Microbial Infections and Critical Care Medicine: Diagnosis and Management, 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Diagnostic Microbiology and Infectious Disease".

Deadline for manuscript submissions: 31 March 2027 | Viewed by 2634

Editors


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Guest Editor
Department of Adult Intensive Care Unit, Hippokratio General Hospital, Thessaloniki, Greece
Interests: anestesiology; mechanical ventilation; infectious disease; especially infections of multidrug-resistant bacteria in ICU patients and transplant recipients
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Guest Editor
Adult ICU, General Hospital of Thessaloniki “Ippokrateio”, 54642 Thessaloniki, Greece
Interests: ICU; lung diseases; hemodynamic monitoring; mechanical ventilation; respiratory medicine (i.e., COPD, Asthma, etc.); intensive care medicine (i.e., mechanical ventilation, hemodynamic monitoring, etc.); sleep medicine (i.e., OSAHS, parasomnias, etc.)
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Critical Care Department, Hippokration Hospital Thessaloniki, 54942 Thessaloniki, Greece
Interests: infectious disease; especially infectious of multidrugresistant bacteria in icu patients and transplant recipients
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to participate in this Special Issue of “Diagnostics” entitled “Microbial Infections and Critical Care Medicine: Diagnosis and Management, 2nd Edition”. According to WHO, microbial infections are categorized among the top 10 causes of death worldwide, irrespective of countries’ income group, while it is estimated that, by 2050, up to 10 million deaths could be caused by superbugs and associated forms of antimicrobial resistance, which are mainly found in critical care patients, making them the leading cause of death worldwide.

This Special Issue aims to draw attention to this evolving threat by investigating both the existing and upcoming tools that physicians will have available in their arsenal in order to rigorously diagnose and successfully manage this threat.

In this Special Issue, original research articles and reviews are welcome. Important, novel, and interesting short communications or case report studies will also be considered. Research areas will mainly include (but not be limited to) the diagnosis and management of microbial infections in critical care medicine.

We look forward to receiving your contributions.

Dr. Eleni K. Mouloudi
Dr. Serafeim Chrysovalantis Kotoulas
Dr. Eleni Massa 
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbial infections
  • superbugs
  • antimicrobial resistance
  • multi-drug resistance
  • critical care
  • diagnosis
  • management

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Published Papers (1 paper)

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Research

12 pages, 507 KB  
Article
Invasive Fungal Infections During Extracorporeal Membrane Oxygenation: A Case Series from Intensive Care Unit and Literature Review
by Francesca Serapide, Riccardo Serraino, Angelo Feola, Helen Linda Morrone, Vincenzo Olivadese, Giuseppe Neri, Eugenio Biamonte, Andrea Bruni, Eugenio Garofalo, Federico Longhini and Alessandro Russo
Diagnostics 2026, 16(4), 505; https://doi.org/10.3390/diagnostics16040505 - 7 Feb 2026
Cited by 2 | Viewed by 880
Abstract
Background: Extracorporeal membrane oxygenation (ECMO) support is associated with potentially life-threatening complications, among which nosocomial infections play a significant role. The increasing incidence of fungi as causative agents of ECMO-associated infections is a growing concern. Methods: This case series includes all [...] Read more.
Background: Extracorporeal membrane oxygenation (ECMO) support is associated with potentially life-threatening complications, among which nosocomial infections play a significant role. The increasing incidence of fungi as causative agents of ECMO-associated infections is a growing concern. Methods: This case series includes all patients admitted to the Intensive Care Unit (ICU) of the “Renato Dulbecco” Teaching Hospital in Catanzaro who developed invasive fungal infections (IFIs) during ECMO support. Results: Of the 70 patients, 15.7% (N = 11) developed IFIs during ECMO. Among these, 91% (N = 10) died, while one patient survived and was discharged. Of the IFIs, 72.7% (N = 8) were cases of invasive candidiasis (IC), and 18.2% (N = 2) were cases of invasive pulmonary aspergillosis (IPA). One patient developed both IC and IPA during ECMO treatment. Additionally, 54.5% (N = 6) of the patients with IFIs also had bacterial co-infections, most of which were caused by multidrug-resistant (MDR) Gram-negative bacteria. Conclusions: This study highlights the high incidence and mortality of IFIs in ECMO patients. It underscores the urgent need for clear definitions, better diagnostic strategies, pharmacokinetic data on antifungal therapies, and the implementation of therapeutic drug monitoring (TDM) to optimize outcomes in this vulnerable population. Full article
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