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The Hidden Power of Milk: Bioactive Compounds and Their Health...
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The Hidden Power of Milk: Bioactive Compounds and Their Health Impacts

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Dairy".

Deadline for manuscript submissions: 17 June 2025 | Viewed by 1248

Special Issue Editors

Dr. Alexandre Lamas

E-Mail Website
Guest Editor
Food Hygiene, Inspection and Control Laboratory (LHICA-USC), Department of Analytical Chemistry, Nutrition and Bromatology, Faculty of Veterinary Science, Campus Terra, Universidade de Santiago de Compostela (USC), 27002 Lugo, Spain
Interests: milk products; functional foods; food-borne pathogens; next-generation sequencing; microbiota; microRNAs
Special Issues, Collections and Topics in MDPI journals
Dr. Patricia Regal

E-Mail Website
Guest Editor
Food Hygiene, Inspection and Control Laboratory (LHICA-USC), Department of Analytical Chemistry, Nutrition and Bromatology, Faculty of Veterinary Science, Campus Terra, Universidade de Santiago de Compostela (USC), 27002 Lugo, Spain
Interests: dairy products; breast milk; functional components; baby food; probiotics; microbiota; food safety; analytical chemistry; omics
Special Issues, Collections and Topics in MDPI journals
Dr. Cristina A. Fente

E-Mail Website
Guest Editor
Food Hygiene, Inspection and Control Laboratory (LHICA-USC), Department of Analytical Chemistry, Nutrition and Bromatology, Faculty of Veterinary Science, Campus Terra, Universidade de Santiago de Compostela (USC), 27002 Lugo, Spain
Interests: breast milk; dairy products; functional components; baby food; probiotics; omics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Milk is a highly complex food that serves as the primary source of nutrients for mammalian offspring. In addition to being a balanced source of macro and micronutrients, it is composed of a whole mix of bioactive compounds, such as immunoglobulins, fatty acids, hormones, bioactive peptides, or microRNAs, which play a key role in the development of offspring. Despite being a food that has been part of our diet for millennia, researchers have not yet fully studied the exact composition and bioactivity of certain components. In recent years, with the increase in interest in functional foods that promote healthy development and life, milk is once again gaining interest as a source of these bioactive compounds. This Special Issue will welcome both research and review papers that evaluate and characterize the presence of bioactive compounds in milk (both in humans and farm animals) and dairy products, the factors that influence their levels, as well as those that evaluate their effects in both in vitro and in vivo studies.

Dr. Alexandre Lamas
Dr. Patricia Regal
Dr. Cristina A. Fente
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • milk
  • dairy product
  • breast milk
  • functional ingredients
  • probiotics
  • bioactive components
  • microbiota
  • microRNAs
  • in vitro studies
  • in vivo studies

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Published Papers (1 paper)

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Research

12 pages, 876 KiB  
Article
Antioxidant and Inflammation-Attenuating Ability of Human Milk, Infant Formulas and Their Oligosaccharides
by Andrea Leong, Christopher Pillidge and Harsharn Gill
Foods 2025, 14(6), 960; https://doi.org/10.3390/foods14060960 - 11 Mar 2025
Viewed by 772
Abstract
Human milk (HM) provides maximum health benefits for infants. This is due in part to the activity of its minor components, including HM proteins and oligosaccharides (HMOs). Where HM is unavailable, infant formulas (IFs) are normally used, the two most common types being [...] Read more.
Human milk (HM) provides maximum health benefits for infants. This is due in part to the activity of its minor components, including HM proteins and oligosaccharides (HMOs). Where HM is unavailable, infant formulas (IFs) are normally used, the two most common types being cow milk- and goat milk-based formulas (CIF and GIF). The aim of this study was to compare the antioxidant properties of HM, CIF and GIF, together with those of their respective oligosaccharides (HMOs, CMOs and GMOs), using in vitro model systems. The ability of these oligosaccharides to attenuate inflammation (expression of IL-1α, TNFα, IL-6 and IL-8) was also assessed using a U937 cell culture model. Results showed that GIF and GMOs exhibited the highest antioxidant potential. The iron-reducing and iron-chelating properties of both IFs were comparable to those for HM, while the iron-chelating ability of the CMOs was lowest. None of the oligosaccharides significantly reduced U937 cytokine expression following induction of inflammation; however, GMOs consistently reduced expression of IL-1α, TNFα and IL-6 to a greater extent than the other oligosaccharides, presumably by competitive binding to immune receptors. In conclusion, GMOs have a greater antioxidant potential than CMOs and may have some inflammation-attenuating ability as well. Full article
(This article belongs to the Special Issue The Hidden Power of Milk: Bioactive Compounds and Their Health Impacts)
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