Post-Translational Modification Networks in Disease and Therapy: From Chromatin Regulation to Protein Stability
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 28
Special Issue Editor
Interests: SMYD proteins; structure and function relationships; data science
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Post-translational modifications (PTMs) play a crucial role in regulating protein function, stability, and interactions, thereby influencing key biological processes in health and disease. These modifications, including phosphorylation, methylation, ubiquitination, acetylation, and sumoylation, govern chromatin dynamics, transcriptional regulation, and cellular signaling pathways. Dysregulation of PTM networks is frequently implicated in cancer, neurodegenerative disorders, and other pathological conditions, highlighting their potential as therapeutic targets. This Special Issue explores the diverse roles of PTMs in disease mechanisms and therapeutic strategies, with a particular focus on their impact on chromatin organization and protein stability. We welcome studies employing structural biology, computational modeling, biochemical assays, and omics-based approaches to dissect the regulatory networks of PTMs. Additionally, contributions that elucidate how PTMs modulate protein–protein interactions, cellular signaling, and drug response are encouraged. By bringing together cutting-edge research in this field, we aim to provide a comprehensive understanding of PTM-mediated regulatory mechanisms and their translational potential in disease treatment. This Special Issue will serve as a valuable resource for researchers seeking to uncover novel PTM-based therapeutic strategies.
Dr. Zhe Yang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- post-translational modifications
- protein stability
- chromatin regulation
- phosphorylation
- ubiquitination
- methylation
- acetylation
- sumoylation
- disease mechanisms
- targeted therapy
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
