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Brief Report

Alteration in Nasopharyngeal Microbiota Profile in Aged Patients with COVID-19

1
Department of Pathology, Augusta University, Augusta, GA 30912, USA
2
Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA 30912, USA
3
Department of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada
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Department of Pathology, University of Notre Dame, Notre Dame, IN 46556, USA
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Department of Orthopedics, Augusta University, Augusta, GA 30912, USA
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Department of Pathology, Penn State University, State College, PA 16802, USA
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Department of Medicine, Augusta University, Augusta, GA 30912, USA
8
Center for Healthy Aging, Augusta University, Augusta, GA 30912, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Vincent Blasco-Baque and Rosa Del Campo
Diagnostics 2021, 11(9), 1622; https://doi.org/10.3390/diagnostics11091622
Received: 15 July 2021 / Revised: 26 August 2021 / Accepted: 30 August 2021 / Published: 5 September 2021
(This article belongs to the Special Issue Advances in the Diagnostic Role of Microbiota in Human Diseases)
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is an infectious virus that causes coronavirus disease 2019 (COVID-19) transmitted mainly through droplets and aerosol affecting the respiratory tract and lungs. Little is known regarding why some individuals are more susceptible than others and develop severe symptoms. In this study, we analyzed the nasopharyngeal microbiota profile of aged patients with COVID-19 (asymptomatic vs. symptomatic) vs. healthy individuals. We examined the nasopharynx swab of 84 aged-matched patients, out of which 27 were negative asymptomatic (NegA), 30 were positive asymptomatic (PA), and 27 patients were positive symptomatic (PSY). Our analysis revealed the presence of abundant Cyanobacterial taxa at phylum level in PA (p-value = 0.0016) and PSY (p-value = 0.00038) patients along with an upward trend in the population of Litoricola, Amylibacter, Balneola, and Aeromonas at the genus level. Furthermore, to know the relationship between the nasal microbiota composition and severity of COVID-19, we compared PA and PSY groups. Our data show that the nasal microbiota of PSY patients was significantly enriched with the signatures of two bacterial taxa: Cutibacterium (p-value = 0.045) and Lentimonas (p-value = 0.007). Furthermore, we also found a significantly lower abundance of five bacterial taxa, namely: Prevotellaceae (p-value = 7 × 10−6), Luminiphilus (p-value = 0.027), Flectobacillus (p-value = 0.027), Comamonas (p-value = 0.048), and Jannaschia (p-value = 0.012) in PSY patients. The dysbiosis of the nasal microbiota in COVID-19 positive patients might have a role in contributing to the severity of COVID-19. The findings of our study show that there is a strong correlation between the composition of the nasal microbiota and COVID-19 severity. Further studies are needed to validate our finding in large-scale samples and to correlate immune response (cytokine Strome) and nasal microbiota to identify underlying mechanisms and develop therapeutic strategies against COVID-19. View Full-Text
Keywords: microbiota; nasopharyngeal profile in aged patients with COVID-19 infection and severity microbiota; nasopharyngeal profile in aged patients with COVID-19 infection and severity
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MDPI and ACS Style

Kolhe, R.; Sahajpal, N.S.; Vyavahare, S.; Dhanani, A.S.; Adusumilli, S.; Ananth, S.; Mondal, A.K.; Patterson, G.T.; Kumar, S.; Rojiani, A.M.; Isales, C.M.; Fulzele, S. Alteration in Nasopharyngeal Microbiota Profile in Aged Patients with COVID-19. Diagnostics 2021, 11, 1622. https://doi.org/10.3390/diagnostics11091622

AMA Style

Kolhe R, Sahajpal NS, Vyavahare S, Dhanani AS, Adusumilli S, Ananth S, Mondal AK, Patterson GT, Kumar S, Rojiani AM, Isales CM, Fulzele S. Alteration in Nasopharyngeal Microbiota Profile in Aged Patients with COVID-19. Diagnostics. 2021; 11(9):1622. https://doi.org/10.3390/diagnostics11091622

Chicago/Turabian Style

Kolhe, Ravindra, Nikhil Shri Sahajpal, Sagar Vyavahare, Akhilesh S. Dhanani, Satish Adusumilli, Sudha Ananth, Ashis K. Mondal, G. Taylor Patterson, Sandeep Kumar, Amyn M. Rojiani, Carlos M. Isales, and Sadanand Fulzele. 2021. "Alteration in Nasopharyngeal Microbiota Profile in Aged Patients with COVID-19" Diagnostics 11, no. 9: 1622. https://doi.org/10.3390/diagnostics11091622

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