Unraveling the Molecular Marvels of Heart Repair and Regeneration
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 655
Special Issue Editor
Interests: therapeutic angiogenesis; ischemic heart; signal transduction; tissue repair and regeneration; gene expression; apoptosis; diabetic cardiomyopathy; exosome; peripheral artery disease; sepsis
Special Issue Information
Dear Colleagues,
Myocardial infarction, heart failure, and many cardiac-related diseases are increasing in occurrence; therefore, there is a growing demand for effective research approaches for myocardial repair and regeneration. Cardiovascular regenerative therapies are heavily debated when discussing their effectiveness. However, understanding the mechanisms involved in myocardial repair and regeneration is broadly accepted as being essential in moving forward with these studies. Myocardial infarction refers to a loss of functional tissue, leading to ischemic issues (e.g., angina), mechanical dysfunctions (e.g., heart failure, cardiac rupture), and arrhythmic concerns. Long-term cardiac damage or failure can be heavily reduced by preserving survival proteins and the functionality of cells. Another imperative factor in terms of the survival and protection of cardiac tissue after an injury is the survival of cardiomyocytes. Several factors can promote this preservation, including autophagy, a lysosome-dependant mechanism that allows the cell to remove any dysfunctional or damaged proteins, and anti-apoptotic signals that counteract cell death, ultimately enhancing the efficiency of myocardial repair and regeneration, which starts with the complete understanding and application of the mechanisms and strategies that take advantage of the biological pathways involved in the cardiovascular system. The recognition of these mechanisms aims to motivate the fundamental studies required to move forward with various therapies in order to further the regeneration and repair of myocardial tissue.
Prof. Dr. Nilanjana Maulik
Guest Editor
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Keywords
- cardiac repair
- angiogenesis
- heart failure
- ischemia
- reperfusion
- reactive oxygen
- cell therapy
- exosome therapy
- gene therapy
- apoptosis
- ischemic preconditioning
- gene editing
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