Advances in Thrombosis Diagnosis and Antithrombotic Therapy

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 902

Special Issue Editors


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Guest Editor
Division of Cardiology, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, 10126 Turin, Italy
Interests: acute coronary syndromes; thrombosis; cardiovascular prevention; percutaneous coronary intervention
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Guest Editor
1. Department of Medical Science, University of Turin, Turin, Italy
2. Division of Cardiology, Città della Salute e della Scienza Hospital, Turin, Italy
Interests: coronary artery disease; cardiac CT; acute coronary syndrome
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Division of Cardiology, South Padova General Hospitals, 35043 Monselice, PD, Italy
Interests: ischemic heart disease; risk stratification; personalized medicine; dual antiplatelet therapy; bleeding risk; coronary artery disease

Special Issue Information

Dear Colleagues,

This Special Issue will focus on the evolving landscape of thrombosis diagnosis and antithrombotic therapy, with a particular emphasis on acute coronary syndromes, high-risk cardiovascular settings, and patients with complex comorbidities. Recent progress in diagnostic tools, including biomarkers, advanced imaging, and artificial intelligence, has enabled a more precise stratification of thrombotic risk and treatment needs. This issue welcomes original research, reviews, and perspectives on emerging pharmacological strategies, individualized therapeutic approaches, and future directions in integrating diagnostics and therapy in thrombosis care.

You may choose our Joint Special Issue in the Journal of Cardiovascular Development and Disease.

Dr. Ovidio De Filippo
Dr. Fabrizio D’Ascenzo
Guest Editors

Dr. Francesco Antonio Veneziano
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antithrombotic therapy
  • ischemic heart disease
  • risk stratification
  • personalized medicine
  • dual antiplatelet therapy
  • bleeding risk
  • coronary artery disease
  • artificial intelligence

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Published Papers (1 paper)

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Research

14 pages, 920 KB  
Article
Hypercoagulability in Light Chain Amyloidosis and the Importance of Predictive Value of TEG and TGT for Thrombosis Recurrence in Inflammatory States
by Mihai Emanuel Himcinschi, Mihaela Uta, Andreea Jercan, Daniel Murariu, Delia Codruta Popa, Valentina Uscatescu, Andrei Anghel, Daniel Coriu and Sorina Nicoleta Badelita
Diagnostics 2026, 16(7), 987; https://doi.org/10.3390/diagnostics16070987 - 25 Mar 2026
Viewed by 513
Abstract
Background: Thrombosis in light chain amyloidosis (LCA) occurs in the context of multiple organ dysfunction and inflammation. Conventional coagulation tests (screening) may not sufficiently capture the procoagulant substrate in the inflammatory/therapeutic dynamics. Methods: A total of 61 consecutive patients with LCA [...] Read more.
Background: Thrombosis in light chain amyloidosis (LCA) occurs in the context of multiple organ dysfunction and inflammation. Conventional coagulation tests (screening) may not sufficiently capture the procoagulant substrate in the inflammatory/therapeutic dynamics. Methods: A total of 61 consecutive patients with LCA were prospectively included in the study. Clinical data, including organ involvement, time of diagnosis, treatment phase, DOAC exposure and thrombosis history were systematically recorded and subjected to screening. Specialized hemostasis tests such as APTT/PT, fibrinogen, D-dimer, TEG and TGT were performed and conventional times were analyzed in the subgroup without DOAC. Results: The prevalence of documented thrombosis was 32.8%, and thrombosis status was associated with TEG positivity and more strongly with TGT positivity. Hypercoagulability was identified in 50.8% by TEG and 41.0% by TGT, regardless of whether APTT/PT were within the reference values. APTT/PT did not predict thrombosis recurrence (p > 0.05), which was predicted by TEG (p = 0.0027) and TGT (p = 0.0006). An inflammation/fibrin turnover panel (CRP, fibrinogen, D-dimer) predicted TEG positivity (p < 0.0001), but not TGT, and was correlated with assessment at diagnosis, daratumumab-based therapy, and cardiac involvement. Conclusions: Global tests (TEG/TGT) promptly correlate with thrombosis recurrence in our cohort and provide crucial information in addition to clotting times for thrombotic phenotyping. Inflammation can influence TEG, so the decision to recommend the tests and the timing of their performance should be adapted to the clinical, biological, and therapeutic context. Full article
(This article belongs to the Special Issue Advances in Thrombosis Diagnosis and Antithrombotic Therapy)
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