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The Roles of Phytochemicals in Neuroprotective Mechanism

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 1279

Special Issue Editor

Special Issue Information

Dear Colleagues,

Phytochemicals are naturally occurring, and common phytochemicals include curcumin, quercetin, diallyl trisulfide, flavonoids, and epigallocatechin-3-gallate (EGCG). They have been extensively studied and applied in neuroprotection. Their mechanisms of action are complex and varied, but the common denominator is that they can all help protect the nervous system from damage and aging through different pathways. Studying potent drugs with antioxidant or anti-inflammatory activities from natural phytochemicals is becoming an essential strategy for developing neuroprotective agents.

This Special Issue aims to bring together articles on the potential mechanisms of protective effects of phytochemicals and their synergistic effects with drugs. Authors are invited to submit manuscripts as original research and review articles.

Prof. Dr. Jui-Hung Yen
Guest Editor

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Keywords

  • phytochemicals
  • pharmaceuticals
  • biochemistry
  • neuroprotection

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Published Papers (1 paper)

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Research

21 pages, 2799 KiB  
Article
Behavioral and Amygdala Biochemical Damage Induced by Alternating Mild Stress and Ethanol Intoxication in Adolescent Rats: Reversal by Argan Oil Treatment?
by Hicham El Mostafi, Aboubaker Elhessni, Hanane Doumar, Tarik Touil and Abdelhalem Mesfioui
Int. J. Mol. Sci. 2024, 25(19), 10529; https://doi.org/10.3390/ijms251910529 - 30 Sep 2024
Viewed by 948
Abstract
Adolescence is a critical period when the effects of ethanol and stress exposure are particularly pronounced. Argan oil (AO), a natural vegetable oil known for its diverse pharmacological benefits, was investigated for its potential to mitigate addictive-like behaviors and brain damage induced by [...] Read more.
Adolescence is a critical period when the effects of ethanol and stress exposure are particularly pronounced. Argan oil (AO), a natural vegetable oil known for its diverse pharmacological benefits, was investigated for its potential to mitigate addictive-like behaviors and brain damage induced by adolescent intermittent ethanol intoxication (IEI) and unpredictable mild stress (UMS). From P30 to P43, IEI rats received a daily ip ethanol (3 g/kg) on a two-day on/two-day off schedule. On alternate days, the rats were submitted to UMS protocol. Next, a two-bottle free access paradigm was performed over 10 weeks to assess intermittent 20% ethanol voluntary consumption. During the same period, the rats were gavaged daily with AO (15 mL/kg). Our results show that IEI/UMS significantly increased voluntary alcohol consumption (from 3.9 g/kg/24 h to 5.8 g/kg/24 h) and exacerbated withdrawal signs and relapse-like drinking in adulthood. Although AO treatment slightly reduced ethanol intake, it notably alleviated withdrawal signs during abstinence and relapse-like drinking in adulthood. AO’s effects were associated with its modulation of the HPA axis (elevated serum corticosterone), restoration of amygdala oxidative balance, BDNF levels, and attenuation of neurodegeneration. These findings suggest that AO’s neuroprotective properties could offer a potential therapeutic avenue for reducing ethanol/stress-induced brain damage and addiction. Further research is needed to explore its mechanisms and therapeutic potential in alcohol use disorders. Full article
(This article belongs to the Special Issue The Roles of Phytochemicals in Neuroprotective Mechanism)
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