Radiation Therapy and Targeted Therapies for Pancreatic Cancer
A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Gastrointestinal Oncology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 1196
Editor
Special Issue Information
Dear Colleagues,
Pancreatic cancers are associated with poor survival and although treatment approaches have evolved considerably in the last few years, the prognosis continues to be dismal. Since most patients present with advanced disease, as well as because the biology of these cancers are associated with early metastases, the treatment focus has mainly been on systemic therapies. That said, diagnosis and treatment at an early stage when the disease is localized is associated with a considerable improvement in survival and while systemic treatments continue to be the cornerstone for management of pancreatic cancer, for localized and non-metastatic disease, local treatments including surgery and radiation may play a significant role in disease control and potentially even cure in some patients. Much effort is also going into exploring novel treatment strategies that target pathways or molecular signatures that may be characteristic of pancreatic cancers and can be exploited to give better disease control both by themselves and in combination with other conventional treatment strategies.
Radiation therapy has been a part of the canonical treatment arsenal for pancreatic cancers and has been evaluated as a treatment option both on its own as well as in conjunction with systemic therapy, with reports showing varying outcomes. Interest in radiation as a treatment modality has continued despite occassional conflicting outcomes. Recent efforts have also seen the development of therapeutics that target various signaling and molecular pathways and there appears to be a lot of promise as noted both in the preclinical and early human trials. This Special Issue aims to collate as much evidence as possible that specifically looks at the role of radiation therapy in pancreatic cancers, especially in the era of advanced radiotherapy techniques. Along with radiation, this Special Issue will also aim to bring together evidence on targeted therapies currently being explored or in the process of development for the treatment of these cancers.
I/We look forward to receiving your contributions.
Dr. Aswin Abraham
Guest Editor
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Keywords
- pancreatic cancer
- radiation
- chemo-radiation
- SBRT
- patterns of failure
- radiobiology
- radiation techniques
- cell signaling
- immunotherapy and radiation
- targeted therapies
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