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Diagnostics
Special Issues
Precision Strategies to Improve Diagnosis and Prognosis in Gastrointestinal Disease
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Precision Strategies to Improve Diagnosis and Prognosis in Gastrointestinal Disease

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 5270

Special Issue Editors

Dr. Manuel Barberio

E-Mail Website
Guest Editor
1. Institute for Research against Digestive Cancer (IRCAD), 67091 Strasbourg, France
2. Department of General Surgery, Hospital Card. G. Panico, 73039 Tricase, Italy
Interests: optical imaging; image-guided surgery; surgical innovation; robotic surgery; machine learning and hyperspectral imaging
Special Issues, Collections and Topics in MDPI journals
Dr. Deborah S. Keller

E-Mail Website
Guest Editor
Department of Surgery, Division of Colorectal Surgery, Lankenau Medical Center, Wynnewood, PA, USA
Interests: surgical innovation; imaging biomarkers; developing standards for colorectal cancer delivery
Dr. Massimo Giuseppe Viola

E-Mail Website
Guest Editor
Department of General Surgery, Hospital Card. G. Panico, 73039 Tricase, Italy
Interests: hepatobiliopancreatic surgery; colorectal surgery; upper-GI surgery; oncological surgery; gastrointestinal surgery; ERAS protocol; minimally invasive surgery; robotic surgery; optical imaging; fluorescence-guided imaging; hyperspectral imaging
Dr. Mahdi Al-Taher

E-Mail Website
Guest Editor
1. Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
2. Research Institute against Digestive Cancer (IRCAD), Strasbourg, France
Interests: optical imaging; image-guided surgery; surgical innovation; robotic surgery; machine learning and hyperspectral imaging; colorectal surgery
Dr. Filippo Carannante

E-Mail Website
Guest Editor
Unit of Colorectal Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200-00128 Roma, Italy
Interests: abdominal surgery; minimally invasive surgery; colorectal surgery; colorectal cancer; IBD; image-guided surgery; rectal functional disorders; ERAS
Special Issues, Collections and Topics in MDPI journals
Dr. Marco Caricato

E-Mail Website
Guest Editor
Unit of Colorectal Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 00128 Roma, Italy
Interests: abdominal surgery; minimally invasive surgery; colorectal surgery; colorectal cancer; IBD; image-guided surgery; rectal functional disorders; ERAS

Special Issue Information

Dear Colleagues,

The diagnosis and prognosis of gastrointestinal disease have undergone major advances over the last 25 years, with enhancements in chemotherapeutic agents, patient optimization strategies, novel operative techniques and minimally invasive surgery platforms. These changes have led to dramatic improvements in oncologic and functional outcomes, as well as in the quality of life of patients. Despite these advances, there remains a need to increase the accuracy and precision of the diagnosis and prognosis of gastrointestinal disease, especially in gastrointestinal cancer cases. The integration of innovative technologies during preoperative staging and in the operating room during procedures addresses these needs. Robust preclinical research is ongoing to help determine the most sensitive and specific biomarkers to distinguish malignant disease from normal surrounding tissue. Also of note is the clinical application of innovative image-guided surgery techniques, which permits the development of predictive algorithms and real-time advanced vision in the operating room. These exciting new technologies may translate to safer and more efficient surgical planning, surgical procedures, and patient outcomes. In this Special Issue, we present original work on the novel preclinical and clinical technologies, operative techniques, and perioperative management strategies that are being developed and applied to increase precision diagnosis and prognosis in gastrointestinal cases. Introducing the current state and future goals for these new tools from experts in the field will provide readers with an understanding of those innovative tools, their application, and their potential in gastrointestinal surgery.

Dr. Manuel Barberio
Dr. Deborah S. Keller
Dr. Massimo Giuseppe Viola
Dr. Mahdi Al-Taher
Dr. Filippo Carannante
Dr. Marco Caricato
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnosis and prognosis
  • gastrointestinal disease
  • robotic surgery
  • new technologies
  • image-guided fluorescence
  • surgical innovation
  • precision surgery

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Published Papers (3 papers)

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Research

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13 pages, 4631 KiB  
Article
Retrocolic Fascia—An Anatomical and Multidetector Computed Tomographic Angiography (MDCTA) Morphometric Analysis in Patients with Right Colon Cancer
by Antoine Chemtob, Dejan Ignjatovic and Bojan V. Stimec
Diagnostics 2024, 14(17), 1952; https://doi.org/10.3390/diagnostics14171952 - 3 Sep 2024
Cited by 1 | Viewed by 1153
Abstract
Background: This study aims to delineate anatomical landmarks crucial for complete mesocolic excision, focusing on Gerota’s fascia, which guides surgical dissection in right-sided colon cancer, forming the posterior limit. Employing a multimodal approach, the research aims to understand the fascial anatomy and its [...] Read more.
Background: This study aims to delineate anatomical landmarks crucial for complete mesocolic excision, focusing on Gerota’s fascia, which guides surgical dissection in right-sided colon cancer, forming the posterior limit. Employing a multimodal approach, the research aims to understand the fascial anatomy and its variations under pathological conditions. Methods: Three methods were applied: a pilot dissection on an embalmed cadaver for clear anatomical presentation of prerenal fascia, Mimics segmentation of the fascia and its relationship with the colon, and a retrospective analysis of MDCTA scans from 196 patients (mean age 65.73 y, 118 F/78 M). Systematic measurements of fascial thickness were taken at key renal levels—upper pole, hilum, lower pole, and infra-renal. Covariates analyzed included Body Mass Index, age, and sex. Results: The pilot dissection revealed the renal fascia of Gerota as the only true retrocolic compact connective tissue and the fusion fascia of Toldt as a mesh of strands of loose connective tissue and fat lobules. MDCTA showed clearer visualization of Gerota’s fascia at the hilum and inferior renal pole, predominantly on the left. There were significant differences in fascial thickness between sides (1.30 mm on the right and 1.34 mm on the left) and a positive correlation with BMI, whereas age and sex showed no significant effects. Conclusion: Gerota’s fascia is a critical anatomical landmark in CME for right colon cancer. This study highlights the fascia’s structural integrity, unaffected by the tumor, underscoring its importance in surgical navigation. Full article
(This article belongs to the Special Issue Precision Strategies to Improve Diagnosis and Prognosis in Gastrointestinal Disease)
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16 pages, 2520 KiB  
Article
Analysis of Predictors and Risk Factors of Postpolypectomy Syndrome
by Stefano Fusco, Michelle E. Bauer, Ulrike Schempf, Dietmar Stüker, Gunnar Blumenstock, Nisar P. Malek, Christoph R. Werner and Dörte Wichmann
Diagnostics 2024, 14(2), 127; https://doi.org/10.3390/diagnostics14020127 - 5 Jan 2024
Cited by 1 | Viewed by 2224
Abstract
Background and aims: Postpolypectomy syndrome (PPS) is a relevant adverse event that can appear after polypectomy. Several publications mention postpolypectomy syndrome using different criteria to define it. The aim of this study is to detect potential risk factors and predictors for developing PPS [...] Read more.
Background and aims: Postpolypectomy syndrome (PPS) is a relevant adverse event that can appear after polypectomy. Several publications mention postpolypectomy syndrome using different criteria to define it. The aim of this study is to detect potential risk factors and predictors for developing PPS and to define the main criteria of PPS. Methods: In this retrospective monocentric study, 475 out of 966 patients who underwent colonoscopy with polypectomy from October 2015 to June 2020 were included. The main criterion of PPS is defined as the development of postinterventional abdominal pain lasting more than six hours. Results: A total of 9.7% of the patients developed PPS, which was defined as local abdominal pain around the polypectomy area after six hours. A total of 8.6% of the study population had abdominal pain within six hours postintervention. A total of 3.7% had an isolated triad of fever, leukocytosis, and increased CRP in the absence of abdominal pain. Increased CRP combined with an elevated temperature over 37.5 °C seems to be a positive predictor for developing PPS. Four independent risk factors could be detected: serrated polyp morphology, polypoid configurated adenomas, polyp localization in the cecum, and the absence of intraepithelial neoplasia. Conclusions: Four independent risk factors for developing PPS were detected. The combination of increased CRP levels with elevated temperature seems to be a predictor for this pathology. As expected, the increasing use of cold snare polypectomies will reduce the incidence of this syndrome. Key summary: Our monocentric study on 966 patients detected four independent risk factors for developing PPS: pedunculated polyp, resected polyps in the cecum, absence of IEN, and serrated polyp morphology. The combination of increased CRP levels with elevated temperature seems to be a predictor for this pathology. Full article
(This article belongs to the Special Issue Precision Strategies to Improve Diagnosis and Prognosis in Gastrointestinal Disease)
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Other

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5 pages, 1525 KiB  
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Myeloid Sarcoma of the Colon Initially Presenting as a Paracolic Abscess in a Patient with Relapsed Acute Myeloid Leukemia
by Seo Yeon Youn, Yu Ri Shin and Gyeongsin Park
Diagnostics 2024, 14(11), 1062; https://doi.org/10.3390/diagnostics14111062 - 21 May 2024
Cited by 1 | Viewed by 1258
Abstract
Myeloid sarcoma, a rare extramedullary manifestation of acute myeloid leukemia (AML), can occur in various anatomic sites but seldom involves the gastrointestinal tract. We report the unusual case of a 49-year-old man with a history of AML who initially presented with abdominal pain [...] Read more.
Myeloid sarcoma, a rare extramedullary manifestation of acute myeloid leukemia (AML), can occur in various anatomic sites but seldom involves the gastrointestinal tract. We report the unusual case of a 49-year-old man with a history of AML who initially presented with abdominal pain and imaging findings suggestive of a paracolic abscess. However, the lesion rapidly progressed to a large descending colon mass with peritoneal involvement over five weeks. Surgical resection and histopathological examination confirmed a diagnosis of myeloid sarcoma. This case highlights the potential of myeloid sarcoma to mimic an inflammatory colonic process at initial presentation prior to manifesting as an overt mass lesion. Although exceedingly rare, myeloid sarcoma should be considered in patients with a history of AML presenting with colon lesions, particularly in those with an aggressive clinical course. Early recognition may expedite appropriate treatment and prevent unnecessary procedures. This report also underscores the importance of correlating imaging findings with clinical history and histopathology findings to establish an accurate diagnosis. Full article
(This article belongs to the Special Issue Precision Strategies to Improve Diagnosis and Prognosis in Gastrointestinal Disease)
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