Molecular Research on Free Radicals and Oxidative Stress—2nd Edition
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 1404
Special Issue Editor
Interests: oxidative stress; reactive oxygen species (ROS); free radicals; inflammation; microcirculation; blood–brain barrier
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress is a condition characterized by an imbalance between unstable reactive oxygen species (ROS) production and the body's antioxidant defense mechanisms. Free radicals, which include superoxide radicals (O2•−), hydroxyl radicals (•OH), and peroxyl radicals (ROO•), as well as reactive nitrogen species (RNS) such as nitric oxide (•NO) and nitrogen dioxide (•NO2), are highly reactive molecules with unpaired electrons that play a pivotal role in oxidative stress by damaging cellular components, such as lipids, proteins, and DNA.
Various environmental factors, such as radiation exposure, obesity, smoking, pollution, alcohol consumption, dietary habits, and lifestyle, contribute to the generation of free radicals, exacerbating oxidative stress and disrupting the physiological antioxidant defense system. While some free radicals play important roles in physiological processes, such as cell signaling and immune responses, their excessive accumulation can lead to oxidative stress and damage to cellular components, contributing to various diseases and aging processes, including neurodegenerative diseases, cancer, atherosclerosis, diabetes, infertility, and fibrosis.
At the molecular level, the mechanisms driving oxidative-induced cellular dysfunction are complex and include mitochondrial damage, autophagy, mitophagy, endoplasmic reticulum stress, and apoptosis. However, the intricate interactions among these mechanisms, especially in metabolic diseases, are not fully understood.
Folllowing the success of the first edition, for the second edition of this Special Issue, we invite the submission of original research articles and reviews elucidating the role of oxidative stress and unravelling the underlying molecular mechanisms. We hope to advance our understanding of oxidative stress-related pathologies and pave the way for innovative therapeutic strategies.
Dr. Mosharraf Sarker
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxidative stress
- free radicals
- reactive oxygen species (ROS)
- gene regulation
- antioxidants
- mitochondrial dysfunction
- insulin resistance
- inflammation
- autophagy
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