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Effects of Environmental Factors on Cardiovascular Disease: From Molecular Effects to Possible Future Clinic Application

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 782

Special Issue Editor


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Guest Editor
Department of Clinical Molecular Biology, Medical University of Bialystok, 15-269 Bialystok, Poland
Interests: environmental factors; health status; healthy eating; healthy lifestyle; health monitoring; physical activity; alcohol consumption reduction; tobacco cessation; stress management

Special Issue Information

Dear Colleagues,

This Special Issue focus on cardiovascular diseases, especially on identifying health risks and understanding the determinants of potential abnormalities. We would like to understand the causes and effects of cardiovascular diseases, especially hypertension, already occurring at the molecular level, while also wishing to encourage future researchers to understand and explore molecular analysis in depth in the aspect of public health.

Cardiovascular diseases result from complex dysfunctions of various pathways and pathomechanisms, and are the most common cause of mortality worldwide. Conducting continuous observations of the population's diet and assessing occupational exposures and environmental influences are key to identifying the health risks and understanding the determinants of potential abnormalities in the context of the development of diseases.

Deciphering at least some of the mechanisms underlying cardiovascular disease would open up new opportunities for prevention, promotion of healthy lifestyles and/or proper diagnosis of cardiovascular pathology.

In this Special Issue (including both known and yet undefined molecular aspects), I invite researchers to present their findings and new information, including pathomechanisms, biomarkers, and molecular insights, from public health perspectives for the entire spectrum of cardiovascular disease to new prevention concepts resulting from unhealthy lifestyles. New information, as well as interactions between dietary habits, lifestyle, and the cardiovascular system, are welcome.

I look forward to receiving the valuable contributions from researchers and academicians all around the world.

Dr. Angelika Edyta Charkiewicz
Guest Editor

Manuscript Submission Information

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Keywords

  • environmental factors
  • cardiovascular diseases
  • disease and chronic risk
  • health status
  • healthy eating
  • healthy lifestyle
  • physical activity
  • alcohol consumption reduction
  • tobacco cessation
  • public health
  • population health
  • psychosocial factors
  • dietary recommendations
  • nutrient intake
  • health outcomes

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Published Papers (2 papers)

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Review

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37 pages, 2032 KiB  
Review
Galectin-3 in Cardiovascular Health: A Narrative Review Based on Life’s Essential 8 and Life’s Simple 7 Frameworks
by Adrian Martuszewski, Patrycja Paluszkiewicz, Rafał Poręba and Paweł Gać
Curr. Issues Mol. Biol. 2025, 47(5), 332; https://doi.org/10.3390/cimb47050332 - 6 May 2025
Abstract
Gal-3, also known as galectin-3, a lectin that binds β-galactosides, has gained attention as a novel biomarker and pathophysiological mediator in cardiovascular disease, where it contributes to inflammation, fibrosis, metabolic dysregulation and cardiac remodeling. This narrative review, developed following SANRA (Scale for the [...] Read more.
Gal-3, also known as galectin-3, a lectin that binds β-galactosides, has gained attention as a novel biomarker and pathophysiological mediator in cardiovascular disease, where it contributes to inflammation, fibrosis, metabolic dysregulation and cardiac remodeling. This narrative review, developed following SANRA (Scale for the Assessment of Narrative Review Articles) guidelines, aims to integrate current clinical and experimental findings on gal-3 into the American Heart Association Life’s Simple 7 (LS7) and Life’s Essential 8 (LE8). By thematically organizing our review across modifiable domains of cardiovascular health, including glucose regulation, lipid metabolism, physical activity, blood pressure, diet, sleep, tobacco use, and body weight (BMI, body mass index), we highlight the role of gal-3 in linking environmental, behavioral and molecular risk factors to cardiometabolic outcomes. Particular attention is given to the oxidative stress, inflammatory–fibrotic axis, and immune activation as mechanistic pathways underlying gal-3-associated cardiovascular damage. We also discuss its relevance to public health and prevention, considering gal-3’s potential for early risk stratification, monitoring lifestyle interventions and personalized prevention strategies. This review bridges molecular mechanisms with clinical and public health relevance, particularly in the context of environmental and lifestyle-related cardiovascular risk. Full article
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17 pages, 3001 KiB  
Perspective
A Proposal for Research Involving New Biomarkers of Hypertension, Lifestyle, and Environmental Exposure
by Angelika Edyta Charkiewicz
Curr. Issues Mol. Biol. 2025, 47(3), 206; https://doi.org/10.3390/cimb47030206 - 18 Mar 2025
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Abstract
The constant monitoring of the population’s diet and assessment of occupational exposure and environmental impacts are the key to determining health risks and understanding the factors contributing to potential abnormalities in developing lifestyle diseases. Extensive long-term lifestyle monitoring studies can provide data on [...] Read more.
The constant monitoring of the population’s diet and assessment of occupational exposure and environmental impacts are the key to determining health risks and understanding the factors contributing to potential abnormalities in developing lifestyle diseases. Extensive long-term lifestyle monitoring studies can provide data on population health risks, including the most common cardiovascular diseases like hypertension. This paper presents research recommendations for future researchers and doctors to improve the diagnosis of hypertension and targeted, personalised treatment. The research proposal includes a lifestyle study, a diagnostic panel with new biomarkers, and an environmental exposure assessment of men working in the metallurgical industry. New developments and improved interventions are constantly being sought, including new biomarkers with high diagnostic utility for cardiovascular diseases like hypertension. This should enable early diagnosis, and consequently allow for appropriate and, most importantly, personalised therapy, and prevent an increase in CVD deaths. Only the effective diagnosis, treatment, and monitoring of hypertension can reduce the risk of developing diseases associated with hypertension. I propose that several new parameters (NO, cfDNA, MPO, PCSK9, MyBPC3, microRNA, TAS, Pb, and Cd) with prognostic and/or predictive potential should be included in screening to confirm the need for the extensive testing of middle-aged men by healthcare professionals due to the risk of hypertension. Full article
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