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Advances in Thrombosis Diagnosis and Antithrombotic Therapy
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Advances in Thrombosis Diagnosis and Antithrombotic Therapy

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425).

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1248

Special Issue Editors

Dr. Ovidio De Filippo

E-Mail Website
Guest Editor
Division of Cardiology, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, 10126 Turin, Italy
Interests: acute coronary syndromes; thrombosis; cardiovascular prevention; percutaneous coronary intervention
Special Issues, Collections and Topics in MDPI journals
Dr. Fabrizio D’Ascenzo

E-Mail Website
Guest Editor
1. Department of Medical Science, University of Turin, Turin, Italy
2. Division of Cardiology, Città della Salute e della Scienza Hospital, Turin, Italy
Interests: coronary artery disease; cardiac CT; acute coronary syndrome
Special Issues, Collections and Topics in MDPI journals
Dr. Francesco Antonio Veneziano

E-Mail Website
Guest Editor Assistant
Division of Cardiology, South Padova General Hospitals, 35043 Monselice, PD, Italy
Interests: ischemic heart disease; risk stratification; personalized medicine; dual antiplatelet therapy; bleeding risk; coronary artery disease

Special Issue Information

Dear Colleagues,

This Special Issue will focus on the evolving landscape of thrombosis diagnosis and antithrombotic therapy, with a particular emphasis on acute coronary syndromes, high-risk cardiovascular settings, and patients with complex comorbidities. Recent progress in diagnostic tools, including biomarkers, advanced imaging, and artificial intelligence, has enabled a more precise stratification of thrombotic risk and treatment needs. This issue welcomes original research, reviews, and perspectives on emerging pharmacological strategies, individualized therapeutic approaches, and future directions in integrating diagnostics and therapy in thrombosis care.

You may choose our Joint Special Issue in Diagnostics.

Dr. Ovidio De Filippo
Dr. Fabrizio D’Ascenzo
Guest Editors

Dr. Francesco Antonio Veneziano
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antithrombotic therapy
  • ischemic heart disease
  • risk stratification
  • personalized medicine
  • dual antiplatelet therapy
  • bleeding risk
  • coronary artery disease
  • artificial intelligence

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

20 pages, 8243 KB  
Review
Advances in the Diagnosis and Management of High-Risk Cardiovascular Conditions: Biomarkers, Intracoronary Imaging, Artificial Intelligence, and Novel Anticoagulants
by Clarissa Campo Dall’Orto, Rubens Pierry Ferreira Lopes, Gilvan Vilella Pinto, Filho, Pedro Gabriel Senger Braga and Marcos Raphael da Silva
J. Cardiovasc. Dev. Dis. 2026, 13(1), 52; https://doi.org/10.3390/jcdd13010052 - 19 Jan 2026
Viewed by 854
Abstract
Understanding thrombosis in acute coronary syndromes (ACSs) has evolved through advances in biomarkers, intracoronary imaging, and emerging analytical tools, improving diagnostic accuracy and risk stratification in high-risk patients. This narrative review provides an integrative overview of contemporary evidence from clinical trials, meta-analyses, and [...] Read more.
Understanding thrombosis in acute coronary syndromes (ACSs) has evolved through advances in biomarkers, intracoronary imaging, and emerging analytical tools, improving diagnostic accuracy and risk stratification in high-risk patients. This narrative review provides an integrative overview of contemporary evidence from clinical trials, meta-analyses, and international guidelines addressing circulating biomarkers, intracoronary imaging modalities—including optical coherence tomography (OCT), intravascular ultrasound (IVUS), and near-infrared spectroscopy (NIRS)—artificial intelligence–based analytical approaches, and emerging antithrombotic therapies. High-sensitivity cardiac troponins and natriuretic peptides remain the most robust and guideline-supported biomarkers for diagnosis and prognostic assessment in ACS, whereas inflammatory markers and multimarker strategies offer incremental prognostic information but lack definitive validation for routine therapeutic guidance. Intracoronary imaging with IVUS or OCT is supported by current guidelines to guide percutaneous coronary intervention in selected patients with ACS and complex coronary lesions, leading to improved procedural optimization and clinical outcomes compared with angiography-guided strategies. Beyond procedural guidance, OCT enables detailed plaque characterization and mechanistic insights into ACS, while NIRS provides complementary information on lipid-rich plaque burden, primarily for risk stratification based on observational evidence. Artificial intelligence represents a rapidly evolving tool for integrating clinical, laboratory, and imaging data, with promising results in retrospective and observational studies; however, its clinical application in thrombosis management remains investigational due to the lack of outcome-driven randomized trials. In the therapeutic domain, factor XI inhibitors have demonstrated favorable safety profiles with reduced bleeding and preserved antithrombotic efficacy in phase II and early phase III studies, but their definitive role in ACS management awaits confirmation in large, outcome-driven randomized trials. Overall, the integration of biomarkers, intracoronary imaging, and emerging analytical and pharmacological strategies highlights the potential for more individualized cardiovascular care. Nevertheless, careful interpretation of existing evidence, rigorous validation, and alignment with guideline-directed practice remain essential before widespread clinical adoption. Full article
(This article belongs to the Special Issue Advances in Thrombosis Diagnosis and Antithrombotic Therapy)
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