives to maintain its metabolism, physical integrity, and regeneration capacity. This Special Issue aims to publish manuscripts on recent bone genetics and disorders in model organisms to uncover the gene function and regulatory pathways responsible for craniofacial bone development, regeneration, metabolism, and aging. We encourage investigators to submit their relevant studies on the genetics of bone formation, maturation, regeneration, the effect of sex hormones, and response to cytokines and chemokines. This Special Issue seeks to shed more light on current and advanced technologies and studies on craniofacial bone biology to share their knowledge with the scientific community to improve basic science knowledge and translational approaches.

Dr. Walid Fakhouri
Prof. Dr. Mariza Akemi Matsumoto
Dr. Claudia Cristina Biguetti
Dr. Nikolaos Soldatos
Guest Editors

Manuscript Submission Information

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Keywords

  • bone formation
  • regeneration
  • metabolism
  • sex dimorphism
  • genetic risk factors

Published Papers (1 paper)

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Research

17 pages, 4223 KiB  
Communication
The Significance of Mylohyoid Muscle Release (MMR) in the Vertical and Horizontal Ridge Augmentation Surgeries; Clinical and Human Cadaver Analyses of the Techniques
by Nikolaos Soldatos, Jessica Immonen, Georgios Romanos and Robin Weltman
Genes 2023, 14(3), 595; https://doi.org/10.3390/genes14030595 - 26 Feb 2023
Viewed by 1578
Abstract
(1) Background: Ridge augmentations either horizontal (HRA) or vertical (VRA) in the posterior mandible are very challenging regenerative procedures. To attain and retain tension-free primary closure, buccal periosteal and mylohyoid muscle releases should be performed. The purpose of the present study was to [...] Read more.
(1) Background: Ridge augmentations either horizontal (HRA) or vertical (VRA) in the posterior mandible are very challenging regenerative procedures. To attain and retain tension-free primary closure, buccal periosteal and mylohyoid muscle releases should be performed. The purpose of the present study was to review, analyze and discuss the three different techniques for the mylohyoid muscle release (MMR) in VRA and HRA surgeries on a clinical and human cadaver level. (2) Presentation of the techniques: Three different techniques are described in the literature regarding the lingual flap management: (i) the finger sweep technique (FST), (ii) the release of the mylohyoid muscle attachment on the lingual flap (MMALF), and (iii) the mylohyoid preservation technique (MPT) in three key anatomical zones. All three techniques, even though they use a different approach, can achieve similar amount of horizontal and vertical mylohyoid muscle release although MPT showed statistically significant higher flap advancement. The human cadaver analyses revealed that all three techniques are considered safe since they do not approximate vital anatomical structures. (3) Conclusions: All three techniques are considered safe, but they are not free of limitations or complications; therefore, they should be performed only by highly experienced and trained clinicians. MPT achieved statistically significant higher flap advancement. Full article
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