Maintenance of DNA Structure and Genome Stability
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 25 September 2025 | Viewed by 55
Special Issue Editor
Interests: stalled DNA replication fork rescue; single-molecule studies of DNA motor proteins; DNA helicases; single-stranded DNA binding protein
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The maintenance of genome stability is essential to viability. To achieve this, there are numerous protein–protein complexes required to minimize DNA damage. During the successful duplication of the genome, there is a close interplay between the genetic recombination and DNA replication machinery. This is because replisomes frequently encounter roadblocks resulting in enzymatic train wrecks where replication forks become inactivated. In both prokaryotes and eukaryotes, collisions between rapidly advancing replisomes and slower moving transcription complexes can have disastrous consequences for genome stability if not dealt with properly. This is exacerbated in prokaryotes where transcription and translation are coupled, and collisions with the resulting mega-protein complexes can have disastrous consequences for replisomes. In addition to these collisions impacting genome stability, the formation of unusual DNA structures during DNA replication, as well as the persistence of RNA-DNA hybrids, can also be deleterious to cells. Finally, cells also must deal with exogeneous DNA damage that if left unrepaired may result in cell death or in humans, which can ultimately be observed in the form of cancer or other diseases.
Dr. Piero R. Bianco
Guest Editor
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Keywords
- genome instability
- DNA damage
- replication restart
- recombinational repair
- replication fork
- DNA repair
- recombination
- single-strand binding proteins
- replisomes
- RNA polymerase
- transcription and translation
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