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Advances in Graphene Based Composite for Bio-Applications
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Advances in Graphene Based Composite for Bio-Applications

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: closed (16 April 2022) | Viewed by 16728

Special Issue Editor

Prof. Dr. Mariana Ionita

E-Mail Website
Guest Editor
Faculty of Medical Engineering, Advanced Polymer Materials Group, eBio-Hub Research Centre, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania
Interests: materials science; bioengineering; nanotechnology; tissue regeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am very pleased to invite you to submit your work to the Special Issue on Advances in Graphene based Composite for Bio-Applications. Graphene-based composites have significantly influenced the landscape of biomaterials by providing much-improved effectiveness and economically feasible alternatives for the current treatment options in several areas of biomedical applications. This Special Issue of Coatings focuses on the methods that have been developed and applied to produce hierarchically exquisite graphene structures, and also covers the computational, physical, biological, and chemical sciences that have been utilized to reinforce the design and characterization of graphene-based biomaterials.

The scope of Advances in Graphene based Composites for Bio-Applications includes, but is not limited to:

  • Graphene-based biomaterials development;
  • Graphene novel architectures and concepts;
  • Multifunctional graphene based composites;
  • Processing of graphene materials to achieve specific functionality;
  • Modification of graphene composites with improved performance;
  • Graphene and graphene derivatives mechanical characterization;
  • Graphene composites’ surface, structure, and biocompatibility characterization;
  • Computer-aided design and characterization of graphene/graphene based materials;
  • Graphene materials for implantable devices, drug delivery systems, bionanotechnology, and tissue engineering.

Dr. Mariana Ionita
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (5 papers)

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Research

16 pages, 4432 KiB  
Article
Junction-Producing Algorithm Connecting Carbon Nanotube to Carbon Nanocone to Obtain Funnel-Like Nanostructure: Nanochimney Generator
by Sorin Muraru
Coatings 2020, 10(12), 1267; https://doi.org/10.3390/coatings10121267 - 21 Dec 2020
Cited by 1 | Viewed by 2522
Abstract
This study aims to provide a computational algorithm which contributes to the understanding and implementation of carbon nanochimneys. The structure resembles a tube ending with an inverted funnel, with a connection region that uses non-hexagonal rings as defects in order to match the [...] Read more.
This study aims to provide a computational algorithm which contributes to the understanding and implementation of carbon nanochimneys. The structure resembles a tube ending with an inverted funnel, with a connection region that uses non-hexagonal rings as defects in order to match the boundaries of the two linked nanostructures. They are important for applications such as thermal transport, gas storage, or separation. The algorithm is written in Python 3.7 and provides a .pdb file with the coordinates of all the atoms included in the system. The parameters that can be specified are the carbon nanotube dimensions, for either armchair or zigzag conformations, five levels of disclination for the carbon nanocone along with the base diameter of the latter. Full article
(This article belongs to the Special Issue Advances in Graphene Based Composite for Bio-Applications)
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13 pages, 1992 KiB  
Article
Oligonucleotide Detection and Optical Measurement with Graphene Oxide in the Presence of Bovine Serum Albumin Enabled by Use of Surfactants and Salts
by Florentin R. Nitu, Jorge S. Burns and Mariana Ionită
Coatings 2020, 10(4), 420; https://doi.org/10.3390/coatings10040420 - 23 Apr 2020
Cited by 9 | Viewed by 4796
Abstract
As graphene oxide-based oligonucleotide biosensors improve, there is a growing need to explore their ability to retain high sensitivity for low target concentrations in the context of biological fluids. Therefore, we innovatively combined assay milieu factors that could influence the key performance parameters [...] Read more.
As graphene oxide-based oligonucleotide biosensors improve, there is a growing need to explore their ability to retain high sensitivity for low target concentrations in the context of biological fluids. Therefore, we innovatively combined assay milieu factors that could influence the key performance parameters of DNA hybridization and graphene oxide (GO) colloid dispersion, verifying their suitability to enhance oligonucleotide–GO interactions and biosensor performance. As a model system, we tested single-strand (ss) DNA detection in a complex solution containing bovine serum albumin (BSA) and salts with surfactants. A fluorescein conjugated 30-mer oligonucleotide ssDNA probe was combined with its complementary cDNA target, together with solute dispersed GO and either non-ionic (Triton X-100 and Tween-20) or anionic sodium dodecyl sulfate (SDS) surfactants. In this context, we compared the effect of divalent Mg2+ or monovalent Na+ salts on GO binding for the quench-based detection of specific target–probe DNA hybridization. GO biosensor strategies for quench-based DNA detection include a “turn on” enhancement of fluorescence upon target–probe interaction versus a “turn off” decreased fluorescence for the GO-bound probe. We found that the sensitive and specific detection of low concentrations of oligonucleotide target was best achieved using a strategy that involved target–probe DNA hybridization in the solution with a subsequent modified “turn-off” GO capture and the quenching of the unhybridized probe. Using carefully formulated assay procedures that prevented GO aggregation, the preferential binding and quenching of the unhybridized probe were both achieved using 0.1% BSA, 0.065% SDS and 6 mM NaCl. This resulted in the sensitive measurement of the specific target–probe complexes remaining in the solution. The fluorescein-conjugated single stranded probe (FAM–ssDNA) exhibited linearity to cDNA hybridization with concentrations in the range of 1–8 nM, with a limit of detection equivalent to 0.1 pmoles of target in 100 µL of assay mix. We highlight a general approach that may be adopted for oligonucleotide target detection within complex solutions. Full article
(This article belongs to the Special Issue Advances in Graphene Based Composite for Bio-Applications)
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19 pages, 7972 KiB  
Article
Molecular Dynamics Simulations of DNA Adsorption on Graphene Oxide and Reduced Graphene Oxide-PEG-NH2 in the Presence of Mg2+ and Cl− ions
by Sebastian Muraru, Cosmin Gabriel G. Samoila, Emil I. Slusanschi, Jorge S. Burns and Mariana Ionita
Coatings 2020, 10(3), 289; https://doi.org/10.3390/coatings10030289 - 20 Mar 2020
Cited by 17 | Viewed by 6283
Abstract
Graphene and its functionalised derivatives are transforming the development of biosensors that are capable of detecting nucleic acid hybridization. Using a Molecular Dynamics (MD) approach, we explored single-stranded or double-stranded deoxyribose nucleic acid (ssDNA or dsDNA) adsorption on two graphenic species: graphene oxide [...] Read more.
Graphene and its functionalised derivatives are transforming the development of biosensors that are capable of detecting nucleic acid hybridization. Using a Molecular Dynamics (MD) approach, we explored single-stranded or double-stranded deoxyribose nucleic acid (ssDNA or dsDNA) adsorption on two graphenic species: graphene oxide (GO) and reduced graphene oxide functionalized with aminated polyethylene glycol (rGO-PEG-NH2). Innovatively, we included chloride (Cl−) and magnesium (Mg2+) ions that influenced both the ssDNA and dsDNA adsorption on GO and rGO-PEG-NH2 surfaces. Unlike Cl−, divalent Mg2+ ions formed bridges between the GO surface and DNA molecules, promoting adsorption through electrostatic interactions. For rGO-PEG-NH2, the Mg2+ ions were repulsed from the graphenic surface. The subsequent ssDNA adsorption, mainly influenced by electrostatic forces and hydrogen bonds, could be supported by π–π stacking interactions that were absent in the case of dsDNA. We provide a novel insight for guiding biosensor development. Full article
(This article belongs to the Special Issue Advances in Graphene Based Composite for Bio-Applications)
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15 pages, 4383 KiB  
Article
Graphene Oxide Reinforcing Genipin Crosslinked Chitosan-Gelatin Blend Films
by George Mihail Vlasceanu, Livia Elena Crica, Andreea Madalina Pandele and Mariana Ionita
Coatings 2020, 10(2), 189; https://doi.org/10.3390/coatings10020189 - 23 Feb 2020
Cited by 32 | Viewed by 5093
Abstract
This study was targeted towards the synthesis and characterization of new chitosan–gelatin biocomposite films reinforced with graphene oxide and crosslinked with genipin. The composites’ mode of structuration was characterized by Fourier Transform Infrared spectroscopy and X-ray diffraction, while morphology and topography were investigated [...] Read more.
This study was targeted towards the synthesis and characterization of new chitosan–gelatin biocomposite films reinforced with graphene oxide and crosslinked with genipin. The composites’ mode of structuration was characterized by Fourier Transform Infrared spectroscopy and X-ray diffraction, while morphology and topography were investigated by scanning electron microscopy, nano-computer tomography and profilometry. Eventually, thermal stability was evaluated through thermogravimetrical analysis, mechanical properties assessment was carried out to detect potential improvements as a result of graphene oxide (GO) addition and in vitro enzyme degradation was performed to discern the most promising formulations for the maturation of the study towards in vivo assays. In accordance with similar works, results indicated the possibility of using GO as an agent for adjusting films’ roughness, chemical stability and polymer structuration. The enzymatic stability of chitosan–gelatin (CHT-GEL) films was also improved by genipin (GEN) crosslinking and GO supplementation, with the best results being obtained for CHT-GEL-GEN and CHT-GEL-GEN-GO3 (crosslinked formulation with 3 wt.% GO). Yet, contrary to previous reports, no great enhancement of CHT-GEN-GEL-GO thermal performances was obtained by the incorporation of GO. Full article
(This article belongs to the Special Issue Advances in Graphene Based Composite for Bio-Applications)
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12 pages, 2518 KiB  
Article
Mechanical and Thermal Properties of Waterborne Polyurethane Coating Modified through One-Step Cellulose Nanocrystals/Graphene Materials Sols Method
by Feng Yang, Yan Wu, Shuqin Zhang, Haiming Zhang, Suilang Zhao, Jilei Zhang and Benhua Fei
Coatings 2020, 10(1), 40; https://doi.org/10.3390/coatings10010040 - 2 Jan 2020
Cited by 31 | Viewed by 4690
Abstract
Developing multifunctional coatings with excellent mechanical and thermal properties is highly desirable for wood-based composite application. The recent development of waterborne coatings for wood products suggests that a promising thermosetting material needs to also have properties like low volatile organic contents (VOCs), hardness, [...] Read more.
Developing multifunctional coatings with excellent mechanical and thermal properties is highly desirable for wood-based composite application. The recent development of waterborne coatings for wood products suggests that a promising thermosetting material needs to also have properties like low volatile organic contents (VOCs), hardness, and fast curing. The cellulose nanocrystals/graphene materials (CNC/GM) sols were prepared through the one-step method as the thermally conductive and reinforced modifier for preparing waterborne polyurethane (WPU) coatings. The influence of this modifier on the thermal and mechanical properties such as thermal conductivity, abrasion resistance, and adhesion of WPU coatings was investigated. The results indicated that adding CNC/GM sols increased the hardness, abrasion resistance, and thermal conductivity of the WPU coatings, and meanwhile maintained the coating adhesion at the highest grade (level 1). The highest abrasion resistance value of 0.023 g/100 r was obtained for the modified WPU coating when the addition of GM was 3%. Full article
(This article belongs to the Special Issue Advances in Graphene Based Composite for Bio-Applications)
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