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Advances in Microbial Polysaccharide Research: Bioactivity, Molecular Mechanisms and Food...
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Advances in Microbial Polysaccharide Research: Bioactivity, Molecular Mechanisms and Food Applications

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1522

Special Issue Editor

Prof. Dr. Peipei Han

E-Mail Website
Guest Editor
State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
Interests: microbial polysaccharides; fermentation production of natural food ingredients; microalgae; microbial technology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microbial polysaccharides (MPs) are biopolymers secreted by microorganisms such as bacteria fungi and algae during metabolic processes. Compared to polysaccharides derived from plants and animals, MPs have advantages such as a wide range of sources, high production efficiency, and less susceptibility to natural environmental influences. The most attractive feature of MPs is their diverse bioactivity such as antioxidative, immunomodulatory, anti-tumor and antibacterial activities, which have demonstrated enormous potential for applications in foods, cosmetics and biomedicine. These bioactivities are precisely regulated by their sophisticated molecular structure. However, the mechanisms underlying this precise regulation are not yet fully understood. Furthermore, MP synthesis processes involve a large number of genes. The key genes of MP synthesis need to be further explored, and the regulatory mechanism of MP synthesis has also not been elucidated.

The aim of this Special Issue is to publish both recent innovative research results and review papers on the advances in microbial polysaccharide research: bioactivity, molecular mechanisms and food applications.

Prof. Dr. Peipei Han
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbial polysaccharides
  • structural-activities relationships
  • bioactivity
  • food industry
  • metabolic engineering
  • polysaccharide synthesis pathway
  • regulation mechanism

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Published Papers (2 papers)

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Research

22 pages, 16108 KiB  
Article
Marine-Derived Enterococcus faecalis HY0110 as a Next-Generation Functional Food Probiotic: Comprehensive In Vitro and In Vivo Bioactivity Evaluation and Synergistic Fermentation of Periplaneta americana Extract Powder
by Feiyun Huang, Nan Yang, Qingqing Zhang, Cuiling Luo, Jingheng Wang, Yu Yang, Bisong Yue, Peng Chen and Xiuyue Zhang
Foods 2025, 14(7), 1181; https://doi.org/10.3390/foods14071181 - 28 Mar 2025
Viewed by 578
Abstract
Addressing the escalating global burdens of inflammatory bowel disease and antimicrobial resistance demanded innovative food-based approaches to fortify gut health and suppress pathogens. We introduced a novel edible probiotic, Enterococcus faecalis HY0110, isolated from marine Thunnus thynnus. Through comprehensive in vitro, in [...] Read more.
Addressing the escalating global burdens of inflammatory bowel disease and antimicrobial resistance demanded innovative food-based approaches to fortify gut health and suppress pathogens. We introduced a novel edible probiotic, Enterococcus faecalis HY0110, isolated from marine Thunnus thynnus. Through comprehensive in vitro, in vivo, and metabolomic analyses, we demonstrated its superior antibacterial effects compared to Lactobacillus rhamnosus GG, along with significantly enhanced antioxidant and free-radical scavenging capacities. Notably, elevated acetic acid production strongly correlated with its antimicrobial efficacy (R ≥ 0.999). HY0110 also exerted antiproliferative effects on HT-29 colorectal cancer cells by attenuating β-catenin and BCL-2 expression while upregulating pro-apoptotic markers P62 and c-PARP. In a DSS-induced colitis model, HY0110 alleviated inflammation, restored gut microbial homeostasis, and enhanced deterministic processes in community assembly dynamics. Furthermore, fermenting Periplaneta americana powder with HY0110 triggered extensive metabolic remodeling, notably a 668.73-fold rise in astragaloside A, plus increases in L-Leucyl-L-Alanine, S-lactoylglutathione, and 16,16-dimethyl prostaglandin A1. These shifts diminished harmful components and amplified essential amino acids and peptides to bolster immune modulation, redox balance, and anti-inflammatory responses. This work established a transformative paradigm for utilizing marine probiotics and novel entomological substrates in functional foods, presenting strategic pathways for precision nutrition and inflammatory disease management. Full article
(This article belongs to the Special Issue Advances in Microbial Polysaccharide Research: Bioactivity, Molecular Mechanisms and Food Applications)
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16 pages, 6829 KiB  
Article
AOX Affects the Synthesis of Polysaccharides by Regulating the Reactive Oxygen Species in Ganoderma lucidum
by Ruiying Zhu, Lele Zhang, Longxi Wu, Jingshuo Liu, Jie Zhang, Jian Li, Kejing Song and Peipei Han
Foods 2025, 14(5), 826; https://doi.org/10.3390/foods14050826 - 27 Feb 2025
Viewed by 477
Abstract
Alternative oxidase (AOX) is a terminal oxidase in the mitochondrial electron transport chain that does not contribute to the generation of ATP. It plays a critical role in maintaining the balance between reactive oxygen species (ROS) production and intracellular redox homeostasis within the [...] Read more.
Alternative oxidase (AOX) is a terminal oxidase in the mitochondrial electron transport chain that does not contribute to the generation of ATP. It plays a critical role in maintaining the balance between reactive oxygen species (ROS) production and intracellular redox homeostasis within the mitochondria. In the study, overexpression and knockdown approaches were employed to investigate the function of AOX. AOX-silenced strains (AOXi3 and AOXi25) and AOX-overexpressed strains (OE-AOX2 and OE-AOX21) were constructed. The ROS level and transcription level of the antioxidant-system-related genes, including phosphoglucomutase (pgm) and phosphomannose isomerase (pmi), were differentially upregulated in silenced strains, whereas the opposite effect was observed in the AOX-overexpressed strains. Compared with the wild type (WT), the polysaccharide production of AOXi25 was significantly increased by approximately 38%, while OE-AOX21 was significantly decreased by 80%. Six extracellular polysaccharides (EPSs) were extracted and purified from the WT, OE-AOX21, and AOXi25 strains. These EPSs, consisting of both neutral and acidic polysaccharides, were composed of five different monosaccharides in varying proportions. The average relative molecular masses were 1.68 × 103, 2.66 × 103, 1.67 × 103, 2.42 × 103, 1.12 × 103, and 2.35 × 103 kDa, respectively. Antioxidant assays demonstrated that all EPSs exhibited strong free radical scavenging activity with the acidic polysaccharide from AOXi25 showing the highest efficiency in ABTS+ scavenging. These findings highlight the significant role of AOX-derived ROS in regulating polysaccharide synthesis and accumulation in Ganoderma lucidum. Full article
(This article belongs to the Special Issue Advances in Microbial Polysaccharide Research: Bioactivity, Molecular Mechanisms and Food Applications)
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