New Perspectives in Real-World Drug Safety and Effectiveness in Cancer Treatment

A special issue of Current Oncology (ISSN 1718-7729).

Deadline for manuscript submissions: 25 February 2025 | Viewed by 1093

Special Issue Editors


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Centro Hospitalar Universitário Cova da Beira, Pharmaceutical Services Alameda Pêro da Covilhã, 6200-251 Covilhã, Portugal
Interests: hospital pharmacy; oncology pharmacy; pharmacotherapy; pharmacovigilance; pharmacology; drug interactions; epidemiology; public health; diabetes mellitus; arterial hypertension; dyslipidemia

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Guest Editor
Pharmaceutical Services, Hospital S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Estrada do Forte do Alto do Duque 1400-005 Lisboa, Portugal
Interests: hospital pharmacy; oncology pharmacy; geriatric oncology; pharmacotherapy; pharmacovigilance; pharmacology; drug interactions; epidemiology; public health

E-Mail Website
Guest Editor
Pharmaceutical Services, Hospital S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental, Estrada do Forte do Alto do Duque, 1400-005 Lisboa, Portugal
Interests: hospital pharmacy; oncology pharmacy; geriatric oncology; pharmacotherapy; pharmacovigilance; pharmacology; drug interactions; epidemiology; public health

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Guest Editor
School of Health Sciences, Polytechnic Institute of Guarda, Avenida Rainha D. Amélia, S/N, 6300-749 Guarda, Portugal
Interests: pharmacotherapy; pharmacovigilance; pharmacology; drug interactions; epidemiology; public health; geriatric pharmacotherapy; clinical pharmacy
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Special Issue Information

Dear Colleagues,

We are delighted to announce that the Special Issue entitled “New Perspectives in Real-World Drug Safety and Effectiveness in Cancer Treatment” is now open to receiving proposals.

Real-world data are being increasingly used to evaluate the true effectiveness and safety of innovative antineoplastic therapies such as antibody drugs and tumor-targeted therapy. This is particularly useful for assessing clinical outcomes and drug toxicity profiles in patient populations that are often excluded from randomized clinical trials, such as older patients, or patients with comorbidities, poor performance status or pre-existing autoimmune diseases in the case of immunotherapy trials.

Furthermore, antineoplastic treatments can represent a challenge in daily clinical practice, especially in critical and frail subpopulations such as the elderly, polymedicated patients or patients with complex socio-health conditions such as those caused by the recent COVID-19 pandemic.

Some antineoplastic drugs (e.g., palbociclib for male breast cancer and pembrolizumab for tumors with microsatellite instability) have received Food and Drug Administration (FDA) approvals partially based on real-life data. Therefore, real-world evidence extracted from electronic health records, registers and patient-generated sources promises to provide clinically useful information with reduced time, cost and human effort.

This Special Issue is dedicated to reviews and original articles addressing the issues surrounding the safety and effectiveness of newly introduced cancer drugs/antineoplastic protocols, including drug safety evaluations in real-world settings, clinical consequences on patients' health/cancer treatment and drug adherence.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Real-world studies on cancer treatment;
  • Real-world pharmacovigilance studies on cancer treatment;
  • Real-world effectiveness studies on cancer treatment;
  • Real-world outcome studies on cancer treatment;
  • Real-world studies on cancer treatment with targeted therapies;
  • Real-world studies on cancer treatment with immunotherapy;
  • Real-world drug adherence studies on cancer treatment;
  • Real-world studies on elderly patients’ cancer treatment;
  • Real-world studies on cancer treatment in polymedicated patients;
  • Real world studies on cancer treatment in patients with comorbidities.

We look forward to receiving your contributions.

Prof. Dr. Manuel Morgado
Dr. Patrícia Cavaco
Prof. Dr. Fátima Falcão
Prof. Dr. Fátima Roque
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Oncology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • real-world evidence
  • drug safety
  • pharmacovigilance
  • effectiveness
  • targeted therapies
  • immunotherapy
  • oncology
  • geriatric oncology
  • drug adherence

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Published Papers (1 paper)

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Research

11 pages, 1080 KiB  
Article
Real-World Outcomes of Incurable Cancer Patients Treated with Unlisted Anticancer Treatments in an Academic Center in Quebec, Canada
by Adam Miller, Francois Panet, Victoria Korsos, Wilson H. Miller, Jr. and Gerald Batist
Curr. Oncol. 2024, 31(10), 5908-5918; https://doi.org/10.3390/curroncol31100440 - 1 Oct 2024
Viewed by 509
Abstract
Medical oncology is a rapidly evolving field, with new medications being discovered yearly, contributing to increased survival rates. However, accessing drugs in a timely manner can be challenging. In Quebec, Canada, a physician can prescribe an unlisted anticancer treatment through a regulated pathway [...] Read more.
Medical oncology is a rapidly evolving field, with new medications being discovered yearly, contributing to increased survival rates. However, accessing drugs in a timely manner can be challenging. In Quebec, Canada, a physician can prescribe an unlisted anticancer treatment through a regulated pathway under exceptional circumstances. We conducted a quality improvement study describing the outcomes of incurable cancer patients receiving unlisted anticancer therapy at the Jewish General Hospital between 2018 and 2019. Though our study did not include a comparator arm, unlisted anticancer therapies were associated with interesting median progression-free survival (11 months) and overall survival (25 months). Moreover, a large proportion of treatments, 44%, were subsequently reimbursed in the province of Quebec. Given the delay in anticancer drug reimbursement, this pathway is essential for timely access to oncology drugs. Such ‘special access’ programs will likely become increasingly important as precision medicine becomes the standard of practice. Full article
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