Metabolic Engineering in Microbial Synthesis

Dear Colleagues,

Metabolic engineering in microbial synthesis represents a vanguard discipline within the biotechnological landscape, fundamentally transforming the way valuable compounds are produced through targeted manipulation of microbial metabolic pathways. This pioneering research endeavors to optimize microbial cell factories, rendering them highly proficient in the biosynthesis of biofuels, pharmaceuticals, chemicals, and a myriad of other economically and environmentally significant products. Pivotal advancements in synthetic biology, systems biology, and computational modeling have bestowed upon researchers unparalleled precision and control in the fine-tuning of microbial metabolism. These interdisciplinary synergies have engendered marked enhancements in product yields, substantial reductions in production costs, and the advent of inherently sustainable bioprocess configurations. Consequently, metabolic engineering in microbial synthesis stands as a cornerstone of modern biotechnology, driving continuous innovation in the quest for efficient, cost-effective, and eco-friendly manufacturing of high-value chemicals and materials from renewable biological resources.

The Special Issue invites submissions of original research papers, comprehensive reviews, and insightful perspectives that delve into a broad range of themes within the metabolic engineering of industrial microorganisms, encompassing, but not restricted to, the following areas:

1. Genetic Manipulation and Synthetic Biology for strain improvement
2. Pathway Optimization and Flux Balancing for boosting microbial productivity
3. Metabolite Sensing and Feedback Control for biosynthetic processes
4. Microbial Consortia and Community Engineering for enhancing overall productivity
5. Bioprocess Development and Scale-up for successful translation from the laboratory to industry
6. Novel Tools and Techniques for robustness, stability, and scalability

We aim to stimulate interdisciplinary cooperation and propel the progression of metabolic engineering in the context of microbial synthesis. We extend a warm invitation to researchers and experts in the field to share their groundbreaking contributions within this Special Issue, thereby catalyzing innovation and facilitating the dissemination of knowledge within the rapidly evolving domain of metabolic engineering.

Dr. Libang Zhou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fermentation is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• metabolic engineering
• synthetic biology
• systems biology
• pathway engineering
• microbial cell factories
• fermentation
• industrial biotechnology