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Progress in Oral Microbiome Related to Oral and Systemic Diseases: An Update

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Department of Orofacial Pain and Oral Medicine, Kyung Hee University Dental Hospital, #613 Hoegi-dong, Dongdaemun-gu, Seoul 02447, Korea
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Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea
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Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea
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Department of Biomedical Engineering, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea
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Department of Pharmacology, School of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea
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Department of Periodontology, Periodontal-Implant Clinical Research Institute, School of Dentistry, Kyung Hee University, Dongdaemun-gu, Seoul 02447, Korea
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Authors to whom correspondence should be addressed.
Academic Editor: Vincent Blasco-Baque
Diagnostics 2021, 11(7), 1283; https://doi.org/10.3390/diagnostics11071283
Received: 21 June 2021 / Revised: 9 July 2021 / Accepted: 14 July 2021 / Published: 16 July 2021
(This article belongs to the Special Issue Advances in the Diagnostic Role of Microbiota in Human Diseases)
The human oral microbiome refers to an ecological community of symbiotic and pathogenic microorganisms found in the oral cavity. The oral cavity is an environment that provides various biological niches, such as the teeth, tongue, and oral mucosa. The oral cavity is the gateway between the external environment and the human body, maintaining oral homeostasis, protecting the mouth, and preventing disease. On the flip side, the oral microbiome also plays an important role in the triggering, development, and progression of oral and systemic diseases. In recent years, disease diagnosis through the analysis of the human oral microbiome has been realized with the recent development of innovative detection technology and is overwhelmingly promising compared to the previous era. It has been found that patients with oral and systemic diseases have variations in their oral microbiome compared to normal subjects. This narrative review provides insight into the pathophysiological role that the oral microbiome plays in influencing oral and systemic diseases and furthers the knowledge related to the oral microbiome produced over the past 30 years. A wide range of updates were provided with the latest knowledge of the oral microbiome to help researchers and clinicians in both academic and clinical aspects. The microbial community information can be utilized in non-invasive diagnosis and can help to develop a new paradigm in precision medicine, which will benefit human health in the era of post-metagenomics. View Full-Text
Keywords: oral microbiome; oral cavity; dysbiosis; oral diseases; systemic diseases oral microbiome; oral cavity; dysbiosis; oral diseases; systemic diseases
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MDPI and ACS Style

Lee, Y.-H.; Chung, S.W.; Auh, Q.-S.; Hong, S.-J.; Lee, Y.-A.; Jung, J.; Lee, G.-J.; Park, H.J.; Shin, S.-I.; Hong, J.-Y. Progress in Oral Microbiome Related to Oral and Systemic Diseases: An Update. Diagnostics 2021, 11, 1283. https://doi.org/10.3390/diagnostics11071283

AMA Style

Lee Y-H, Chung SW, Auh Q-S, Hong S-J, Lee Y-A, Jung J, Lee G-J, Park HJ, Shin S-I, Hong J-Y. Progress in Oral Microbiome Related to Oral and Systemic Diseases: An Update. Diagnostics. 2021; 11(7):1283. https://doi.org/10.3390/diagnostics11071283

Chicago/Turabian Style

Lee, Yeon-Hee, Sang W. Chung, Q-Schick Auh, Seung-Jae Hong, Yeon-Ah Lee, Junho Jung, Gi-Ja Lee, Hae J. Park, Seung-Il Shin, and Ji-Youn Hong. 2021. "Progress in Oral Microbiome Related to Oral and Systemic Diseases: An Update" Diagnostics 11, no. 7: 1283. https://doi.org/10.3390/diagnostics11071283

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