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Unraveling the Molecular Marvels of Heart Repair and Regeneration

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 472

Special Issue Editor


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Guest Editor
Department of Surgery, Molecular Cardiology and Angiogenesis Laboratory, University of Connecticut School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA
Interests: therapeutic angiogenesis; ischemic heart; signal transduction; tissue repair and regeneration; gene expression; apoptosis; diabetic cardiomyopathy; exosome; peripheral artery disease; sepsis

Special Issue Information

Dear Colleagues,

Myocardial infarction, heart failure, and many cardiac-related diseases are increasing in occurrence; therefore, there is a growing demand for effective research approaches for myocardial repair and regeneration. Cardiovascular regenerative therapies are heavily debated when discussing their effectiveness. However, understanding the mechanisms involved in myocardial repair and regeneration is broadly accepted as being essential in moving forward with these studies. Myocardial infarction refers to a loss of functional tissue, leading to ischemic issues (e.g., angina), mechanical dysfunctions (e.g., heart failure, cardiac rupture), and arrhythmic concerns. Long-term cardiac damage or failure can be heavily reduced by preserving survival proteins and the functionality of cells. Another imperative factor in terms of the survival and protection of cardiac tissue after an injury is the survival of cardiomyocytes. Several factors can promote this preservation, including autophagy, a lysosome-dependant mechanism that allows the cell to remove any dysfunctional or damaged proteins, and anti-apoptotic signals that counteract cell death, ultimately enhancing the efficiency of myocardial repair and regeneration, which starts with the complete understanding and application of the mechanisms and strategies that take advantage of the biological pathways involved in the cardiovascular system. The recognition of these mechanisms aims to motivate the fundamental studies required to move forward with various therapies in order to further the regeneration and repair of myocardial tissue.

Prof. Dr. Nilanjana Maulik
Guest Editor

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Keywords

  • cardiac repair
  • angiogenesis
  • heart failure
  • ischemia
  • reperfusion
  • reactive oxygen
  • cell therapy
  • exosome therapy
  • gene therapy
  • apoptosis
  • ischemic preconditioning
  • gene editing

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Published Papers (1 paper)

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Review

16 pages, 452 KiB  
Review
Selected Medicines That Can Cause Cardiac Arrest with Asystole
by Kamila Czarnecka, Mateusz Jędrzejec, Aleksandra Kukiełczyńska, Jacek Owczarek, Łukasz Olejnik and Paweł Szymański
Curr. Issues Mol. Biol. 2025, 47(5), 299; https://doi.org/10.3390/cimb47050299 - 24 Apr 2025
Viewed by 211
Abstract
One of the most serious consequences of cardiac arrest is asystole. It can occur in patients suffering from cardio-vascular diseases or during surgery following the use of certain drugs. The aim of this study was to identify the relationship between such use and [...] Read more.
One of the most serious consequences of cardiac arrest is asystole. It can occur in patients suffering from cardio-vascular diseases or during surgery following the use of certain drugs. The aim of this study was to identify the relationship between such use and the occurrence of cardiac arrest or asystole based on a review of literature identified in Science Direct, Web of Science and PubMed. Our findings confirm that a relationship exists between the use of certain drugs and the occurrence of asystole. Most drugs which induce asystole are used in cardiovascular disease, particularly beta-blockers, calcium L-channel blockers and potassium channel blockers. Medicine which can lead to asystole are drugs used, among others, for sedation during surgeries and intended for anesthesia; however, the relationship with asystole is not as clear as for the cardio-vascular drugs. Most patients who experience asystole during surgery after administration of the same drugs had other very serious health problems. Our findings are intended to support medical professionals in anticipating the possibility of asystole after drug administration. Full article
(This article belongs to the Special Issue Unraveling the Molecular Marvels of Heart Repair and Regeneration)
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