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Natural Active Compounds in Foods: Screen, Sources and Health Benefits

A special issue of Foods (ISSN 2304-8158).

Deadline for manuscript submissions: closed (20 February 2026) | Viewed by 4450

Special Issue Editors


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Guest Editor
College of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Interests: food natural products; medicinal and edible homologous variety resources; food nutrition; food health function; algae based food; metabolic engineering; synthetic biology; carotenoid metabolism; food safety; food toxicology

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Guest Editor
College of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Interests: food natural products; essential oil; food nutrition; food health function; food safety; food toxicology; food packaging materials; postharvest preservation of fruits and vegetables

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Guest Editor Assistant
College of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Interests: engineering microbial; food microbiology; carotenoids; microalgae

Special Issue Information

Dear Colleagues,

With the popularity of healthy lifestyles, individials’ attention to the nutritional functions of food has increased. Many bioactive compounds in natural products derived from food (including plants, animals, etc.) have important effects on the human body, promoting health and preventing disease. The functional active ingredients of food include various categories of compounds, such as polyphenols, flavone, alkaloids, saponins, sterols, volatile oils, polysaccharides, and so on. These ingredients have various effects antioxidant, anti-inflammatory, anti-aging, lipid-lowering, hypoglycemic, sedative hypnotic and anti-tumor effects, which aid in the management and prevention of some diseases and are widely employed in healthcare products.

Studying the effective active ingredients in food can help clarify its nutritional value, with these functional compounds also being widely used in the development of nutraceuticals, drugs and beauty and skincare products. Therefore, effectively utilizing food active ingredients has become an important aspect of research in the food industry. By utilizing modern biotechnology and molecular biology methods to screen bioactive compounds, the efficacy, signaling pathways, and targets of these components can be clarified at the cellular and animal levels, providing a powerful tool for in-depth research concerning food active ingredients.

Therefore, this Special Issue of Foods, entitled “Natural Active Compounds in Foods: Screen, Sources and Health Benefits" welcomes the submission of articles whose scope includes, but is not limited to, the following topics:

  • New methods for preparing active natural products and their biological significance.
  • The efficient discovery and diversity mining of the active compounds in food.
  • The biological synthesis and metabolic engineering of food active natural products.
  • The development and utilization of specialty foods, new food resources, and their active ingredients.
  • The screening and identification of Caenorhabditis elegans and food active ingredients.
  • The identification of natural food active product targets and signaling pathways at the cellular and animal levels.

Prof. Dr. Jianguo Jiang
Dr. Liang Zhu
Guest Editors

Dr. Haohong Chen
Guest Editor Assistant

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food active compounds 
  • activity screening 
  • compound preparation 
  • biological synthesis 
  • metabolic engineering 
  • new food resources 
  • Caenorhabditis elegans 
  • screening 
  • targets 
  • signal pathway

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Published Papers (3 papers)

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Research

17 pages, 2322 KB  
Article
Processing Shapes Architecture, Cultivar Dictates Chemistry: A Structural and Functional Paradigm for Yam Polysaccharides
by Yajuan Bai, Bei Fan, Jiameng Liu, Fengzhong Wang and Mingwei Zhang
Foods 2026, 15(5), 921; https://doi.org/10.3390/foods15050921 - 6 Mar 2026
Cited by 1 | Viewed by 414
Abstract
Yam polysaccharides are promising functional food ingredients, but the systematic understanding of how cultivar and processing synergistically determine their structure and functionality is still lacking. This study systematically investigated how hot water extraction, enzymatic hydrolysis, and extrusion puffing affect the structural and functional [...] Read more.
Yam polysaccharides are promising functional food ingredients, but the systematic understanding of how cultivar and processing synergistically determine their structure and functionality is still lacking. This study systematically investigated how hot water extraction, enzymatic hydrolysis, and extrusion puffing affect the structural and functional properties of polysaccharides from two major cultivars (Dioscorea opposite cv. Tiegun and Dioscorea esculenta cv. Gaozhou). Enzymatic extraction increased yield (1.39–1.77-fold) and solubility, while hot water extraction favored purity. The monosaccharide composition was strongly cultivar-dependent, with Tiegun polysaccharides containing higher mannose levels. Extrusion puffing of Gaozhou polysaccharide improved solubility by 33.3% but induced depolymerization and aggregation, modifying colloidal and functional behaviors. Multivariate analysis revealed that processing methods primarily governed macromolecular architecture and colloidal properties, whereas cultivar determined chemical composition. These findings establish a processing–structure–property framework, enabling the tailored production of yam polysaccharides: Tiegun yam with enzymatic extraction for high bioactivity, and Gaozhou yam with extrusion puffing for superior solubility. Full article
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21 pages, 4388 KB  
Article
Antihyperlipidemic Effect of Flavonoids and Saponins from Pyracantha fortuneana Fruits on L02 Cells and Caenorhabditis elegans
by Yunfang Hao, Yinhong Wang, Kexin Hao, Yimeng Li, Longmei Geng, Liang Zhu and Jianguo Jiang
Foods 2025, 14(20), 3499; https://doi.org/10.3390/foods14203499 - 14 Oct 2025
Viewed by 1364
Abstract
In China, Pyracantha fortuneana has been consumed as a nutritious plant to improve indigestion. In the current study, the main chemical composition of P. fortuneana fruits was extracted and analysed for composition. Free fatty acids (FFA)-induced normal human hepatic L02 cells were used [...] Read more.
In China, Pyracantha fortuneana has been consumed as a nutritious plant to improve indigestion. In the current study, the main chemical composition of P. fortuneana fruits was extracted and analysed for composition. Free fatty acids (FFA)-induced normal human hepatic L02 cells were used to construct a high-fat cell model, and lipid deposition in Caenorhabditis elegans was induced by a high concentration of glucose to study the anti-hyperlipidemic effects of the main components. The results showed that the flavonoid content of PFF (P. fortuneana Flavonoid Fractions) was 80.28%, and it contained various flavonoids such as epicatechin, isoquercetin, rutin, quercetin, and myricitrin, while the saponin content of PFS (P. fortuneana Saponin Fractions) was 74.4%, and it contained saponins such as shionone, crategolic acid, and ursolic acid. PFF and PFS significantly reduced the content of lipid droplets in high-fat L02 cells, inhibited mitochondrial membrane potential decline, regulated the fat accumulation by up-regulating the relative mRNA expression levels in the Nrf2/ARE signaling pathway, as well as the CPT-1 and SIRT1 genes in lipid metabolism. Meanwhile, both PFF and PFS significantly reduced lipid deposition, reactive oxygen species (ROS) levels, malondialdehyde (MDA) content, and catalase activity in C. elegans. In summary, our results indicated that the flavonoids and saponins of P. fortuneana are potential natural products in antihyperlipidemic effect. Full article
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16 pages, 2387 KB  
Article
Improvement in Physicochemical and Functional Properties of Insoluble Dietary Fiber from Rice Bran Treated with Different Processing Methods
by Yanxia Chen, Qin Ma, Fei Huang, Xuchao Jia, Lihong Dong, Dong Liu, Mingwei Zhang and Ruifen Zhang
Foods 2025, 14(17), 3116; https://doi.org/10.3390/foods14173116 - 5 Sep 2025
Cited by 3 | Viewed by 2001
Abstract
Rice bran represents an exceptional natural source of dietary fiber (DF), and its physicochemical properties and therapeutic potential are closely associated with its origin and processing methods. Herein, rice bran was subjected to extrusion, fermentation, and a combined treatment of fermentation and extrusion [...] Read more.
Rice bran represents an exceptional natural source of dietary fiber (DF), and its physicochemical properties and therapeutic potential are closely associated with its origin and processing methods. Herein, rice bran was subjected to extrusion, fermentation, and a combined treatment of fermentation and extrusion to explore the alternations in the structural, physicochemical, and functional properties of the resulting insoluble dietary fiber (IDF). All treatments induced substantial microstructural alterations in IDF, producing fiber matrices with enhanced porosity and looser architectures. The employed processing treatments significantly enhanced the functional properties of rice bran IDF over the unprocessed sample, with 1.37- to 1.78-fold increases in oil-holding capacity, 1.31- to 1.48-fold increases in cholesterol-adsorption capacity, 2.89- to 5.90-fold increases in α-amylase-inhibitory activity, and 2.41- to 3.70-fold increases in glucose-adsorption capacity. Among them, extrusion proved more effective than fermentation in enhancing the water-holding capacity, sodium cholate binding, and cholesterol-adsorption capacity of rice bran IDF. However, fermented rice bran-derived IDF exhibited the optimum α-amylase-inhibitory and glucose-absorption capacities among all employed IDF samples. These findings provide valuable insights for the development of rice bran-based functional foods with enhanced health benefits. Full article
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