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Diagnostics
Special Issues
Diagnostics and Management of Sarcopenia, Frailty, and Aging
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Diagnostics and Management of Sarcopenia, Frailty, and Aging

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1911

Editor

Dr. Jong Geol Do

E-Mail Website
Guest Editor
Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea
Interests: musculoskeletal diseases; electrodiagnostic medicine; spinal cord injury; intensive care unit rehabilitation; respiratory rehabilitation; sarcopenia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sarcopenia, frailty, and age-related functional decline represent interconnected syndromes that significantly impact the health and quality of life of older adults worldwide. This Special Issue of Diagnostics will provide a comprehensive overview of recent advances in the diagnosis, assessment, and management of these conditions. We welcome original research, systematic reviews, and clinical studies that address novel diagnostic approaches, including the identification and validation of predictive biomarkers, advanced imaging modalities, and digital health-based assessment tools. Additionally, this Special Issue will explore the complex interplay between sarcopenia and frailty, examining shared pathophysiological mechanisms and clinical implications. Therapeutic strategies encompassing pharmacological interventions, exercise-based rehabilitation, nutritional optimization, and emerging technologies such as wearable devices and artificial intelligence-driven monitoring systems are of particular interest. We also encourage submissions investigating the role of multidisciplinary care models in preventing and managing muscle loss and functional decline in aging populations. This Special Issue will serve as a valuable resource for clinicians, researchers, and healthcare professionals seeking evidence-based strategies to address the growing burden of sarcopenia and frailty.

Dr. Jong Geol Do
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sarcopenia
  • frailty
  • aging
  • geriatric
  • rehabilitation
  • biomarkers
  • digital health

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Published Papers (1 paper)

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Review

27 pages, 1441 KB  
Review
Defining Sarcopenia in Oncology by CT-Based Muscle Mass: The Clinical and Research Consequences of a Diagnostic Surrogate
by Erkan Topkan, Efsun Somay, Duriye Ozturk and Ugur Selek
Diagnostics 2026, 16(11), 1611; https://doi.org/10.3390/diagnostics16111611 - 25 May 2026
Viewed by 722
Abstract
Sarcopenia is increasingly invoked as a determinant of treatment-related toxicity, perioperative morbidity, treatment intolerance, and survival in oncology; however, contemporary international consensus frameworks define sarcopenia as a multidimensional neuromuscular syndrome centered on impaired muscle strength, physical performance, and muscle quality, whereas most oncologic [...] Read more.
Sarcopenia is increasingly invoked as a determinant of treatment-related toxicity, perioperative morbidity, treatment intolerance, and survival in oncology; however, contemporary international consensus frameworks define sarcopenia as a multidimensional neuromuscular syndrome centered on impaired muscle strength, physical performance, and muscle quality, whereas most oncologic studies operationalize sarcopenia using computed tomography (CT)-derived skeletal muscle mass alone. In this context, muscle quantity is effectively employed as a diagnostic surrogate for a function-centered syndrome. CT-defined skeletal muscle depletion—more precisely described as myopenia—remains a reproducible and clinically informative structural biomarker, yet defining sarcopenia by muscle mass alone aggregates biologically heterogeneous phenotypes, including neuromuscular dysfunction, inflammation-driven cachexia, and substrate-related malnutrition. Such surrogate-based definitions contribute to variable prevalence estimates, inconsistent prognostic associations, and interpretive instability across studies. Clinically, reliance on CT-based muscle mass as a surrogate for sarcopenia may influence chemotherapy dosing, perioperative risk stratification, and supportive care allocation without direct assessment of neuromuscular function; in research settings, mass-based definitions may dilute treatment effects in exercise or nutritional trials and complicate meta-analytic synthesis by conflating structural and functional constructs. This analysis does not question the value of radiologic muscle assessment but argues that CT-derived muscle mass should be recognized as a structural biomarker within a multidimensional framework rather than as a standalone diagnostic surrogate for sarcopenia. A tiered, oncology-adapted approach integrating functional assessment, muscle quality, and relevant metabolic context may enhance risk discrimination, improve trial design, and strengthen translational precision in supportive oncology. Full article
(This article belongs to the Special Issue Diagnostics and Management of Sarcopenia, Frailty, and Aging)
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