Natural Ingredients for Functional Foods: Advances in Composition, Bioactivity, and Applications

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 10 November 2025 | Viewed by 380

Special Issue Editor


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Guest Editor
Institute of Chemical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 103, 1113 Sofia, Bulgaria
Interests: phytochemistry; plant secondary metabolites; chromatography; spectral methods; development of quantitative methods; exploration of pharmacological activity mechanisms; structure–activity relationships; food supplements; cosmetics
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Special Issue Information

Dear Colleagues,

Natural ingredients with health-promoting properties are at the forefront of functional food innovation. Sourced from botanical origins such as herbs, fruits, and other traditional food materials, these bioactive compounds—including, but not limited to, polyphenols, flavonoids, terpenoids, essential oils, and dietary fibers—are increasingly valued for their potential to enhance human health and reduce the risk of chronic diseases. This Special Issue aims to highlight recent advances in the discovery, characterization, and application of natural ingredients in functional foods, with a strong emphasis on both efficacy and safety. Relevant topics include chemical composition, extraction methods, bioactivity (e.g., antioxidant, anti-inflammatory, antimicrobial, metabolic effects), stability, bioavailability, safety assessment, and regulatory considerations. Studies addressing sustainable sourcing, formulation strategies, and integration into food systems are also welcome. We invite original research, reviews, and short communications that support the development of safe and effective natural functional food ingredients.

Prof. Dr. Daniela Ilieva Batovska
Guest Editor

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Keywords

  • functional foods
  • natural ingredients
  • plant-based bioactives
  • phytochemicals
  • nutraceuticals
  • food antioxidants
  • food safety
  • essential oils
  • phenolic compounds
  • clean-label products
  • bioavailability
  • sustainable food ingredients
  • traditional food sources
  • health-promoting compounds

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Published Papers (1 paper)

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Research

18 pages, 2301 KiB  
Article
Optimization, Structural Characterization, and Bioactivities of Polysaccharides from Rosa roxburghii Tratt Fruit Using Enzyme-Assisted Extraction
by Qing Chen, Yue Zhang, Siyuan Zheng, Siming Zhu and Chao Li
Foods 2025, 14(14), 2423; https://doi.org/10.3390/foods14142423 - 9 Jul 2025
Viewed by 266
Abstract
This study aimed to optimize the enzyme-assisted extraction of polysaccharides (RTFPs) from Rosa roxburghii fruit using response surface methodology. Under the optimal extraction conditions, the yield of RTFPs reached 14.02%, which was close to the predicted value of 13.96%. The primary structural characteristics [...] Read more.
This study aimed to optimize the enzyme-assisted extraction of polysaccharides (RTFPs) from Rosa roxburghii fruit using response surface methodology. Under the optimal extraction conditions, the yield of RTFPs reached 14.02%, which was close to the predicted value of 13.96%. The primary structural characteristics and the antioxidative and immunomodulatory activities of RTFPs were also examined. Structural characterization revealed that RTFPs comprise 36.38% neutral sugar, 48.83% uronic acid, and 7.29% protein. Their heteropolysaccharide structure features two distinct molecular weight fractions (1.87 × 105 Da and 4.75 × 103 Da) and a monosaccharide composition dominated by glucose (38.93%), arabinose (20.66%), galactose (20.58%), galacturonic acid (10.94%), and xylose (6.52%). Antioxidant assays demonstrated potent radical scavenging activity, with IC50 values of 11 μg/mL (DPPH) and 150 μg/mL (ABTS), comparable to conventional antioxidants. Immunomodulatory studies on RAW264.7 macrophages revealed that RTFPs (100–400 μg/mL) significantly enhanced phagocytosis by 12.61–76.63% and stimulated the secretion of nitric oxide (NO) and tumor necrosis factor-α (TNF-α). These bioactivities are attributed to RTFPs’ high uronic acid content, moderate molecular weight distribution, unique monosaccharide profile, and highly branched conformation. Full article
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