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Diseases publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Digital Pathology in Precision Oncology: Emerging Tools for Diagnosis and Treatment Guidance

edited by Daniela Hartmann and

Maximilian Deussing

submission deadline 25 Jun 2026 | 1 articles | Viewed by 1283 | Submission Open

Keywords: oncology; digital pathology; ex vivo confocal microscopy; artificial intelligence; machine learning; virtual biopsy; teledermatology; histopathological images; image analysis algorithms

(This special issue belongs to the Section Oncology)

Functional Foods and Supplements: Special Focus on Mechanisms of Action and Potential Clinical Application

edited by Emilio Jirillo,

Omar Cauli

and

Luigi Santacroce

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1447 | Submission Open

Keywords: food-related diseases; immunity; gut microbiota; functional foods; supplements

(This special issue belongs to the Section Clinical Nutrition)

Advances in Head and Neck Surgery: Precision Tools and Smart Technologies for Improved Surgical Outcomes

edited by

Stefano Settimi

and Claudio Parrilla

submission deadline 31 Jul 2026 | Viewed by 222 | Submission Open

Keywords: head and neck surgery; TORS; robotic surgery; transoral laser microsurgery; 3D-assisted surgical visualization; salivary gland surgery; new surgical techniques; animal models; endoscopic sinus surgery; skull base surgery; neuronavigation; nerve monitoring; nerve sparing; reconstructive surgery; 3D printing; augmented visualization; artificial intelligence

Mycobacterial Infections and Human Disease: Emerging Mechanisms and Therapeutic Strategies/Boundaries

edited by Sameer Tiwari, Ashutosh Tripathi and

Shahid Umar

submission deadline 1 Aug 2026 | 3 articles | Viewed by 4551 | Submission Open

Keywords: tuberculosis; pathogenesis; drug resistance; vaccine

(This special issue belongs to the Section Infectious Disease)

Microbiota in Human Disease

edited by

Rossella Cianci

and

Pierluigi Rio

submission deadline 31 Aug 2026 | 5 articles | Viewed by 49062 | Submission Open

Keywords: microbiota; immune system; adaptive and innate immunity; infectious diseases; non-communicable diseases

Research Progress in Neurodegenerative Diseases

edited by

Christian Barbato

submission deadline 31 Aug 2026 | 6 articles | Viewed by 33188 | Submission Open

Keywords: neurodegenerative diseases; neurobiology; Alzheimer's disease; Parkinson's disease; prion diseases; amyotrophic lateral sclerosis; NeuroCOVID-19; neuroimaging; microbiota gut-brain axis; RNA therapy

(This special issue belongs to the Section Neuro-psychiatric Disorders)

Research Topics in Thrombosis-Inducing Diseases

edited by

Robert Maitta

and Yi Yuan Zhou

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1680 | Submission Open

Keywords: thrombosis; thrombotic microangiopathy; TTP; HUS; heparin-induced thrombocytopenia; emboli; thrombi; deep vein thrombosis; clotting factor

Integrating Molecular Genetics and Network Pharmacology: In Silico Approaches to Target Rare Disorders and Complex Diseases Using Natural or Chemical Compounds

edited by

Vikas Yadav

and

Shakti Ranjan Satapathy

submission deadline 31 Aug 2026 | Viewed by 266 | Submission Open

Keywords: natural/chemical compounds; molecular docking; network pharmacology; protein– protein interaction; biomarker discovery; cancer; complex diseases; rare genetic disorders; in silico drug design; drug repositioning

(This special issue belongs to the Section Rare Syndrome)

Mental Health Across the Lifespan: Integrating Multidisciplinary Perspectives

edited by Boris G. Tilov,

Mariya Dimitrova

and

Amal Mitra

submission deadline 30 Sep 2026 | 7 articles | Viewed by 33168 | Submission Open

Keywords: mental health; lifespan perspective; multidisciplinary approaches; psychological resilience; cognitive health; preventive strategies; psychosocial interventions; healthcare innovations; oral health and mental health; physical activity and mental well-being

Gastric Cancer: New Trends in Endoscopic Diagnosis Staging and Treatment

edited by

Germana de Nucci

and Gianpiero Manes

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2505 | Submission Open

Keywords: gastric cancer; endoscopy; diagnosis; treatment

(This special issue belongs to the Section Oncology)

Viral Hepatitis: Diagnosis, Treatment and Management—2nd Edition

edited by Resat Ozaras,

Veysel Tahan

and Ebubekir Dağlılar

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2064 | Submission Open

Keywords: viral hepatitis; acute hepatitides (A; B; C; D; E); chronic hepatitides (B; C; D); HBV infection; HBV/HCV; HBV-HIV; HCV/HIV; cirrhosis; hepatocellular carcinoma; portal hypertension

Recent Advances in Gastroenterology and Nutrition (2nd Edition)

edited by

Vincent Ho

and

Jerry Zhou

submission deadline 1 Oct 2026 | 2 articles | Viewed by 1602 | Submission Open

Keywords: gut microbiome; metagenomics; proteomics; faecal metabolites; probiotics; prebiotics; postbiotics; faecal microbial transplantation

(This special issue belongs to the Section Gastroenterology)

From Monitoring to Management: Addressing Challenges in Type 1 and Type 2 Diabetes Care

edited by

Lucas Fornari Laurindo

and

Sandra Barbalho

submission deadline 31 Oct 2026 | 7 articles | Viewed by 15857 | Submission Open

Keywords: metabolism; metabolic diseases; medicinal plants; phytochemicals; bioactive compounds; metabolic diseases complications

Insights into the Management of Cardiovascular Disease Risk Factors

edited by

Paweł Muszyński

and Anna Tomaszuk-Kazberuk

submission deadline 31 Oct 2026 | 5 articles | Viewed by 12168 | Submission Open

Keywords: cardiovascular diseases; non-classical risk factors; residual risk; systemic inflammation

(This special issue belongs to the Section Cardiology)

Frailty and Frequent Hospitalizations in Older Adults: Risk, Management, and Interventions

edited by Francesco Ragusa and

Nicola Veronese

submission deadline 31 Oct 2026 | 3 articles | Viewed by 2522 | Submission Open

Keywords: frailty; hospital readmissions; aging; geriatric care; interventions; risk factors; transitional care; older adults; healthcare utilization; multimorbidity

The Future of Mental Health: Bridging the Translational Gap Between Mechanism, Practice, and Ethics

edited by

Anamaria Ciubara

and Pantelie Nicolcescu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 630 | Submission Open

Keywords: mental health; translational psychiatry; neuroinflammation; psychiatric genetics; artificial intelligence in mental healthcare; digital psychiatry; precision psychiatry; ethics in mental health; translational neuroscience

Gerontopsychiatry: Research, Perspectives, Innovation and Progress in Geriatric Psychiatry

edited by

Lavinia-Alexandra Moroianu

and Frédéric Bloch

submission deadline 31 Oct 2026 | Viewed by 264 | Submission Open

Keywords: gerontopsychiatry; aging; innovation; neurocognitive disorders; late-life depression; digital health; neuroinflammation; integrated care; resilience

(This special issue belongs to the Section Neuro-psychiatric Disorders)

Feature Papers in the 'Respiratory Diseases’ Section in 2026–2027

edited by

Gaetano Caramori

and

Andrea Bianco

submission deadline 1 Nov 2026 | Viewed by 325 | Submission Open

Keywords: COPD; persistent (chronic; fixed) airflow limitation; lung cancer; DLDs/ILDs; pneumonia; mycobacterial infections

(This special issue belongs to the Section Respiratory Diseases)

Metabolic Disorders: Insights into Pathogenesis and Novel Therapeutic Strategies (2nd Edition)

edited by

Nikolaos Theodorakis

and Maria Nikolaou

submission deadline 30 Nov 2026 | 1 articles | Viewed by 17902 | Submission Open

Keywords: metabolic disorders; cardio– renal– hepatic– metabolic syndrome; cardiometabolic medicine; obesity; diabetes mellitus

Mental Health—Management and Care, Multidisciplinary Approaches and Perspectives

edited by

Lavinia-Alexandra Moroianu

Oana Maria Isailă

, Cecilia Curis and

Cristina Bredicean

submission deadline 30 Nov 2026 | 10 articles | Viewed by 13452 | Submission Open

Keywords: prevention and early intervention; anticipating factors for anxiety and depression; ⁠personalised and precision mental healthcare; stigmatisation; artificial intelligence; mHealth; telepsychiatry and online therapy; ethical issues; psychosomatics

(This special issue belongs to the Section Neuro-psychiatric Disorders)

Dietary Effects on Health Status in South-East Asia Population

edited by

Ciro Gargiulo Isacco

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2590 | Submission Open

Keywords: cancer; cardiovascular diseases; diet; malnutrition; metabolic syndrome; type 2 diabetes

(This special issue belongs to the Section Clinical Nutrition)

The Role of Nutrition in the Management of Gastrointestinal Disorders

edited by

Hélio José Coelho-Júnior

submission deadline 30 Nov 2026 | Viewed by 140 | Submission Open

Keywords: nutrition; dietary patterns; nutritional behavior; gastrointestinal diseases; gastroesophageal reflux disease; inflammatory bowel disease; Crohn’ s disease; irritable bowel syndrome; celiac disease; diarrhea

(This special issue belongs to the Section Gastroenterology)

Towards Precision Treatment: Advances in the Diagnosis and Treatment of Heart Failure

edited by

Feola Mauro

and

Alberto Palazzuoli

submission deadline 30 Nov 2026 | Viewed by 92 | Submission Open

Keywords: heart failure; heart failure therapy; comorbidity in heart failure; prognostic assessment in heart failure; ambulatory care model

(This special issue belongs to the Section Cardiology)

‘Rare Syndromes: Diagnosis and Treatment’ in 2024–2026

edited by

Mojgan Rastegar

and

Jose Sanchez-Alcazar

submission deadline 31 Dec 2026 | 5 articles | Viewed by 9107 | Submission Open

Keywords: epidemiology; social aspects; pathogenic mechanisms; genetic aspects; prevention; diagnostic tools; artificial intelligence; patient care; clinical aspects; therapy; patient management; study of animal models; in vitro models

(This special issue belongs to the Section Rare Syndrome)

Diseases: From Molecular to the Clinical Perspectives

edited by

Omar Cauli

submission deadline 31 Dec 2026 | 8 articles | Viewed by 7720 | Submission Open

Keywords: cardiovascular diseases; gastrointestinal and urological diseases; endocrine diseases; nutritional diseases; infectious diseases; neurodegenerative diseases; chronic diseases; hereditary diseases; cancer; neuropsychiatric conditions and mental disorders; immunology; rare syndromes; pathology; therapy; and pathogenesis of human diseases; diseases and society; including patient care

Advances in Melanoma: From Basic Research to Clinical Management, and Future Horizons Exploitation

edited by

Laura Atzori

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2965 | Submission Open

Keywords: melanoma; epidemiology; gene expression profile; prognosis; target therapy; diagnosis; artificial intelligence

(This special issue belongs to the Section Oncology)

Advances in Molecular Pathogenesis, Precision Medicine, and Artificial Intelligence in Hematologic Malignancies

edited by

Eleftheria Hatzimichael

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1809 | Submission Open

Keywords: hematologic malignancies; molecular pathogenesis; precision medicine; personalized treatment; artificial intelligence; machine learning; targeted therapy; genomic profiling; biomarkers; translational research; digital pathology

(This special issue belongs to the Section Oncology)

Immune-Mediated Thrombosis: Mechanisms, Vaccine Association, and Therapeutic Innovations

edited by

Amrita Sarkar

submission deadline 31 Dec 2026 | Viewed by 226 | Submission Open

Keywords: immune-mediated thrombosis; VITT; vaccine safety; thrombotic complications; hematology; immunopathology; mrna vaccines; autoimmunity; thrombocytopenia; antibody-mediated clotting disorders

Molecular Biomarkers and Precision Medicine in Human Diseases: From Discovery to Clinical Application

edited by

Sandra Barbalho

and

Lucas Fornari Laurindo

submission deadline 31 Jan 2027 | Viewed by 28 | Submission Open

Keywords: molecular biomarkers; proteomics; precision medicine; multi-omics; cancer biomarkers; diagnostic biomarkers; prognostic biomarkers; liquid biopsy; translational medicine; therapeutic response

Primary Care Integration Strategies for Chronic Disease Management

edited by