Special Issue "Advances in the Diagnostic Role of Microbiota in Human Diseases"

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Diagnostic Microbiology and Infectious Disease".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. Vincent Blasco-Baque
E-Mail Website
Guest Editor
Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France
Interests: metabolic diseases; diabetes; metabolism; insulin resistance; glucose metabolism; nutrition; fat; energy metabolism; inflammatory biomarkers; clinical nutrition; human microbiota

Special Issue Information

Dear Colleagues,

It has recently become evident that many factors play pivotal roles in the diagnosis and management of systemic health. The human microbiota is a super organ in our body. When the microbiota is disrupted, which is called dysbiosis, the occurrence of diseases is then increased and management becomes complex. Metabolic patients with dysbiotic microbiota are most at risk for cardiovascular disease. Moreover, dysbiosis of the microbiota is also involved in many systemic diseases, such as diabetes, obesity, autoimmune rheumatic disease, and cancer. In this Special Issue, we will address the nature of the human microbiota and how it affects systemic pathologies with bidirectional interactions. Exploration of the human microbiota may be a key factor, and its diagnostic may contribute to chronic metabolic diseases or human diseases. The role of human microbiota (oral, gut, skin) is the next evolution for biology and medicine. We are also interested in future therapeutic strategies. The discovery of the implications of microbiota for the control of systemic diseases could represent a new method for personalized medicine.

Dr. Vincent Blasco-Baque
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Open AccessArticle
Obesity Drives an Oral Microbiota Signature of Female Patients with Periodontitis: A Pilot Study
Diagnostics 2021, 11(5), 745; https://doi.org/10.3390/diagnostics11050745 - 21 Apr 2021
Viewed by 210
Abstract
The aim of this study was to analyze the link between oral microbiota and obesity in humans. We conducted a pilot study including 19 subjects with periodontitis divided into two groups: normo-weighted subjects (NWS) with a body mass index (BMI) between 20 and [...] Read more.
The aim of this study was to analyze the link between oral microbiota and obesity in humans. We conducted a pilot study including 19 subjects with periodontitis divided into two groups: normo-weighted subjects (NWS) with a body mass index (BMI) between 20 and 25 (n = 9) and obese subjects (OS) with a BMI > 30 (n = 10). Obesity was associated with a poor oral health status characterized by an increased number of missing teeth and a higher score of periodontal-support loss associated with dysbiotic oral microbiota (39.45 ± 3.74 vs. 26.41 ± 11.21, p = 0.03 for the Chao 1 index). Oral microbiota taxonomic analysis showed that the abundance of the Capnocytophaga genus was higher (2.47% ± 3.02 vs. 0.27% ± 0.29, p = 0.04) in OS compared to NWS. Obese females (OF) were characterized by an increase in the Streptococcus genus (34.12% ± 14.29 vs. 10.55% ± 10.42, p = 0.05) compared to obese males (OM), where the Neisseria genus was increased (5.75% ± 5.03 vs. 58.05% ± 30.64, p = 0.008). These first data suggest that sex/gender is determinant in the link between oral dysbiotic microbiota and obesity in patients with periodontitis. Our results could lead to recommendations concerning therapeutic strategies for obese patients with periodontitis following the sex/gender. Full article
(This article belongs to the Special Issue Advances in the Diagnostic Role of Microbiota in Human Diseases)
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