Special Issue "Lateral Flow Immunoassays"

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Point-of-Care Diagnostics and Devices".

Deadline for manuscript submissions: closed (20 July 2020).

Special Issue Editor

Prof. Dr. María Carmen Blanco-López
Website
Guest Editor
Department of Physical and Analytical Chemistry, University of Oviedo, Julián Clavería 8, 33006 Oviedo, Spain
Interests: extracellular vesicles; biosensors and bioanalytics; nanomaterial sensors
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Lateral flow immunoassays are well known in their use as a platform for pregnancy tests. However, they have a wide scope of applications in medicine, toxicology, and pathogen detection. Lateral flow immunoassays are able to meet the actual demands on analytical systems in being decentralized, user-friendly, and low cost. Biomedical uses include the diagnostics and prognostics of several diseases, such as infections, tumors, cardiology, or neurological-related disorders and allergies. They also attract great interest in food science or environmental control for the detection of pathogens through toxins or their DNA.

In order to reach new fields of applications, some of the actual limitations include the need to couple quantification systems while maintaining the portability and simplicity of the test, and the need for amplification when conducting nucleic acid-based detection. Mobile phone applications using the optical density of test lines are already in the market, but for many uses, lower limits of detection are required. It is expected that nanomaterials with novel physicochemical properties will soon lead to the development of original solutions to overcome those obstacles.

This Special Issue aims to gather representative research papers and reviews on the progress of lateral flow immunoassays towards empowering citizens with the analysis control.

Dr. María Carmen Blanco-López
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lateral flow immunoassays
  • nanoparticles
  • amplification systems
  • biomarkers
  • allergens
  • pathogens
  • toxins
  • immunochromatographic tests

Published Papers (1 paper)

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Review

Open AccessReview
Magnetic Lateral Flow Immunoassays
Diagnostics 2020, 10(5), 288; https://doi.org/10.3390/diagnostics10050288 - 08 May 2020
Cited by 2
Abstract
A new generation of magnetic lateral flow immunoassays is emerging as powerful tool for diagnostics. They rely on the use of magnetic nanoparticles (MNP) as detecting label, replacing conventional gold or latex beads. MNPs can be sensed and quantified by means of external [...] Read more.
A new generation of magnetic lateral flow immunoassays is emerging as powerful tool for diagnostics. They rely on the use of magnetic nanoparticles (MNP) as detecting label, replacing conventional gold or latex beads. MNPs can be sensed and quantified by means of external devices, allowing the development of immunochromatographic tests with a quantitative capability. Moreover, they have an added advantage because they can be used for immunomagnetic separation (IMS), with improvements in selectivity and sensitivity. In this paper, we have reviewed the current knowledge on magnetic-lateral flow immunoassay (LFIA), coupled with both research and commercially available instruments. The work in the literature has been classified in two categories: optical and magnetic sensing. We have analysed the type of magnetic nanoparticles used in each case, their size, coating, crystal structure and the functional groups for their conjugation with biomolecules. We have also taken into account the analytical characteristics and the type of transduction. Magnetic LFIA have been used for the determination of biomarkers, pathogens, toxins, allergens and drugs. Nanocomposites have been developed as alternative to MNP with the purpose of sensitivity enhancement. Moreover, IMS in combination with other detection principles could also improve sensitivity and limit of detection. The critical analysis in this review could have an impact for the future development of magnetic LFIA in fields requiring both rapid separation and quantification. Full article
(This article belongs to the Special Issue Lateral Flow Immunoassays)
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