Surgical and Medical Management of Pancreatic Tumors: Indication, Techniques, and Prognostic Factors

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Surgical Oncology".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 340

Special Issue Editors


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Guest Editor
1. Department of Medicine and Surgery, LUM University, Casamassima, 70010 Bari, Italy
2. Unit of Hepato-Biliary and Pancreatic Surgery, “F. Miulli” General Hospital, Acquaviva delle Fonti, 70021 Bari, Italy
Interests: HPB surgery; minimally invasive and robotic surgery

E-Mail Website
Guest Editor
Unit of Hepato-Biliary and Pancreatic Surgery, “F. Miulli” General Hospital, Acquaviva delle Fonti, 70021 Bari, Italy
Interests: HPB surgery; minimally invasive and robotic surgery

E-Mail Website
Guest Editor
1. Department of Medicine and Surgery, LUM University, Casamassima, 70010 Bari, Italy
2. Unit of Hepato-Biliary and Pancreatic Surgery, “F. Miulli” General Hospital, Acquaviva delle Fonti, 70021 Bari, Italy
Interests: gastroiontestinal cancers; robotic surgery; surgical oncology
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Special Issue Information

Dear Colleagues,

Pancreatic masses represent a clinically significant concern due to their rising global incidence, with pancreatic cancer now ranking among the top causes of cancer-related deaths worldwide.

Pancreatic masses represent a heterogeneous spectrum of neoplasms, with the most common being pancreatic ductal adenocarcinoma, neuroendocrine tumors, and IPMNs. Timely and accurate differentiation among these entities is essential in devising effective therapeutic strategies. Recent advancements in diagnostic modalities, surgical techniques, and perioperative care have significantly influenced the management of pancreatic tumors.

Pancreatic neoplasms can significantly impact patient outcomes based on their nature, origin, and behavior. Some of these tumors may benefit from upfront surgery, while others may need medical therapy alone or prior to surgery.

Pancreatic surgery can be performed using open techniques or minimally invasive approaches, such as laparoscopic or robotic-assisted surgery, depending on the specific case and the surgeon’s experience.

This Special Issue will focus on the surgical and medical management of patients with pancreatic tumors, addressing critical aspects such as neoadjuvant therapy, adjuvant therapy, surgical techniques, short- and long-term outcomes, survival rates, and prognostic factors in recurrence.

Additionally, this Special Issue will explore the factors influencing outcomes, short- and long-term survival, and recurrence rates.

By addressing these multifaceted topics, this Special Issue will provide a comprehensive overview of the current state of the management of pancreatic tumors, offering insights into improving patient outcomes.

This Special Issue will showcase original research, reviews, and case reports that highlight innovative treatment approaches or novel therapies in the field of pancreatic tumors.

We look forward to receiving your contributions.

Dr. Michele Tedeschi
Dr. Antonella Delvecchio
Dr. Riccardo Memeo
Guest Editors

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Keywords

  • pancreatic tumors
  • pancreatic surgery
  • neoadjuvant therapy
  • adjuvant therapy
  • short- and long-term outcomes
  • pancreatic diseases
  • surgical complication
  • recurrence rate
  • medical management
  • prognostic factors

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Published Papers (1 paper)

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Research

12 pages, 262 KB  
Article
Pancreatico-Jejunostomy Fistula After Pancreaticoduodenectomy: Where Do We Stand? Results from an International Survey
by Silvio Caringi, Michele Tedeschi, Antonella Delvecchio, Annachiara Casella, Valentina Ferraro, Cataldo De Palma, Rosalinda Filippo, Matteo Stasi, Tommaso Maria Manzia and Riccardo Memeo
Curr. Oncol. 2025, 32(12), 657; https://doi.org/10.3390/curroncol32120657 - 24 Nov 2025
Viewed by 167
Abstract
Introduction: Pancreatico-duodenectomy (PD) remains one of the most complex abdominal surgeries, and pancreatico-jejunostomy (PJ) fistula is its most critical postoperative complication. In efforts to reduce the incidence of postoperative pancreatic fistula (POPF), several PJ techniques and adjuncts, including stents, have been recommended. This [...] Read more.
Introduction: Pancreatico-duodenectomy (PD) remains one of the most complex abdominal surgeries, and pancreatico-jejunostomy (PJ) fistula is its most critical postoperative complication. In efforts to reduce the incidence of postoperative pancreatic fistula (POPF), several PJ techniques and adjuncts, including stents, have been recommended. This article presents data from an international survey regarding PJ methods, the use of pancreatic stents, and their correlation with POPF rates from surgical centers worldwide. Methods: A nine-item online questionnaire was sent globally through social networks, individual mailing lists, and the ASHBPS mailing list. Data were analyzed through the Student’s t-test (two-tailed, unequal variance). A p-value < 0.05 was considered to be statistically significant. Results: A total of 122 units of pancreatic surgery from 26 countries distributed across five continents responded to the survey. Most centers performed less than 50 PDs a year, preferred a duct-to-mucosa PJ, and employed a stent routinely. Mean POPF grade B and C incidences were lower in high-volume (15.24% ± 7.29 and 3.95% ± 2.39) and in PJ stent-using centers (16.25% ± 8.7 and 5.37% ± 7.49). Conclusions: Institutional case volume and stent usage are more crucial determinants of POPF incidence than the PJ technique itself. Centralization and standardization of PD procedures are related to reductions in major fistula rates. Full article
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